TY - JOUR
T1 - Comparable efficacy of low- versus high-dose induction corticosteroid treatment in autoimmune pancreatitis
AU - Buijs, Jorie
AU - van Heerde, Marianne J.
AU - Rauws, Erik A. J.
AU - de Buy Wenniger, Lucas J. Maillette
AU - Hansen, Bettina E.
AU - Biermann, Katharina
AU - Verheij, Joanne
AU - Vleggaar, Frank P.
AU - Brink, Menno A.
AU - Beuers, Ulrich H. W.
AU - Kuipers, Ernst J.
AU - Bruno, Marco J.
AU - van Buuren, Henk R.
PY - 2014/3
Y1 - 2014/3
N2 - The objective of this study was to compare efficacy of high versus low doses of prednisone for induction of remission in autoimmune pancreatitis (AIP). This is a retrospective, multicenter study including patients diagnosed with AIP between May 1992 and August 2011. Clinical, laboratory and imaging findings were assessed before treatment and at 1, 3, and 6 months after starting treatment. A total of 65 patients (57 males; median age, 63 years) were treated with an initial low dose (10-20 mg/d, n = 14), a medium dose (30 mg/d, n = 15), or a high dose (40-60 mg/d, n = 36) of prednisone. There were no significant differences in baseline characteristics between the treatment groups including age, presenting symptoms and laboratory results. During a follow-up period of 6 months, in nearly all patients, symptoms (jaundice, weight loss) resolved completely. After 6 months, treatment response with respect to symptomatic, radiological, and laboratory improvement was comparable for the different dosage groups. Response to therapy was comparable for AIP patients treated with doses of prednisone in the range of 10 to 60 mg/d. A prospective trial should be conducted to confirm efficacy of lower-dose prednisone treatment
AB - The objective of this study was to compare efficacy of high versus low doses of prednisone for induction of remission in autoimmune pancreatitis (AIP). This is a retrospective, multicenter study including patients diagnosed with AIP between May 1992 and August 2011. Clinical, laboratory and imaging findings were assessed before treatment and at 1, 3, and 6 months after starting treatment. A total of 65 patients (57 males; median age, 63 years) were treated with an initial low dose (10-20 mg/d, n = 14), a medium dose (30 mg/d, n = 15), or a high dose (40-60 mg/d, n = 36) of prednisone. There were no significant differences in baseline characteristics between the treatment groups including age, presenting symptoms and laboratory results. During a follow-up period of 6 months, in nearly all patients, symptoms (jaundice, weight loss) resolved completely. After 6 months, treatment response with respect to symptomatic, radiological, and laboratory improvement was comparable for the different dosage groups. Response to therapy was comparable for AIP patients treated with doses of prednisone in the range of 10 to 60 mg/d. A prospective trial should be conducted to confirm efficacy of lower-dose prednisone treatment
KW - autoimmune pancreatitis
KW - IgG4
KW - steroid therapy
UR - http://www.scopus.com/inward/record.url?scp=84894452095&partnerID=8YFLogxK
U2 - 10.1097/MPA.0000000000000044
DO - 10.1097/MPA.0000000000000044
M3 - Article
C2 - 24518506
SN - 0885-3177
VL - 43
SP - 261
EP - 267
JO - Pancreas
JF - Pancreas
IS - 2
ER -