Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19

Adrian Scutelnic; Anita van de Munckhof; Angel T. Miraclin; Sanjith Aaron; Sajid Hameed; Mohammad Wasay; Oxana Grosu; Katarzyna Krzywicka; Mayte Sánchez van Kammen; Erik Lindgren; Tiago Moreira; Roberto Acampora; Alberto Negro; Theodoros Karapanayiotides; Shadi Yaghi; Anna Revert; Elisa Cuadrado Godia; Sebastian Garcia-Madrona; Paolino la Spina; Francesco Grillo; Fabrizio Giammello; Thanh N. Nguyen; Mohamad Abdalkader; Alina Buture; Maria Sofia Cotelli; Nicolas Raposo; Georgios Tsivgoulis; Paolo Candelaresi; Antonio Ciacciarelli; Joshua Mbroh; Tatiana Batenkova; Pasquale Scoppettuolo; Marialuisa Zedde; Rosario Pascarella; Kateryna Antonenko; Espen S. Kristoffersen; Johanna A. Kremer Hovinga; Katarina Jood; Diana Aguiar de Sousa; Sven Poli; Turgut Tatlisumak; Jukka Putaala; Jonathan M. Coutinho; José M. Ferro; Marcel Arnold; Mirjam R. Heldner

doi:10.1177/23969873241241885

Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19

Adrian Scutelnic
, Anita van de Munckhof
, Angel T. Miraclin
, Sanjith Aaron
, Sajid Hameed
, Mohammad Wasay
, Oxana Grosu
, Katarzyna Krzywicka
, Mayte Sánchez van Kammen
, Erik Lindgren
, Tiago Moreira
, Roberto Acampora
, Alberto Negro
, Theodoros Karapanayiotides
, Shadi Yaghi
, Anna Revert
, Elisa Cuadrado Godia
, Sebastian Garcia-Madrona
, Paolino la Spina
, Francesco Grillo

Fabrizio Giammello, Thanh N. Nguyen, Mohamad Abdalkader, Alina Buture, Maria Sofia Cotelli, Nicolas Raposo, Georgios Tsivgoulis, Paolo Candelaresi, Antonio Ciacciarelli, Joshua Mbroh, Tatiana Batenkova, Pasquale Scoppettuolo, Marialuisa Zedde, Rosario Pascarella, Kateryna Antonenko, Espen S. Kristoffersen, Johanna A. Kremer Hovinga, Katarina Jood, Diana Aguiar de Sousa, Sven Poli, Turgut Tatlisumak, Jukka Putaala, Jonathan M. Coutinho, José M. Ferro, Marcel Arnold, Mirjam R. Heldner^*

^*Corresponding author for this work

University of Bern
Christian Medical College
Aga Khan University
Institute of Neurology and Neurosurgery “Diomid Gherman,” Chisinau
Sahlgrenska University Hospital
University of Gothenburg
Karolinska Institutet
Ospedale del Mare Hospital
Aristotle University of Thessaloniki
Brown University
Pompeu Fabra University
Hospital Ramon y Cajal
University of Messina
Boston University
University College Dublin
ASST Valcamonica Ospedale Di Esine, Esine, Italy
CHU de Toulouse
Athens University Medical School
Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli
Santa Maria Goretti Hospital
University of Rome La Sapienza
University of Tübingen
Sverdlovsk Regional Clinical Hospital No. 1
Université catholique de Louvain
Epidemiology Unit, 42122, Italy
University of Oslo
University of Lisbon
Helsinki University Hospital
Centro de Estudos Egas Moniz

Research output: Contribution to journal › Article › Academic › peer-review

37 Downloads (Pure)

Abstract

Introduction: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT. Patients and methods: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison. Outcome analyses were adjusted for age and sex. Results: We included 70 patients with COVID-CVT from 23 hospitals in 15 countries and 206 controls from 14 hospitals in 13 countries. The proportion of women was smaller in the COVID-CVT group (50% vs 68%, p < 0.01). A higher proportion of COVID-CVT patients presented with altered mental state (44% vs 25%, p < 0.01), the median thrombus load was higher in COVID-CVT patients (3 [IQR 2–4] vs 2 [1–3], p < 0.01) and the length of hospital stay was longer compared to controls (11 days [IQR 7–20] vs 8 [4–15], p = 0.02). In-hospital mortality did not differ (5/67 [7%, 95% CI 3–16] vs 7/206 [3%, 2–7], aOR 2.6 [95% CI 0.7–9]), nor did the frequency of functional independence after 6 months (modified Rankin Scale 0–2; 45/58 [78%, 95% CI 65–86] vs 161/185 [87%, 81–91], aOR 0.5 [95% CI 0.2–1.02]). Conclusion: In contrast to previous studies, the in-hospital mortality rate and functional outcomes during follow-up did not differ between COVID-CVT patients and the pre-COVID-19 controls.

