Clonal Patterns Between Pouch Neoplasia and Prior Colorectal Neoplasia in Inflammatory Bowel Disease Patients: An Exploratory Cohort Study

Maarten te Groen; Lauranne A. A. P. Derikx; Lisa van Lierop; Bauke Ylstra; Frank Hoentjen; Iris D. Nagtegaal; Femke Simmer

doi:10.1093/ibd/izad112

Clonal Patterns Between Pouch Neoplasia and Prior Colorectal Neoplasia in Inflammatory Bowel Disease Patients: An Exploratory Cohort Study

Maarten te Groen
, Lauranne A. A. P. Derikx
, Lisa van Lierop
, Bauke Ylstra
, Frank Hoentjen
, Iris D. Nagtegaal
, Femke Simmer

Radboud University Medical Center
Erasmus MC
Amsterdam UMC - University of Amsterdam
Department of Medicine and Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada
Radboud University Nijmegen
Erasmus University Rotterdam
Amsterdam University Medical Centers
Department of Medical Genetics, University of Alberta, Edmonton, Alberta, Canada.

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Abstract

Prior colorectal neoplasia is the strongest predictor of pouch neoplasia in inflammatory bowel disease, but the underlying mechanism is unknown. We observed clonality between colorectal and pouch neoplasia in 30% of patients, indicating that most pouch neoplasia develops clonally independent from prior colorectal lesions.

Original language	English
Pages (from-to)	1347-1351
Number of pages	5
Journal	Inflammatory bowel diseases
Volume	29
Issue number	8
DOIs	https://doi.org/10.1093/ibd/izad112
Publication status	Published - 1 Aug 2023

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title = "Clonal Patterns Between Pouch Neoplasia and Prior Colorectal Neoplasia in Inflammatory Bowel Disease Patients: An Exploratory Cohort Study",

abstract = "Prior colorectal neoplasia is the strongest predictor of pouch neoplasia in inflammatory bowel disease, but the underlying mechanism is unknown. We observed clonality between colorectal and pouch neoplasia in 30\% of patients, indicating that most pouch neoplasia develops clonally independent from prior colorectal lesions.",

author = "\{te Groen\}, Maarten and Derikx, \{Lauranne A. A. P.\} and \{van Lierop\}, Lisa and Bauke Ylstra and Frank Hoentjen and Nagtegaal, \{Iris D.\} and Femke Simmer",

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T2 - An Exploratory Cohort Study

AU - te Groen, Maarten

AU - Derikx, Lauranne A. A. P.

AU - van Lierop, Lisa

AU - Ylstra, Bauke

AU - Hoentjen, Frank

AU - Nagtegaal, Iris D.

AU - Simmer, Femke

PY - 2023/8/1

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N2 - Prior colorectal neoplasia is the strongest predictor of pouch neoplasia in inflammatory bowel disease, but the underlying mechanism is unknown. We observed clonality between colorectal and pouch neoplasia in 30% of patients, indicating that most pouch neoplasia develops clonally independent from prior colorectal lesions.

AB - Prior colorectal neoplasia is the strongest predictor of pouch neoplasia in inflammatory bowel disease, but the underlying mechanism is unknown. We observed clonality between colorectal and pouch neoplasia in 30% of patients, indicating that most pouch neoplasia develops clonally independent from prior colorectal lesions.

UR - https://www.scopus.com/pages/publications/85166385873

U2 - 10.1093/ibd/izad112

DO - 10.1093/ibd/izad112

M3 - Article

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SN - 1078-0998

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SP - 1347

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JO - Inflammatory bowel diseases

JF - Inflammatory bowel diseases

IS - 8

ER -

Clonal Patterns Between Pouch Neoplasia and Prior Colorectal Neoplasia in Inflammatory Bowel Disease Patients: An Exploratory Cohort Study

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