Characteristics of clinical Helicobacter pylori strains from Ecuador

Yvette J. Debets-Ossenkopp; Germán Reyes; Janet Mulder; Birgit M. aan de Stegge; José T. A. M. Peters; Paul H. M. Savelkoul; J. Tanca; Amado S. Peña; Christina M. J. E. Vandenbroucke-Grauls

doi:10.1093/jac/dkg023

Characteristics of clinical Helicobacter pylori strains from Ecuador

Yvette J. Debets-Ossenkopp
, Germán Reyes
, Janet Mulder
, Birgit M. aan de Stegge
, José T. A. M. Peters
, Paul H. M. Savelkoul
, J. Tanca
, Amado S. Peña
, Christina M. J. E. Vandenbroucke-Grauls

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In Ecuador, Helicobacter pylori infections are highly prevalent. A total of 42 H. pylori clinical isolates from 86 patients attending the outpatient clinic of the gastroenterology department of the university hospital of Guayaquil in Ecuador were characterized. Their susceptibility, and cagA and vacA status were determined. Resistance to metronidazole and clarithromycin was found in 80.9% and 9.5% of strains, respectively. Neither amoxicillin- nor tetracycline-resistant strains were found. The most prevalent genotype was the cagA(+), vacA s1b,m1 type. This genotype was associated with gastric cancer and peptic ulcer. Typing by random amplified polymorphic DNA showed no genetic relationship among the strains

Original language	English
Pages (from-to)	141-145
Journal	Journal of antimicrobial chemotherapy
Volume	51
Issue number	1
DOIs	https://doi.org/10.1093/jac/dkg023
Publication status	Published - 2003

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title = "Characteristics of clinical Helicobacter pylori strains from Ecuador",

abstract = "In Ecuador, Helicobacter pylori infections are highly prevalent. A total of 42 H. pylori clinical isolates from 86 patients attending the outpatient clinic of the gastroenterology department of the university hospital of Guayaquil in Ecuador were characterized. Their susceptibility, and cagA and vacA status were determined. Resistance to metronidazole and clarithromycin was found in 80.9\% and 9.5\% of strains, respectively. Neither amoxicillin- nor tetracycline-resistant strains were found. The most prevalent genotype was the cagA(+), vacA s1b,m1 type. This genotype was associated with gastric cancer and peptic ulcer. Typing by random amplified polymorphic DNA showed no genetic relationship among the strains",

author = "Debets-Ossenkopp, \{Yvette J.\} and Germ{\'a}n Reyes and Janet Mulder and \{aan de Stegge\}, \{Birgit M.\} and Peters, \{Jos{\'e} T. A. M.\} and Savelkoul, \{Paul H. M.\} and J. Tanca and Pe{\~n}a, \{Amado S.\} and Vandenbroucke-Grauls, \{Christina M. J. E.\}",

year = "2003",

doi = "10.1093/jac/dkg023",

language = "English",

volume = "51",

pages = "141--145",

journal = "Journal of antimicrobial chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Characteristics of clinical Helicobacter pylori strains from Ecuador

AU - Debets-Ossenkopp, Yvette J.

AU - Reyes, Germán

AU - Mulder, Janet

AU - aan de Stegge, Birgit M.

AU - Peters, José T. A. M.

AU - Savelkoul, Paul H. M.

AU - Tanca, J.

AU - Peña, Amado S.

AU - Vandenbroucke-Grauls, Christina M. J. E.

PY - 2003

Y1 - 2003

N2 - In Ecuador, Helicobacter pylori infections are highly prevalent. A total of 42 H. pylori clinical isolates from 86 patients attending the outpatient clinic of the gastroenterology department of the university hospital of Guayaquil in Ecuador were characterized. Their susceptibility, and cagA and vacA status were determined. Resistance to metronidazole and clarithromycin was found in 80.9% and 9.5% of strains, respectively. Neither amoxicillin- nor tetracycline-resistant strains were found. The most prevalent genotype was the cagA(+), vacA s1b,m1 type. This genotype was associated with gastric cancer and peptic ulcer. Typing by random amplified polymorphic DNA showed no genetic relationship among the strains

AB - In Ecuador, Helicobacter pylori infections are highly prevalent. A total of 42 H. pylori clinical isolates from 86 patients attending the outpatient clinic of the gastroenterology department of the university hospital of Guayaquil in Ecuador were characterized. Their susceptibility, and cagA and vacA status were determined. Resistance to metronidazole and clarithromycin was found in 80.9% and 9.5% of strains, respectively. Neither amoxicillin- nor tetracycline-resistant strains were found. The most prevalent genotype was the cagA(+), vacA s1b,m1 type. This genotype was associated with gastric cancer and peptic ulcer. Typing by random amplified polymorphic DNA showed no genetic relationship among the strains

U2 - 10.1093/jac/dkg023

DO - 10.1093/jac/dkg023

M3 - Article

C2 - 12493799

SN - 0305-7453

VL - 51

SP - 141

EP - 145

JO - Journal of antimicrobial chemotherapy

JF - Journal of antimicrobial chemotherapy

IS - 1

ER -

Characteristics of clinical Helicobacter pylori strains from Ecuador

Abstract

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