Clinical superficial Raman probe aimed for epithelial tumor detection: Phantom model results

Michelle Agenant; Matthijs Grimbergen; Ronald Draga; Eric Marple; Ruud Bosch; Christiaan van Swol

doi:10.1364/BOE.5.001203

Clinical superficial Raman probe aimed for epithelial tumor detection: Phantom model results

Michelle Agenant^*
, Matthijs Grimbergen
, Ronald Draga
, Eric Marple
, Ruud Bosch
, Christiaan van Swol

^*Corresponding author for this work

St. Antonius Ziekenhuis
Utrecht University
EmVision LLC

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A novel clinical Raman probe for sampling superficial tissue to improve in vivo detection of epithelial malignancies is compared to a nonsuperficial probe regarding depth response function and signal-to-noise ratio. Depth response measurements were performed in a phantom tissue model consisting of a polyethylene terephthalate disc in an 20%-Intralipid® solution. Sampling ranges of 0-200 and 0-300 μm were obtained for the superficial and non-superficial probe, respectively. The mean signal-to-noise ratio of the superficial probe increased by a factor of 2 compared with the non-superficial probe. This newly developed superficial Raman probe is expected to improve epithelial cancer detection in vivo.

Original language	English
Pages (from-to)	1203-1216
Number of pages	14
Journal	Biomedical optics express
Volume	5
Issue number	4
DOIs	https://doi.org/10.1364/BOE.5.001203
Publication status	Published - 1 Apr 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1364/BOE.5.001203

Cite this

@article{6e7713d9f29a465795fd0017b8c5b937,

title = "Clinical superficial Raman probe aimed for epithelial tumor detection: Phantom model results",

abstract = "A novel clinical Raman probe for sampling superficial tissue to improve in vivo detection of epithelial malignancies is compared to a nonsuperficial probe regarding depth response function and signal-to-noise ratio. Depth response measurements were performed in a phantom tissue model consisting of a polyethylene terephthalate disc in an 20\%-Intralipid{\textregistered} solution. Sampling ranges of 0-200 and 0-300 μm were obtained for the superficial and non-superficial probe, respectively. The mean signal-to-noise ratio of the superficial probe increased by a factor of 2 compared with the non-superficial probe. This newly developed superficial Raman probe is expected to improve epithelial cancer detection in vivo.",

author = "Michelle Agenant and Matthijs Grimbergen and Ronald Draga and Eric Marple and Ruud Bosch and \{van Swol\}, Christiaan",

year = "2014",

month = apr,

day = "1",

doi = "10.1364/BOE.5.001203",

language = "English",

volume = "5",

pages = "1203--1216",

journal = "Biomedical optics express",

issn = "2156-7085",

publisher = "Optica Publishing Group (formerly OSA)",

number = "4",

}

TY - JOUR

T1 - Clinical superficial Raman probe aimed for epithelial tumor detection

T2 - Phantom model results

AU - Agenant, Michelle

AU - Grimbergen, Matthijs

AU - Draga, Ronald

AU - Marple, Eric

AU - Bosch, Ruud

AU - van Swol, Christiaan

PY - 2014/4/1

Y1 - 2014/4/1

N2 - A novel clinical Raman probe for sampling superficial tissue to improve in vivo detection of epithelial malignancies is compared to a nonsuperficial probe regarding depth response function and signal-to-noise ratio. Depth response measurements were performed in a phantom tissue model consisting of a polyethylene terephthalate disc in an 20%-Intralipid® solution. Sampling ranges of 0-200 and 0-300 μm were obtained for the superficial and non-superficial probe, respectively. The mean signal-to-noise ratio of the superficial probe increased by a factor of 2 compared with the non-superficial probe. This newly developed superficial Raman probe is expected to improve epithelial cancer detection in vivo.

AB - A novel clinical Raman probe for sampling superficial tissue to improve in vivo detection of epithelial malignancies is compared to a nonsuperficial probe regarding depth response function and signal-to-noise ratio. Depth response measurements were performed in a phantom tissue model consisting of a polyethylene terephthalate disc in an 20%-Intralipid® solution. Sampling ranges of 0-200 and 0-300 μm were obtained for the superficial and non-superficial probe, respectively. The mean signal-to-noise ratio of the superficial probe increased by a factor of 2 compared with the non-superficial probe. This newly developed superficial Raman probe is expected to improve epithelial cancer detection in vivo.

UR - https://www.scopus.com/pages/publications/84896918965

U2 - 10.1364/BOE.5.001203

DO - 10.1364/BOE.5.001203

M3 - Article

SN - 2156-7085

VL - 5

SP - 1203

EP - 1216

JO - Biomedical optics express

JF - Biomedical optics express

IS - 4

ER -

Clinical superficial Raman probe aimed for epithelial tumor detection: Phantom model results

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this