Original language	English
Pages (from-to)	676-686
Number of pages	11
Journal	European Stroke Journal
Volume	9
Issue number	3
Early online date	4 Apr 2024
DOIs	https://doi.org/10.1177/23969873241241885
Publication status	Published - Sept 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19
Cerebral venous thrombosis
stroke

Access to Document

10.1177/23969873241241885

Characteristics-and-outcomes-of-cerebral-venous-thrombosis-associated-with-covid-19.pdfFinal published version, 588 KB

Cite this

Scutelnic, A., van de Munckhof, A., Miraclin, A. T., Aaron, S., Hameed, S., Wasay, M., Grosu, O., Krzywicka, K., Sánchez van Kammen, M., Lindgren, E., Moreira, T., Acampora, R., Negro, A., Karapanayiotides, T., Yaghi, S., Revert, A., Cuadrado Godia, E., Garcia-Madrona, S., la Spina, P., ... Heldner, M. R. (2024). Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19. European Stroke Journal, 9(3), 676-686. https://doi.org/10.1177/23969873241241885

@article{739bc7342dd943cabac90440b5602b1f,

title = "Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19",

abstract = "Introduction: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40\% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT. Patients and methods: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison. Outcome analyses were adjusted for age and sex. Results: We included 70 patients with COVID-CVT from 23 hospitals in 15 countries and 206 controls from 14 hospitals in 13 countries. The proportion of women was smaller in the COVID-CVT group (50\% vs 68\%, p < 0.01). A higher proportion of COVID-CVT patients presented with altered mental state (44\% vs 25\%, p < 0.01), the median thrombus load was higher in COVID-CVT patients (3 [IQR 2–4] vs 2 [1–3], p < 0.01) and the length of hospital stay was longer compared to controls (11 days [IQR 7–20] vs 8 [4–15], p = 0.02). In-hospital mortality did not differ (5/67 [7\%, 95\% CI 3–16] vs 7/206 [3\%, 2–7], aOR 2.6 [95\% CI 0.7–9]), nor did the frequency of functional independence after 6 months (modified Rankin Scale 0–2; 45/58 [78\%, 95\% CI 65–86] vs 161/185 [87\%, 81–91], aOR 0.5 [95\% CI 0.2–1.02]). Conclusion: In contrast to previous studies, the in-hospital mortality rate and functional outcomes during follow-up did not differ between COVID-CVT patients and the pre-COVID-19 controls.",

keywords = "COVID-19, Cerebral venous thrombosis, stroke",

author = "Adrian Scutelnic and \{van de Munckhof\}, Anita and Miraclin, \{Angel T.\} and Sanjith Aaron and Sajid Hameed and Mohammad Wasay and Oxana Grosu and Katarzyna Krzywicka and \{S{\'a}nchez van Kammen\}, Mayte and Erik Lindgren and Tiago Moreira and Roberto Acampora and Alberto Negro and Theodoros Karapanayiotides and Shadi Yaghi and Anna Revert and \{Cuadrado Godia\}, Elisa and Sebastian Garcia-Madrona and \{la Spina\}, Paolino and Francesco Grillo and Fabrizio Giammello and Nguyen, \{Thanh N.\} and Mohamad Abdalkader and Alina Buture and \{Sofia Cotelli\}, Maria and Nicolas Raposo and Georgios Tsivgoulis and Paolo Candelaresi and Antonio Ciacciarelli and Joshua Mbroh and Tatiana Batenkova and Pasquale Scoppettuolo and Marialuisa Zedde and Rosario Pascarella and Kateryna Antonenko and Kristoffersen, \{Espen S.\} and \{Kremer Hovinga\}, \{Johanna A.\} and Katarina Jood and \{Aguiar de Sousa\}, Diana and Sven Poli and Turgut Tatlisumak and Jukka Putaala and Coutinho, \{Jonathan M.\} and Ferro, \{Jos{\'e} M.\} and Marcel Arnold and Heldner, \{Mirjam R.\}",

note = "Publisher Copyright: {\textcopyright} European Stroke Organisation 2024.",

year = "2024",

month = sep,

doi = "10.1177/23969873241241885",

language = "English",

volume = "9",

pages = "676--686",

journal = "European Stroke Journal",

issn = "2396-9873",

publisher = "SAGE Publications Inc.",

number = "3",

}

Scutelnic, A, van de Munckhof, A, Miraclin, AT, Aaron, S, Hameed, S, Wasay, M, Grosu, O, Krzywicka, K , Sánchez van Kammen, M, Lindgren, E, Moreira, T, Acampora, R, Negro, A, Karapanayiotides, T, Yaghi, S, Revert, A, Cuadrado Godia, E, Garcia-Madrona, S, la Spina, P, Grillo, F, Giammello, F, Nguyen, TN, Abdalkader, M, Buture, A, Sofia Cotelli, M, Raposo, N, Tsivgoulis, G, Candelaresi, P, Ciacciarelli, A, Mbroh, J, Batenkova, T, Scoppettuolo, P, Zedde, M, Pascarella, R, Antonenko, K, Kristoffersen, ES, Kremer Hovinga, JA, Jood, K, Aguiar de Sousa, D, Poli, S, Tatlisumak, T, Putaala, J, Coutinho, JM, Ferro, JM, Arnold, M & Heldner, MR 2024, 'Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19', European Stroke Journal, vol. 9, no. 3, pp. 676-686. https://doi.org/10.1177/23969873241241885

TY - JOUR

T1 - Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19

AU - Scutelnic, Adrian

AU - van de Munckhof, Anita

AU - Miraclin, Angel T.

