Cholera toxin but not pertussis toxin inhibits angiotensin II-enhanced contractions in the rat portal vein

Jisi Zhang; Jacques C. A. van Meel; Martin Pfaffendorf; Pieter A. van Zwieten

doi:10.1016/0014-2999(93)90415-E

Cholera toxin but not pertussis toxin inhibits angiotensin II-enhanced contractions in the rat portal vein

Jisi Zhang
, Jacques C. A. van Meel
, Martin Pfaffendorf
, Pieter A. van Zwieten

University of Amsterdam
Boehringer Ingelheim GmbH

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Angiotensin II (Ang II)-enhanced phasic contractions in the rat portal vein were concentration dependently inhibited by cholera toxin (0.1-10 μg/ml) and dibutyryl cyclic AMP (0.1-1 mM), but not by pertussis toxin (1 μg/ml), which suggests that Gi is not involved in the Ang II signal transduction pathway. It also seems likely that the effect of cholera toxin is due to its ability to increase cyclic AMP production through Gs. © 1993.

Original language	English
Pages (from-to)	95-97
Journal	European journal of pharmacology
Volume	230
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(93)90415-E
Publication status	Published - 5 Jan 1993
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/0014-2999(93)90415-E

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abstract = "Angiotensin II (Ang II)-enhanced phasic contractions in the rat portal vein were concentration dependently inhibited by cholera toxin (0.1-10 μg/ml) and dibutyryl cyclic AMP (0.1-1 mM), but not by pertussis toxin (1 μg/ml), which suggests that Gi is not involved in the Ang II signal transduction pathway. It also seems likely that the effect of cholera toxin is due to its ability to increase cyclic AMP production through Gs. {\textcopyright} 1993.",

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AU - Pfaffendorf, Martin

AU - van Zwieten, Pieter A.

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N2 - Angiotensin II (Ang II)-enhanced phasic contractions in the rat portal vein were concentration dependently inhibited by cholera toxin (0.1-10 μg/ml) and dibutyryl cyclic AMP (0.1-1 mM), but not by pertussis toxin (1 μg/ml), which suggests that Gi is not involved in the Ang II signal transduction pathway. It also seems likely that the effect of cholera toxin is due to its ability to increase cyclic AMP production through Gs. © 1993.

AB - Angiotensin II (Ang II)-enhanced phasic contractions in the rat portal vein were concentration dependently inhibited by cholera toxin (0.1-10 μg/ml) and dibutyryl cyclic AMP (0.1-1 mM), but not by pertussis toxin (1 μg/ml), which suggests that Gi is not involved in the Ang II signal transduction pathway. It also seems likely that the effect of cholera toxin is due to its ability to increase cyclic AMP production through Gs. © 1993.

UR - https://www.scopus.com/pages/publications/0027441381

UR - https://www.ncbi.nlm.nih.gov/pubmed/8381358

U2 - 10.1016/0014-2999(93)90415-E

DO - 10.1016/0014-2999(93)90415-E

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ER -

Cholera toxin but not pertussis toxin inhibits angiotensin II-enhanced contractions in the rat portal vein

Abstract

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