Cellular strategies to cope with protein aggregation

Annika Scior; Katrin Juenemann; Janine Kirstein

doi:10.1042/EBC20160002

Cellular strategies to cope with protein aggregation

Annika Scior
, Katrin Juenemann
, Janine Kirstein^*

^*Corresponding author for this work

Leibniz Institute for Molecular Pharmacology
Amsterdam UMC - University of Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Nature has evolved several mechanisms to detoxify intracellular protein aggregates that arise upon proteotoxic challenges. These include the controlled deposition of misfolded proteins at distinct cellular sites, the protein disaggregation and refolding by molecular chaperones and/or degradation of misfolded and aggregated protein species by cellular clearance pathways. In this article, we discuss cellular the strategies of prokaroytes and eukaryotes to control protein aggregation.

Original language	English
Pages (from-to)	153-161
Journal	Essays in biochemistry
Volume	60
Issue number	2
DOIs	https://doi.org/10.1042/EBC20160002
Publication status	Published - 15 Oct 2016
Externally published	Yes

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title = "Cellular strategies to cope with protein aggregation",

abstract = "Nature has evolved several mechanisms to detoxify intracellular protein aggregates that arise upon proteotoxic challenges. These include the controlled deposition of misfolded proteins at distinct cellular sites, the protein disaggregation and refolding by molecular chaperones and/or degradation of misfolded and aggregated protein species by cellular clearance pathways. In this article, we discuss cellular the strategies of prokaroytes and eukaryotes to control protein aggregation.",

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AB - Nature has evolved several mechanisms to detoxify intracellular protein aggregates that arise upon proteotoxic challenges. These include the controlled deposition of misfolded proteins at distinct cellular sites, the protein disaggregation and refolding by molecular chaperones and/or degradation of misfolded and aggregated protein species by cellular clearance pathways. In this article, we discuss cellular the strategies of prokaroytes and eukaryotes to control protein aggregation.

UR - https://www.scopus.com/pages/publications/85013361001

UR - https://www.ncbi.nlm.nih.gov/pubmed/27744331

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DO - 10.1042/EBC20160002

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EP - 161

JO - Essays in biochemistry

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Cellular strategies to cope with protein aggregation

Abstract

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