Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence

Afroditi Katsarou; Maria Sjöstrand; Jyoti Naik; Jorge Mansilla-Soto; Dionysia Kefala; Georgios Kladis; Alexandros Nianias; Ruud Ruiter; Renée Poels; Irene Sarkar; Yash R. Patankar; Elena Merino; Rogier M. Reijmers; Kristine A. Frerichs; Huipin Yuan; Joost de Bruijn; Dina Stroopinsky; David Avigan; Niels W. C. J. van de Donk; Sonja Zweegman; Tuna Mutis; Michel Sadelain; Richard W. J. Groen; Maria Themeli

doi:10.1126/scitranslmed.abh1962

Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence

Afroditi Katsarou
, Maria Sjöstrand
, Jyoti Naik
, Jorge Mansilla-Soto
, Dionysia Kefala
, Georgios Kladis
, Alexandros Nianias
, Ruud Ruiter
, Renée Poels
, Irene Sarkar
, Yash R. Patankar
, Elena Merino
, Rogier M. Reijmers
, Kristine A. Frerichs
, Huipin Yuan
, Joost de Bruijn
, Dina Stroopinsky
, David Avigan
, Niels W. C. J. van de Donk
, Sonja Zweegman

Tuna Mutis, Michel Sadelain, Richard W. J. Groen, Maria Themeli

Amsterdam UMC - University of Amsterdam
Memorial Sloan-Kettering Cancer Center
Kuros Biosciences BV
Queen Mary University of London
Harvard University
University of Amsterdam
LUMICKS
Harvard Medical School

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

[Figure: see text].

Original language	English
Pages (from-to)	eabh1962
Journal	Science translational medicine
Volume	13
Issue number	623
DOIs	https://doi.org/10.1126/scitranslmed.abh1962
Publication status	Published - 8 Dec 2021

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SDG 3 Good Health and Well-being

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10.1126/scitranslmed.abh1962

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Katsarou, A., Sjöstrand, M., Naik, J., Mansilla-Soto, J., Kefala, D., Kladis, G., Nianias, A., Ruiter, R., Poels, R., Sarkar, I., Patankar, Y. R., Merino, E., Reijmers, R. M., Frerichs, K. A., Yuan, H., de Bruijn, J., Stroopinsky, D., Avigan, D., van de Donk, N. W. C. J., ... Themeli, M. (2021). Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence. Science translational medicine, 13(623), eabh1962. https://doi.org/10.1126/scitranslmed.abh1962

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author = "Afroditi Katsarou and Maria Sj{\"o}strand and Jyoti Naik and Jorge Mansilla-Soto and Dionysia Kefala and Georgios Kladis and Alexandros Nianias and Ruud Ruiter and Ren{\'e}e Poels and Irene Sarkar and Patankar, \{Yash R.\} and Elena Merino and Reijmers, \{Rogier M.\} and Frerichs, \{Kristine A.\} and Huipin Yuan and \{de Bruijn\}, Joost and Dina Stroopinsky and David Avigan and \{van de Donk\}, \{Niels W. C. J.\} and Sonja Zweegman and Tuna Mutis and Michel Sadelain and Groen, \{Richard W. J.\} and Maria Themeli",

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doi = "10.1126/scitranslmed.abh1962",

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Katsarou, A, Sjöstrand, M, Naik, J, Mansilla-Soto, J, Kefala, D, Kladis, G , Nianias, A, Ruiter, R, Poels, R, Sarkar, I, Patankar, YR, Merino, E, Reijmers, RM, Frerichs, KA, Yuan, H, de Bruijn, J, Stroopinsky, D, Avigan, D, van de Donk, NWCJ , Zweegman, S , Mutis, T, Sadelain, M, Groen, RWJ & Themeli, M 2021, 'Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence', Science translational medicine, vol. 13, no. 623, pp. eabh1962. https://doi.org/10.1126/scitranslmed.abh1962

TY - JOUR

T1 - Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence

AU - Katsarou, Afroditi

AU - Sjöstrand, Maria

AU - Naik, Jyoti

AU - Mansilla-Soto, Jorge

AU - Kefala, Dionysia

AU - Kladis, Georgios

AU - Nianias, Alexandros

AU - Ruiter, Ruud

AU - Poels, Renée

AU - Sarkar, Irene

AU - Patankar, Yash R.

AU - Merino, Elena

AU - Reijmers, Rogier M.

AU - Frerichs, Kristine A.

AU - Yuan, Huipin

AU - de Bruijn, Joost

AU - Stroopinsky, Dina

AU - Avigan, David

AU - van de Donk, Niels W. C. J.

AU - Zweegman, Sonja

AU - Mutis, Tuna

AU - Sadelain, Michel

AU - Groen, Richard W. J.

AU - Themeli, Maria

PY - 2021/12/8

Y1 - 2021/12/8

N2 - [Figure: see text].

AB - [Figure: see text].

UR - https://www.scopus.com/pages/publications/85122508000

U2 - 10.1126/scitranslmed.abh1962

DO - 10.1126/scitranslmed.abh1962

M3 - Article

C2 - 34878825

SN - 1946-6234

VL - 13

SP - eabh1962

JO - Science translational medicine

JF - Science translational medicine

IS - 623

ER -

Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence

Abstract

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