Clinical predictors, biomarkers and pathogen discovery sequencing in suspected central nervous system infections

Central nervous system (CNS) infections are associated with high morbidity and mortality, depending on the causative pathogen. Virtually all pathogens can infect the brain or meninges surrounding it, including viruses, bacteria, fungi and parasites. The differential diagnosis in patients suspected of CNS infections is broad, and the diagnosis can be difficult to establish. Also, in a