Calcium channels in the brain as targets for the calcium-channel modulators used in the treatment of neurological disorders

Th Peters; B. Wilffert; P. M. Vanhoutte; P. A. van Zwieten

doi:10.1097/00005344-199118081-00002

Calcium channels in the brain as targets for the calcium-channel modulators used in the treatment of neurological disorders

Th Peters^*
, B. Wilffert
, P. M. Vanhoutte
, P. A. van Zwieten

^*Corresponding author for this work

Johnson & Johnson
Baylor College of Medicine
University of Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Recent investigations of calcium channels in brain cells by voltage-clamp techniques have revealed that, in spite of electrophysiological similarities, the pharmacological properties of these channels differ considerably from channels in peripheral tissues, e.g., heart and smooth muscle. Therefore, instead of extrapolation from results obtained on cardiac or smooth muscle cells, a reclassification of calcium-channel modulators applied in disorders of the brain appears necessary. The present article reviews some pertinent observations from groups involved in neuronal calcium-channel characterization and draws the attention to major pharmacological differences on neurons in comparison to those in the heart and in smooth muscle. For certain therapeutic applications in neurology particularly, the low-voltage activated types of calcium channels deserve considerable attention. © 1991 Raven Press, Ltd., New York.

Original language	English
Pages (from-to)	S1-S5
Journal	Journal of cardiovascular pharmacology
Volume	18
DOIs	https://doi.org/10.1097/00005344-199118081-00002
Publication status	Published - 1991
Externally published	Yes

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10.1097/00005344-199118081-00002

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title = "Calcium channels in the brain as targets for the calcium-channel modulators used in the treatment of neurological disorders",

abstract = "Recent investigations of calcium channels in brain cells by voltage-clamp techniques have revealed that, in spite of electrophysiological similarities, the pharmacological properties of these channels differ considerably from channels in peripheral tissues, e.g., heart and smooth muscle. Therefore, instead of extrapolation from results obtained on cardiac or smooth muscle cells, a reclassification of calcium-channel modulators applied in disorders of the brain appears necessary. The present article reviews some pertinent observations from groups involved in neuronal calcium-channel characterization and draws the attention to major pharmacological differences on neurons in comparison to those in the heart and in smooth muscle. For certain therapeutic applications in neurology particularly, the low-voltage activated types of calcium channels deserve considerable attention. {\textcopyright} 1991 Raven Press, Ltd., New York.",

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AU - Wilffert, B.

AU - Vanhoutte, P. M.

AU - van Zwieten, P. A.

PY - 1991

Y1 - 1991

N2 - Recent investigations of calcium channels in brain cells by voltage-clamp techniques have revealed that, in spite of electrophysiological similarities, the pharmacological properties of these channels differ considerably from channels in peripheral tissues, e.g., heart and smooth muscle. Therefore, instead of extrapolation from results obtained on cardiac or smooth muscle cells, a reclassification of calcium-channel modulators applied in disorders of the brain appears necessary. The present article reviews some pertinent observations from groups involved in neuronal calcium-channel characterization and draws the attention to major pharmacological differences on neurons in comparison to those in the heart and in smooth muscle. For certain therapeutic applications in neurology particularly, the low-voltage activated types of calcium channels deserve considerable attention. © 1991 Raven Press, Ltd., New York.

AB - Recent investigations of calcium channels in brain cells by voltage-clamp techniques have revealed that, in spite of electrophysiological similarities, the pharmacological properties of these channels differ considerably from channels in peripheral tissues, e.g., heart and smooth muscle. Therefore, instead of extrapolation from results obtained on cardiac or smooth muscle cells, a reclassification of calcium-channel modulators applied in disorders of the brain appears necessary. The present article reviews some pertinent observations from groups involved in neuronal calcium-channel characterization and draws the attention to major pharmacological differences on neurons in comparison to those in the heart and in smooth muscle. For certain therapeutic applications in neurology particularly, the low-voltage activated types of calcium channels deserve considerable attention. © 1991 Raven Press, Ltd., New York.

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VL - 18

SP - S1-S5

JO - Journal of cardiovascular pharmacology

JF - Journal of cardiovascular pharmacology

ER -

Calcium channels in the brain as targets for the calcium-channel modulators used in the treatment of neurological disorders

Abstract

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