Colloidal bismuth subcitrate in peptic ulcer--a review

G. N. Tytgat

doi:10.1159/000199556

Colloidal bismuth subcitrate in peptic ulcer--a review

G. N. Tytgat

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

De-Nol (colloidal bismuth subcitrate, CBS) precipitates in an acid environment and adheres to the exudate layer covering an ulcer crater; moreover, CBS blocks pepsin activity, retards hydrogen-ion back-diffusion and stimulates prostaglandin synthesis. The average healing rate in duodenal ulcer (DU) after 4 weeks' treatment with CBS is 78% versus 63% with cimetidine. In a direct comparison, CBS gives 84% healing as opposed to 78% with ranitidine. The average healing rate after 4 weeks' treatment with CBS in gastric ulcer (GU) is 68% compared to 54% with cimetidine. The percentage of relapse-free patients, 1 year after DU or GU healing, with CBS is substantially higher than is the case with H2-receptor blockers

Original language	English
Pages (from-to)	31-41
Journal	Digestion
Volume	37
Issue number	Suppl. 2
DOIs	https://doi.org/10.1159/000199556
Publication status	Published - 1987

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@article{05f50297d18d417d83b35eb1bfb03ff8,

title = "Colloidal bismuth subcitrate in peptic ulcer--a review",

abstract = "De-Nol (colloidal bismuth subcitrate, CBS) precipitates in an acid environment and adheres to the exudate layer covering an ulcer crater; moreover, CBS blocks pepsin activity, retards hydrogen-ion back-diffusion and stimulates prostaglandin synthesis. The average healing rate in duodenal ulcer (DU) after 4 weeks' treatment with CBS is 78\% versus 63\% with cimetidine. In a direct comparison, CBS gives 84\% healing as opposed to 78\% with ranitidine. The average healing rate after 4 weeks' treatment with CBS in gastric ulcer (GU) is 68\% compared to 54\% with cimetidine. The percentage of relapse-free patients, 1 year after DU or GU healing, with CBS is substantially higher than is the case with H2-receptor blockers",

author = "Tytgat, \{G. N.\}",

year = "1987",

doi = "10.1159/000199556",

language = "English",

volume = "37",

pages = "31--41",

journal = "Digestion",

issn = "0012-2823",

publisher = "S. Karger AG",

number = "Suppl. 2",

}

TY - JOUR

T1 - Colloidal bismuth subcitrate in peptic ulcer--a review

AU - Tytgat, G. N.

PY - 1987

Y1 - 1987

N2 - De-Nol (colloidal bismuth subcitrate, CBS) precipitates in an acid environment and adheres to the exudate layer covering an ulcer crater; moreover, CBS blocks pepsin activity, retards hydrogen-ion back-diffusion and stimulates prostaglandin synthesis. The average healing rate in duodenal ulcer (DU) after 4 weeks' treatment with CBS is 78% versus 63% with cimetidine. In a direct comparison, CBS gives 84% healing as opposed to 78% with ranitidine. The average healing rate after 4 weeks' treatment with CBS in gastric ulcer (GU) is 68% compared to 54% with cimetidine. The percentage of relapse-free patients, 1 year after DU or GU healing, with CBS is substantially higher than is the case with H2-receptor blockers

AB - De-Nol (colloidal bismuth subcitrate, CBS) precipitates in an acid environment and adheres to the exudate layer covering an ulcer crater; moreover, CBS blocks pepsin activity, retards hydrogen-ion back-diffusion and stimulates prostaglandin synthesis. The average healing rate in duodenal ulcer (DU) after 4 weeks' treatment with CBS is 78% versus 63% with cimetidine. In a direct comparison, CBS gives 84% healing as opposed to 78% with ranitidine. The average healing rate after 4 weeks' treatment with CBS in gastric ulcer (GU) is 68% compared to 54% with cimetidine. The percentage of relapse-free patients, 1 year after DU or GU healing, with CBS is substantially higher than is the case with H2-receptor blockers

U2 - 10.1159/000199556

DO - 10.1159/000199556

M3 - Review article

C2 - 3305117

SN - 0012-2823

VL - 37

SP - 31

EP - 41

JO - Digestion

JF - Digestion

IS - Suppl. 2

ER -

Colloidal bismuth subcitrate in peptic ulcer--a review

Abstract

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