Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm

Lutske Lodewijk; Wouter P Kluijfhout; Jakob W Kist; Inge Stegeman; John T M Plukker; Els J Nieveen van Dijkum; H Jaap Bonjer; Nicole D Bouvy; Abbey Schepers; Johannes H W de Wilt; Romana T Netea-Maier; Jos A van der Hage; Jacobus W A Burger; Gavin Ho; Wayne S Lee; Wen T Shen; Anna Aronova; Rasa Zarnegar; Cassandre Benay; Elliot J Mitmaker; Mark S Sywak; Ahmad M Aniss; Schelto Kruijff; Benjamin James; Raymon H Grogan; Laurent Brunaud; Guillaume Hoch; Chiara Pandolfi; Daniel T Ruan; Michael D Jones; Marlon A Guerrero; Gerlof D Valk; Inne H M Borel Rinkes; Menno R Vriens

doi:10.1007/s00423-016-1393-4

Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm

Lutske Lodewijk
, Wouter P Kluijfhout
, Jakob W Kist
, Inge Stegeman
, John T M Plukker
, Els J Nieveen van Dijkum
, H Jaap Bonjer
, Nicole D Bouvy
, Abbey Schepers
, Johannes H W de Wilt
, Romana T Netea-Maier
, Jos A van der Hage
, Jacobus W A Burger
, Gavin Ho
, Wayne S Lee
, Wen T Shen
, Anna Aronova
, Rasa Zarnegar
, Cassandre Benay
, Elliot J Mitmaker

Mark S Sywak, Ahmad M Aniss, Schelto Kruijff, Benjamin James, Raymon H Grogan, Laurent Brunaud, Guillaume Hoch, Chiara Pandolfi, Daniel T Ruan, Michael D Jones, Marlon A Guerrero, Gerlof D Valk, Inne H M Borel Rinkes, Menno R Vriens

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584CG Utrecht, The Netherlands; Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584CG Utrecht, The Netherlands; Department of Translational Neuroscience...
Department of Vascular Medicine, Academic Medical Center, Amsterdam 1105AZ, the Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen 9713ZG, the Netherlands; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen 9713ZG, the Netherlands; Amsterdam Diabetes Research Center,AMC...
Trauma Unit, Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands; Neurosurgical Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands; Trauma Unit, Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands. Electronic address: [email protected].
*Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands †NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands ‡MHeNs School of Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands ...
Department of Radiology CS2, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands. Electronic address: [email protected].
Radboud University Medical Center, Radboud Institute for Health Sciences, IQ healthcare, Nijmegen; and Radboud University Medical Center, Department of Primary and Community Care, Nijmegen, the Netherlands.
Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Cancer Systems Biology Center (CSBC), The Netherlands Cancer Institute, Amsterdam, the Netherlands. The NKI Robotics and Screening Center (NRSC), The Netherlands Cancer Institute, Amsterdam, the Netherlands. [email protected].
Erasmus Center for Biomics, Erasmus Medical Center, Rotterdam, The Netherlands.
Department of Psychiatry, University of California, San Francisco, California; San Francisco Veterans Affairs Medical Center, San Francisco, California.
Weill Cornell Medical Center
Montreal Neurological Institute and McGill University Health Centre, McGill University, Montreal, QC, Canada.
Sydney School of Public Health, Sydney Medical School, University of Sydney, Sydney, Australia.
William A. Stokes, Michael R. Bronsert, Robert A. Meguid, Bernard L. Jones, Laurie E. Gaspar, Brian D. Kavanagh, and Chad G. Rusthoven, University of Colorado School of Medicine, Aurora; Matthew G. Blum, Memorial Hospital, Colorado Springs, CO; Matthew Koshy, University of Chicago School of Medicine, Chicago, IL; David J. Sher, University of Texas Southwestern School of Medicine...
Centre Hospitalier Universitaire Nancy
Brigham and Women’s Hospital
The University of Arizona Medical Center

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

PURPOSE: Traditionally, total thyroidectomy has been advocated for patients with tumors larger than 1 cm. However, according to the ATA and NCCN guidelines (2015, USA), patients with tumors up to 4 cm are now eligible for lobectomy. A rationale for adhering to total thyroidectomy might be the presence of contralateral carcinomas. The purpose of this study was to describe the characteristics of contralateral carcinomas in patients with differentiated thyroid cancer (DTC) larger than 1 cm.

