TY - JOUR
T1 - Comparison between the difficulty of laparoscopic limited liver resections of tumors located in segment 7 versus segment 8
T2 - An international multicenter propensity-score matched study
AU - Efanov, Mikhail
AU - Salimgereeva, Diana
AU - Alikhanov, Ruslan
AU - Wu, Andrew G. R.
AU - Geller, David
AU - Cipriani, Federica
AU - Aghayan, Davit L.
AU - Fretland, Asmund Avdem
AU - Sijberden, Jasper
AU - Belli, Andrea
AU - Marino, Marco V.
AU - Mazzaferro, Vincenzo
AU - Chiow, Adrian K. H.
AU - Sucandy, Iswanto
AU - Ivanecz, Arpad
AU - Choi, Sung Hoon
AU - Lee, Jae Hoon
AU - Prieto, Mikel
AU - Vivarelli, Marco
AU - Giuliante, Felice
AU - Ruzzenente, Andrea
AU - Yong, Chee-Chien
AU - Fondevila, Constantino
AU - Rotellar, Fernando
AU - Choi, Gi-Hong
AU - Robless Campos, Ricardo
AU - Wang, Xiaoying
AU - Sutcliffe, Robert P.
AU - Pratschke, Johann
AU - Lai, Eric
AU - Chong, Charing C.
AU - D'Hondt, Mathieu
AU - Monden, Kazuteru
AU - Lopez-Ben, Santiago
AU - Herman, Paulo
AU - di Benedetto, Fabrizio
AU - Kingham, T. Peter
AU - Liu, Rong
AU - Long, Tran Cong duy
AU - Ferrero, Alessandro
AU - Levi Sandri, Giovanni Battista
AU - Cherqui, Daniel
AU - Scatton, Olivier
AU - Wakabayashi, Go
AU - Troisi, Roberto I.
AU - Cheung, Tan-To
AU - Sugioka, Atsushi
AU - Han, Ho-Seong
AU - Abu Hilal, Mohammad
AU - Soubrane, Olivier
AU - Fuks, David
AU - Aldrighetti, Luca
AU - Edwin, Bjorn
AU - Goh, Brian K. P.
AU - International Robotic and Laparoscopic Liver Resection Study Group Investigators
AU - Chan, Chung-Yip
AU - Syn, Nicholas
AU - D’Silva, Mizelle
AU - Lee, Boram
AU - Lim, Chetana
AU - Nghia, Phan Phuoc
AU - Gastaca, Mikel
AU - Schotte, Henri
AU - de Meyere, Celine
AU - Krenzien, Felix
AU - Schmelzle, Moritz
AU - Lee, Kit-Fai
AU - Lee, Lip Seng
AU - Jang, Jae Young
AU - Kojima, Masayuki
AU - Kato, Yutaro
AU - Ghotbi, Jacob
AU - Kruger, Jaime Arthur Pirola
AU - Coelho, Fabricio Ferreira
AU - Lopez-Lopez, Victor
AU - Valle, Bernardo Dalla
AU - Robert, Margarida Casellas I.
AU - Mishima, Kohei
AU - Montalti, Roberto
AU - Giglio, Mariano
AU - Wang, Hao-Ping
AU - Pascual, Franco
AU - Saleh, Mansour
AU - Kadam, Prashant
AU - Tang, Chung-Ngai
AU - Ardito, Francesco
AU - Vani, Simone
AU - Giustizieri, Ugo
AU - Citterio, Davide
AU - Mocchegiani, Federico
AU - Ettorre, Giuseppe Maria
AU - Colasanti, Marco
AU - Guzmán, Yoelimar
AU - Dogeas, Epameinondas
AU - Magistri, Paolo
AU - Mazzotta, Alessandro
N1 - Funding Information:
This research was partially supported by the US National Cancer Institute MSKCC Core (Grant number: P30 CA008748).