AU - Aaron, Sanjith

AU - Hameed, Sajid

AU - Wasay, Mohammad

AU - Grosu, Oxana

AU - Krzywicka, Katarzyna

AU - Sánchez van Kammen, Mayte

AU - Lindgren, Erik

AU - Moreira, Tiago

AU - Acampora, Roberto

AU - Negro, Alberto

AU - Karapanayiotides, Theodoros

AU - Yaghi, Shadi

AU - Revert, Anna

AU - Cuadrado Godia, Elisa

AU - Garcia-Madrona, Sebastian

AU - la Spina, Paolino

AU - Grillo, Francesco

AU - Giammello, Fabrizio

AU - Nguyen, Thanh N.

AU - Abdalkader, Mohamad

AU - Buture, Alina

AU - Sofia Cotelli, Maria

AU - Raposo, Nicolas

AU - Tsivgoulis, Georgios

AU - Candelaresi, Paolo

AU - Ciacciarelli, Antonio

AU - Mbroh, Joshua

AU - Batenkova, Tatiana

AU - Scoppettuolo, Pasquale

AU - Zedde, Marialuisa

AU - Pascarella, Rosario

AU - Antonenko, Kateryna

AU - Kristoffersen, Espen S.

AU - Kremer Hovinga, Johanna A.

AU - Jood, Katarina

AU - Aguiar de Sousa, Diana

AU - Poli, Sven

AU - Tatlisumak, Turgut

AU - Putaala, Jukka

AU - Coutinho, Jonathan M.

AU - Ferro, José M.

AU - Arnold, Marcel

AU - Heldner, Mirjam R.

PY - 2024/9

Y1 - 2024/9

N2 - Introduction: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT. Patients and methods: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison. Outcome analyses were adjusted for age and sex. Results: We included 70 patients with COVID-CVT from 23 hospitals in 15 countries and 206 controls from 14 hospitals in 13 countries. The proportion of women was smaller in the COVID-CVT group (50% vs 68%, p < 0.01). A higher proportion of COVID-CVT patients presented with altered mental state (44% vs 25%, p < 0.01), the median thrombus load was higher in COVID-CVT patients (3 [IQR 2–4] vs 2 [1–3], p < 0.01) and the length of hospital stay was longer compared to controls (11 days [IQR 7–20] vs 8 [4–15], p = 0.02). In-hospital mortality did not differ (5/67 [7%, 95% CI 3–16] vs 7/206 [3%, 2–7], aOR 2.6 [95% CI 0.7–9]), nor did the frequency of functional independence after 6 months (modified Rankin Scale 0–2; 45/58 [78%, 95% CI 65–86] vs 161/185 [87%, 81–91], aOR 0.5 [95% CI 0.2–1.02]). Conclusion: In contrast to previous studies, the in-hospital mortality rate and functional outcomes during follow-up did not differ between COVID-CVT patients and the pre-COVID-19 controls.

AB - Introduction: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT. Patients and methods: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison. Outcome analyses were adjusted for age and sex. Results: We included 70 patients with COVID-CVT from 23 hospitals in 15 countries and 206 controls from 14 hospitals in 13 countries. The proportion of women was smaller in the COVID-CVT group (50% vs 68%, p < 0.01). A higher proportion of COVID-CVT patients presented with altered mental state (44% vs 25%, p < 0.01), the median thrombus load was higher in COVID-CVT patients (3 [IQR 2–4] vs 2 [1–3], p < 0.01) and the length of hospital stay was longer compared to controls (11 days [IQR 7–20] vs 8 [4–15], p = 0.02). In-hospital mortality did not differ (5/67 [7%, 95% CI 3–16] vs 7/206 [3%, 2–7], aOR 2.6 [95% CI 0.7–9]), nor did the frequency of functional independence after 6 months (modified Rankin Scale 0–2; 45/58 [78%, 95% CI 65–86] vs 161/185 [87%, 81–91], aOR 0.5 [95% CI 0.2–1.02]). Conclusion: In contrast to previous studies, the in-hospital mortality rate and functional outcomes during follow-up did not differ between COVID-CVT patients and the pre-COVID-19 controls.

KW - COVID-19

KW - Cerebral venous thrombosis

KW - stroke

UR - https://www.scopus.com/pages/publications/85189608481

U2 - 10.1177/23969873241241885

DO - 10.1177/23969873241241885

M3 - Article

C2 - 38572798

SN - 2396-9873

VL - 9

SP - 676

EP - 686

JO - European Stroke Journal

JF - European Stroke Journal

IS - 3

ER -

Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this