METHODS: A retrospective study was performed including patients from 17 centers in 5 countries. Adults diagnosed with DTC stage T1b-T3 N0-1a M0 who all underwent a total thyroidectomy were included. The primary endpoint was the presence of a contralateral carcinoma.

RESULTS: A total of 1313 patients were included, of whom 426 (32 %) had a contralateral carcinoma. The contralateral carcinomas consisted of 288 (67 %) papillary thyroid carcinomas (PTC), 124 (30 %) follicular variant of a papillary thyroid carcinoma (FvPTC), 5 (1 %) follicular thyroid carcinomas (FTC), and 3 (1 %) Hürthle cell carcinomas (HTC). Ipsilateral multifocality was strongly associated with the presence of contralateral carcinomas (OR 2.62). Of all contralateral carcinomas, 82 % were ≤10 mm and of those 99 % were PTC or FvPTC. Even if the primary tumor was a FTC or HTC, the contralateral carcinoma was (Fv)PTC in 92 % of cases.

CONCLUSIONS: This international multicenter study performed on patients with DTC larger than 1 cm shows that contralateral carcinomas occur in one third of patients and, independently of primary tumor subtype, predominantly consist of microPTC.

Original language	English
Pages (from-to)	365-73
Number of pages	9
Journal	Langenbeck's Archives of Surgery
Volume	401
Issue number	3
DOIs	https://doi.org/10.1007/s00423-016-1393-4
Publication status	Published - May 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adult
Aged
Carcinoma/epidemiology
Cross-Sectional Studies
Female
Humans
Incidence
Male
Middle Aged
Neoplasm Invasiveness
Neoplasms, Multiple Primary/epidemiology
Retrospective Studies
Thyroid Neoplasms/epidemiology
Thyroidectomy
Tumor Burden

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Characteristics-of-contralateral-carcinomas-in-patients-with-differentiated-thyroid-cancer-larger-than-1-cm.pdfFinal published version, 317 KBLicence: Taverne

Cite this

Lodewijk, L., Kluijfhout, W. P., Kist, J. W., Stegeman, I., Plukker, J. T. M., Nieveen van Dijkum, E. J., Bonjer, H. J., Bouvy, N. D., Schepers, A., de Wilt, J. H. W., Netea-Maier, R. T., van der Hage, J. A., Burger, J. W. A., Ho, G., Lee, W. S., Shen, W. T., Aronova, A., Zarnegar, R., Benay, C., ... Vriens, M. R. (2016). Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm. Langenbeck's Archives of Surgery, 401(3), 365-73. https://doi.org/10.1007/s00423-016-1393-4

@article{4a9e9d99fbec44fdb58531b299fb8073,

title = "Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm",

abstract = "PURPOSE: Traditionally, total thyroidectomy has been advocated for patients with tumors larger than 1 cm. However, according to the ATA and NCCN guidelines (2015, USA), patients with tumors up to 4 cm are now eligible for lobectomy. A rationale for adhering to total thyroidectomy might be the presence of contralateral carcinomas. The purpose of this study was to describe the characteristics of contralateral carcinomas in patients with differentiated thyroid cancer (DTC) larger than 1 cm.METHODS: A retrospective study was performed including patients from 17 centers in 5 countries. Adults diagnosed with DTC stage T1b-T3 N0-1a M0 who all underwent a total thyroidectomy were included. The primary endpoint was the presence of a contralateral carcinoma.RESULTS: A total of 1313 patients were included, of whom 426 (32 \%) had a contralateral carcinoma. The contralateral carcinomas consisted of 288 (67 \%) papillary thyroid carcinomas (PTC), 124 (30 \%) follicular variant of a papillary thyroid carcinoma (FvPTC), 5 (1 \%) follicular thyroid carcinomas (FTC), and 3 (1 \%) H{\"u}rthle cell carcinomas (HTC). Ipsilateral multifocality was strongly associated with the presence of contralateral carcinomas (OR 2.62). Of all contralateral carcinomas, 82 \% were ≤10 mm and of those 99 \% were PTC or FvPTC. Even if the primary tumor was a FTC or HTC, the contralateral carcinoma was (Fv)PTC in 92 \% of cases.CONCLUSIONS: This international multicenter study performed on patients with DTC larger than 1 cm shows that contralateral carcinomas occur in one third of patients and, independently of primary tumor subtype, predominantly consist of microPTC.",

