Clinical impact of molecular analysis on thyroid cancer management

Volkert B. Wreesmann; Bhuvanesh Singh

doi:10.1016/j.soc.2007.10.013

Clinical impact of molecular analysis on thyroid cancer management

Volkert B. Wreesmann
, Bhuvanesh Singh

Affiliatie UvA

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Thyroid cancer constitutes a progressive continuum of disease ranging from indolent well-differentiated carcinomas to aggressive poorly differentiated carcinomas and universally fatal anaplastic carcinomas. The wide divergence in clinical behavior is poorly predicted for by current clinicopathological factors. Moreover, therapeutic armentarium against aggressive thyroid cancers remains limited. Recent studies have identified a range of molecular alterations in thyroid cancers. Clinical implications of the molecular alterations include their utility in diagnostic evaluation, staging and targeted treatment. Continued molecular analysis of thyroid cancers promises to increase our understanding of its biologic behavior and is expected to have further impact on its clinical management

Original language	English
Pages (from-to)	1-+
Journal	Surgical oncology clinics of North America
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/j.soc.2007.10.013
Publication status	Published - 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.soc.2007.10.013

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title = "Clinical impact of molecular analysis on thyroid cancer management",

abstract = "Thyroid cancer constitutes a progressive continuum of disease ranging from indolent well-differentiated carcinomas to aggressive poorly differentiated carcinomas and universally fatal anaplastic carcinomas. The wide divergence in clinical behavior is poorly predicted for by current clinicopathological factors. Moreover, therapeutic armentarium against aggressive thyroid cancers remains limited. Recent studies have identified a range of molecular alterations in thyroid cancers. Clinical implications of the molecular alterations include their utility in diagnostic evaluation, staging and targeted treatment. Continued molecular analysis of thyroid cancers promises to increase our understanding of its biologic behavior and is expected to have further impact on its clinical management",

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AU - Singh, Bhuvanesh

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AB - Thyroid cancer constitutes a progressive continuum of disease ranging from indolent well-differentiated carcinomas to aggressive poorly differentiated carcinomas and universally fatal anaplastic carcinomas. The wide divergence in clinical behavior is poorly predicted for by current clinicopathological factors. Moreover, therapeutic armentarium against aggressive thyroid cancers remains limited. Recent studies have identified a range of molecular alterations in thyroid cancers. Clinical implications of the molecular alterations include their utility in diagnostic evaluation, staging and targeted treatment. Continued molecular analysis of thyroid cancers promises to increase our understanding of its biologic behavior and is expected to have further impact on its clinical management

U2 - 10.1016/j.soc.2007.10.013

DO - 10.1016/j.soc.2007.10.013

M3 - Review article

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VL - 17

SP - 1-+

JO - Surgical oncology clinics of North America

JF - Surgical oncology clinics of North America

IS - 1

ER -

Clinical impact of molecular analysis on thyroid cancer management

Abstract

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