Funding Information:
(i) Dr Goh BK has received travel grants and honorarium from Johnson and Johnson and Transmedic the local distributor for the Da Vinci Robot. (ii) Dr Marino MV is a consultant for CAVA robotics LLC. (iii) Johann Pratschke reports a research grant from Intuitive Surgical Deutschland GmbH and personal fees or non‐financial support from Johnson & Johnson, Medtronic, AFS Medical, Astellas, CHG Meridian, Chiesi, Falk Foundation, La Fource Group, Merck, Neovii, NOGGO, pharma‐consult Peterson, and Promedicis. (iv) Moritz Schmelzle reports personal fees or other support outside of the submitted work from Merck, Bayer, ERBE, Amgen, Johnson & Johnson, Takeda, Olympus, Medtronic, Intuitive. (v) Asmund Fretland reports receiving speaker fees from Bayer. (vi) Fernando Rotellar reports speaker fees and support outside the submitted work from Integra, Medtronic, Olympus, Corza, Sirtex and Johnson & Johnson.
Publisher Copyright:
© 2022 Japanese Society of Hepato-Biliary-Pancreatic Surgery.
PY - 2023/2
Y1 - 2023/2
N2 - Background: Presently, according to different difficulty scoring systems, there is no difference in complexity estimation of laparoscopic liver resection (LLR) of segments 7 and 8. However, there is no published data supporting this assumption. To date, no studies have compared the outcomes of laparoscopic parenchyma-sparing resection of the liver segments 7 and 8. Methods: A post hoc analysis of patients undergoing LLR of segments 7 and 8 in 46 centers between 2004 and 2020 was performed. 1:1 Propensity score matching (PSM) was used to compare isolated LLR of segments 7 and 8. Subset analyses were also performed to compare atypical resections and segmentectomies of 7 and 8. Results: A total of 2411 patients were identified, and 1691 patients met the inclusion criteria. Comparison after PSM between the entire cohort of segment 7 and segment 8 resections revealed inferior results for segment 7 resection in terms of increased blood loss, blood transfusions, and conversions to open surgery. Subset analyses of only atypical resections similarly demonstrated poorer outcomes for segment 7 in terms of increased blood loss, operation time, blood transfusions, and conversions to open surgery. Conversely, a subgroup analysis of segmentectomies after PSM found better outcomes for segment 7 in terms of a shorter operation time and hospital stay. Conclusion: Differences in the outcomes of segments 7 and 8 resections suggest a greater difficulty of laparoscopic atypical resection of segment 7 compared to segment 8, and greater difficulty of segmentectomy 8 compared to segmentectomy 7.
AB - Background: Presently, according to different difficulty scoring systems, there is no difference in complexity estimation of laparoscopic liver resection (LLR) of segments 7 and 8. However, there is no published data supporting this assumption. To date, no studies have compared the outcomes of laparoscopic parenchyma-sparing resection of the liver segments 7 and 8. Methods: A post hoc analysis of patients undergoing LLR of segments 7 and 8 in 46 centers between 2004 and 2020 was performed. 1:1 Propensity score matching (PSM) was used to compare isolated LLR of segments 7 and 8. Subset analyses were also performed to compare atypical resections and segmentectomies of 7 and 8. Results: A total of 2411 patients were identified, and 1691 patients met the inclusion criteria. Comparison after PSM between the entire cohort of segment 7 and segment 8 resections revealed inferior results for segment 7 resection in terms of increased blood loss, blood transfusions, and conversions to open surgery. Subset analyses of only atypical resections similarly demonstrated poorer outcomes for segment 7 in terms of increased blood loss, operation time, blood transfusions, and conversions to open surgery. Conversely, a subgroup analysis of segmentectomies after PSM found better outcomes for segment 7 in terms of a shorter operation time and hospital stay. Conclusion: Differences in the outcomes of segments 7 and 8 resections suggest a greater difficulty of laparoscopic atypical resection of segment 7 compared to segment 8, and greater difficulty of segmentectomy 8 compared to segmentectomy 7.
KW - hepatectomy
KW - laparoscopy
KW - liver resection
KW - posterosuperior segments
KW - risk score
UR - https://www.scopus.com/pages/publications/85134238083
U2 - 10.1002/jhbp.1210
DO - 10.1002/jhbp.1210
M3 - Article
C2 - 35758911
SN - 1868-6974
VL - 30
SP - 177
EP - 191
JO - Journal of hepato-biliary-pancreatic sciences
JF - Journal of hepato-biliary-pancreatic sciences
IS - 2
ER -