keywords = "Adult, Aged, Carcinoma/epidemiology, Cross-Sectional Studies, Female, Humans, Incidence, Male, Middle Aged, Neoplasm Invasiveness, Neoplasms, Multiple Primary/epidemiology, Retrospective Studies, Thyroid Neoplasms/epidemiology, Thyroidectomy, Tumor Burden",

author = "Lutske Lodewijk and Kluijfhout, \{Wouter P\} and Kist, \{Jakob W\} and Inge Stegeman and Plukker, \{John T M\} and \{Nieveen van Dijkum\}, \{Els J\} and Bonjer, \{H Jaap\} and Bouvy, \{Nicole D\} and Abbey Schepers and \{de Wilt\}, \{Johannes H W\} and Netea-Maier, \{Romana T\} and \{van der Hage\}, \{Jos A\} and Burger, \{Jacobus W A\} and Gavin Ho and Lee, \{Wayne S\} and Shen, \{Wen T\} and Anna Aronova and Rasa Zarnegar and Cassandre Benay and Mitmaker, \{Elliot J\} and Sywak, \{Mark S\} and Aniss, \{Ahmad M\} and Schelto Kruijff and Benjamin James and Grogan, \{Raymon H\} and Laurent Brunaud and Guillaume Hoch and Chiara Pandolfi and Ruan, \{Daniel T\} and Jones, \{Michael D\} and Guerrero, \{Marlon A\} and Valk, \{Gerlof D\} and \{Borel Rinkes\}, \{Inne H M\} and Vriens, \{Menno R\}",

year = "2016",

month = may,

doi = "10.1007/s00423-016-1393-4",

language = "English",

volume = "401",

pages = "365--73",

journal = "Langenbeck's Archives of Surgery",

issn = "1435-2443",

publisher = "Springer Verlag",

number = "3",

}

Lodewijk, L, Kluijfhout, WP, Kist, JW, Stegeman, I, Plukker, JTM, Nieveen van Dijkum, EJ, Bonjer, HJ, Bouvy, ND, Schepers, A, de Wilt, JHW, Netea-Maier, RT, van der Hage, JA, Burger, JWA, Ho, G, Lee, WS, Shen, WT, Aronova, A, Zarnegar, R, Benay, C, Mitmaker, EJ, Sywak, MS, Aniss, AM, Kruijff, S, James, B, Grogan, RH, Brunaud, L, Hoch, G, Pandolfi, C, Ruan, DT, Jones, MD, Guerrero, MA, Valk, GD, Borel Rinkes, IHM & Vriens, MR 2016, 'Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm', Langenbeck's Archives of Surgery, vol. 401, no. 3, pp. 365-73. https://doi.org/10.1007/s00423-016-1393-4

