Comparison of the back-to-back reproducibility of the Siena/FSL whole brain atrophy measurement at 3T and 1.5T using the ADNI MPRAGE MRIs

Keith Cover; Ronald van Schijndel; Bob van Dijk; Alberto Redolfi; Dirk Knol; Giovanni Battista Frisoni; Frederik Barkhof; Hugo Vrenken

doi:10.1016/j.jalz.2011.05.158

Comparison of the back-to-back reproducibility of the Siena/FSL whole brain atrophy measurement at 3T and 1.5T using the ADNI MPRAGE MRIs

Keith Cover
, Ronald van Schijndel
, Bob van Dijk
, Alberto Redolfi
, Dirk Knol
, Giovanni Battista Frisoni
, Frederik Barkhof
, Hugo Vrenken

Research output: Contribution to conference › Abstract › Academic

Abstract

Background: There is substantial evidence to demonstrate that whole brain atrophy measurements perform significantly differently at 3T than1.5T [1]. MRI based measurement of atrophy, such as whole brain and hippocampus, are being used as biomarkers in diseases such as Alzheimer's disease (AD) and multiple sclerosis (MS). Thus a comparison of their respective performances at 3T and 1.5T for planning clinical trials is needed. The aim of this study is to compare the reproducibility of the Siena/FSL whole brain atrophy measurement algorithm at the two field strengths, using back-toback( BTB) MPRAGE MRI scans from the ADNI study acquired at both 3T and 1.5T for each subject. Methods: We selected ADNI subjects who had BTB

Original language	English
Pages	S65-S66
DOIs	https://doi.org/10.1016/j.jalz.2011.05.158
Publication status	Published - 2 Aug 2011

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10.1016/j.jalz.2011.05.158

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title = "Comparison of the back-to-back reproducibility of the Siena/FSL whole brain atrophy measurement at 3T and 1.5T using the ADNI MPRAGE MRIs",

abstract = "Background: There is substantial evidence to demonstrate that whole brain atrophy measurements perform significantly differently at 3T than1.5T [1]. MRI based measurement of atrophy, such as whole brain and hippocampus, are being used as biomarkers in diseases such as Alzheimer's disease (AD) and multiple sclerosis (MS). Thus a comparison of their respective performances at 3T and 1.5T for planning clinical trials is needed. The aim of this study is to compare the reproducibility of the Siena/FSL whole brain atrophy measurement algorithm at the two field strengths, using back-toback( BTB) MPRAGE MRI scans from the ADNI study acquired at both 3T and 1.5T for each subject. Methods: We selected ADNI subjects who had BTB",

author = "Keith Cover and \{van Schijndel\}, Ronald and \{van Dijk\}, Bob and Alberto Redolfi and Dirk Knol and Frisoni, \{Giovanni Battista\} and Frederik Barkhof and Hugo Vrenken",

year = "2011",

month = aug,

day = "2",

doi = "10.1016/j.jalz.2011.05.158",

language = "English",

pages = "S65--S66",

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T1 - Comparison of the back-to-back reproducibility of the Siena/FSL whole brain atrophy measurement at 3T and 1.5T using the ADNI MPRAGE MRIs

AU - Cover, Keith

AU - van Schijndel, Ronald

AU - van Dijk, Bob

AU - Redolfi, Alberto

AU - Knol, Dirk

AU - Frisoni, Giovanni Battista

AU - Barkhof, Frederik

AU - Vrenken, Hugo

PY - 2011/8/2

Y1 - 2011/8/2

N2 - Background: There is substantial evidence to demonstrate that whole brain atrophy measurements perform significantly differently at 3T than1.5T [1]. MRI based measurement of atrophy, such as whole brain and hippocampus, are being used as biomarkers in diseases such as Alzheimer's disease (AD) and multiple sclerosis (MS). Thus a comparison of their respective performances at 3T and 1.5T for planning clinical trials is needed. The aim of this study is to compare the reproducibility of the Siena/FSL whole brain atrophy measurement algorithm at the two field strengths, using back-toback( BTB) MPRAGE MRI scans from the ADNI study acquired at both 3T and 1.5T for each subject. Methods: We selected ADNI subjects who had BTB

AB - Background: There is substantial evidence to demonstrate that whole brain atrophy measurements perform significantly differently at 3T than1.5T [1]. MRI based measurement of atrophy, such as whole brain and hippocampus, are being used as biomarkers in diseases such as Alzheimer's disease (AD) and multiple sclerosis (MS). Thus a comparison of their respective performances at 3T and 1.5T for planning clinical trials is needed. The aim of this study is to compare the reproducibility of the Siena/FSL whole brain atrophy measurement algorithm at the two field strengths, using back-toback( BTB) MPRAGE MRI scans from the ADNI study acquired at both 3T and 1.5T for each subject. Methods: We selected ADNI subjects who had BTB

UR - http://www.mendeley.com/research/comparison-backtoback-reproducibility-sienafsl-whole-brain-atrophy-measurement-3t-15t-using-adni-mpr

U2 - 10.1016/j.jalz.2011.05.158

DO - 10.1016/j.jalz.2011.05.158

M3 - Abstract

SP - S65-S66

ER -

Comparison of the back-to-back reproducibility of the Siena/FSL whole brain atrophy measurement at 3T and 1.5T using the ADNI MPRAGE MRIs

Abstract

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