TY - JOUR

T1 - Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm

AU - Lodewijk, Lutske

AU - Kluijfhout, Wouter P

AU - Kist, Jakob W

AU - Stegeman, Inge

AU - Plukker, John T M

AU - Nieveen van Dijkum, Els J

AU - Bonjer, H Jaap

AU - Bouvy, Nicole D

AU - Schepers, Abbey

AU - de Wilt, Johannes H W

AU - Netea-Maier, Romana T

AU - van der Hage, Jos A

AU - Burger, Jacobus W A

AU - Ho, Gavin

AU - Lee, Wayne S

AU - Shen, Wen T

AU - Aronova, Anna

AU - Zarnegar, Rasa

AU - Benay, Cassandre

AU - Mitmaker, Elliot J

AU - Sywak, Mark S

AU - Aniss, Ahmad M

AU - Kruijff, Schelto

AU - James, Benjamin

AU - Grogan, Raymon H

AU - Brunaud, Laurent

AU - Hoch, Guillaume

AU - Pandolfi, Chiara

AU - Ruan, Daniel T

AU - Jones, Michael D

AU - Guerrero, Marlon A

AU - Valk, Gerlof D

AU - Borel Rinkes, Inne H M

AU - Vriens, Menno R

PY - 2016/5

Y1 - 2016/5

N2 - PURPOSE: Traditionally, total thyroidectomy has been advocated for patients with tumors larger than 1 cm. However, according to the ATA and NCCN guidelines (2015, USA), patients with tumors up to 4 cm are now eligible for lobectomy. A rationale for adhering to total thyroidectomy might be the presence of contralateral carcinomas. The purpose of this study was to describe the characteristics of contralateral carcinomas in patients with differentiated thyroid cancer (DTC) larger than 1 cm.METHODS: A retrospective study was performed including patients from 17 centers in 5 countries. Adults diagnosed with DTC stage T1b-T3 N0-1a M0 who all underwent a total thyroidectomy were included. The primary endpoint was the presence of a contralateral carcinoma.RESULTS: A total of 1313 patients were included, of whom 426 (32 %) had a contralateral carcinoma. The contralateral carcinomas consisted of 288 (67 %) papillary thyroid carcinomas (PTC), 124 (30 %) follicular variant of a papillary thyroid carcinoma (FvPTC), 5 (1 %) follicular thyroid carcinomas (FTC), and 3 (1 %) Hürthle cell carcinomas (HTC). Ipsilateral multifocality was strongly associated with the presence of contralateral carcinomas (OR 2.62). Of all contralateral carcinomas, 82 % were ≤10 mm and of those 99 % were PTC or FvPTC. Even if the primary tumor was a FTC or HTC, the contralateral carcinoma was (Fv)PTC in 92 % of cases.CONCLUSIONS: This international multicenter study performed on patients with DTC larger than 1 cm shows that contralateral carcinomas occur in one third of patients and, independently of primary tumor subtype, predominantly consist of microPTC.

AB - PURPOSE: Traditionally, total thyroidectomy has been advocated for patients with tumors larger than 1 cm. However, according to the ATA and NCCN guidelines (2015, USA), patients with tumors up to 4 cm are now eligible for lobectomy. A rationale for adhering to total thyroidectomy might be the presence of contralateral carcinomas. The purpose of this study was to describe the characteristics of contralateral carcinomas in patients with differentiated thyroid cancer (DTC) larger than 1 cm.METHODS: A retrospective study was performed including patients from 17 centers in 5 countries. Adults diagnosed with DTC stage T1b-T3 N0-1a M0 who all underwent a total thyroidectomy were included. The primary endpoint was the presence of a contralateral carcinoma.RESULTS: A total of 1313 patients were included, of whom 426 (32 %) had a contralateral carcinoma. The contralateral carcinomas consisted of 288 (67 %) papillary thyroid carcinomas (PTC), 124 (30 %) follicular variant of a papillary thyroid carcinoma (FvPTC), 5 (1 %) follicular thyroid carcinomas (FTC), and 3 (1 %) Hürthle cell carcinomas (HTC). Ipsilateral multifocality was strongly associated with the presence of contralateral carcinomas (OR 2.62). Of all contralateral carcinomas, 82 % were ≤10 mm and of those 99 % were PTC or FvPTC. Even if the primary tumor was a FTC or HTC, the contralateral carcinoma was (Fv)PTC in 92 % of cases.CONCLUSIONS: This international multicenter study performed on patients with DTC larger than 1 cm shows that contralateral carcinomas occur in one third of patients and, independently of primary tumor subtype, predominantly consist of microPTC.

KW - Adult

KW - Aged

KW - Carcinoma/epidemiology

KW - Cross-Sectional Studies

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Neoplasm Invasiveness

KW - Neoplasms, Multiple Primary/epidemiology

KW - Retrospective Studies

KW - Thyroid Neoplasms/epidemiology

KW - Thyroidectomy

KW - Tumor Burden

U2 - 10.1007/s00423-016-1393-4

DO - 10.1007/s00423-016-1393-4

M3 - Article

C2 - 27013326

SN - 1435-2443

VL - 401

SP - 365

EP - 373

JO - Langenbeck's Archives of Surgery

JF - Langenbeck's Archives of Surgery

IS - 3

ER -

Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm

Abstract

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Keywords

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