Building laboratory capacity to detect and characterize pathogens of public and global health security concern in Kenya

Elizabeth Hunsperger; Bonventure Juma; Clayton Onyango; John B. Ochieng; Victor Omballa; Barry S. Fields; M. Kariuki Njenga; Jane Mwangi; Godfrey Bigogo; Richard Omore; Nancy Otieno; Sandra S. Chaves; Peninah Munyua; Daniel Macharia Njau; Jennifer Verani; Sara Lowther; Robert F. Breiman; Joel M. Montgomery; Kevin M. de Cock; Marc-Alain Widdowson; Evans Apondi; Jeremiah Nyaundi; Lillian Mayieka; Lydia Mwasi; Newton Wamola; Stella Gikunju; Gilbert Kikwai; Caroline Ochieng; Timothy Mujete; Dennis Odhiambo; Melvin Ochieng Ogolla; Everlyne Abisinwa; Robert Mugoh; Herrine Odiembo; Frederick Ade; Jane Juma Onyiengo; Jim Katieno; Patrick Emojong; Shirley Lidechi; Baryl Achieng; Arthur Okloyo; Dorothy Odindo; Wilfrida Agai; Carol Oumo; Lillian Arita; Jairus Abuom; Derrick Amon; Loicer Achieng; Mike Osita; Mose Alando; Josh Mott; Henry Njenga; Linus Ndegwa; Rachael Joseph; Maurice Ope; Charles Okello; Cyrus Wachira; Kabura Wamburu; Lilian Wakhule; Carolyne Jeruto; Solomon Gikundi; Leonard Nderitu; Sylvia Omulo; Rose Wanjala; Joshua Obiya; Patricia Ngotho; Regina Ngore; George Awiti; Wilson Gumbi; Kipyegon Korir; Collins Oungo

doi:10.1186/s12889-019-6770-9

Building laboratory capacity to detect and characterize pathogens of public and global health security concern in Kenya

Elizabeth Hunsperger
, Bonventure Juma
, Clayton Onyango
, John B. Ochieng
, Victor Omballa
, Barry S. Fields
, M. Kariuki Njenga
, Jane Mwangi
, Godfrey Bigogo
, Richard Omore
, Nancy Otieno
, Sandra S. Chaves
, Peninah Munyua
, Daniel Macharia Njau
, Jennifer Verani
, Sara Lowther
, Robert F. Breiman
, Joel M. Montgomery
, Kevin M. de Cock
, Marc-Alain Widdowson

Evans Apondi, Jeremiah Nyaundi, Lillian Mayieka, Lydia Mwasi, Newton Wamola, Stella Gikunju, Gilbert Kikwai, Caroline Ochieng, Timothy Mujete, Dennis Odhiambo, Melvin Ochieng Ogolla, Everlyne Abisinwa, Robert Mugoh, Herrine Odiembo, Frederick Ade, Jane Juma Onyiengo, Jim Katieno, Patrick Emojong, Shirley Lidechi, Baryl Achieng, Arthur Okloyo, Dorothy Odindo, Wilfrida Agai, Carol Oumo, Lillian Arita, Jairus Abuom, Derrick Amon, Loicer Achieng, Mike Osita, Mose Alando, Josh Mott, Henry Njenga, Linus Ndegwa, Rachael Joseph, Maurice Ope, Charles Okello, Cyrus Wachira, Kabura Wamburu, Lilian Wakhule, Carolyne Jeruto, Solomon Gikundi, Leonard Nderitu, Sylvia Omulo, Rose Wanjala, Joshua Obiya, Patricia Ngotho, Regina Ngore, George Awiti, Wilson Gumbi, Kipyegon Korir, Collins Oungo

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Abstract

Since 1979, multiple CDC Kenya programs have supported the development of diagnostic expertise and laboratory capacity in Kenya. In 2004, CDC's Global Disease Detection (GDD) program within the Division of Global Health Protection in Kenya (DGHP-Kenya) initiated close collaboration with Kenya Medical Research Institute (KEMRI) and developed a laboratory partnership called the Diagnostic and Laboratory Systems Program (DLSP). DLSP built onto previous efforts by malaria, human immunodeficiency virus (HIV) and tuberculosis (TB) programs and supported the expansion of the diagnostic expertise and capacity in KEMRI and the Ministry of Health. First, DLSP developed laboratory capacity for surveillance of diarrheal, respiratory, zoonotic and febrile illnesses to understand the etiology burden of these common illnesses and support evidenced-based decisions on vaccine introductions and recommendations in Kenya. Second, we have evaluated and implemented new diagnostic technologies such as TaqMan Array Cards (TAC) to detect emerging or reemerging pathogens and have recently added a next generation sequencer (NGS). Third, DLSP provided rapid laboratory diagnostic support for outbreak investigation to Kenya and regional countries. Fourth, DLSP has been assisting the Kenya National Public Health laboratory-National Influenza Center and microbiology reference laboratory to obtain World Health Organization (WHO) certification and ISO15189 accreditation respectively. Fifth, we have supported biosafety and biosecurity curriculum development to help Kenyan laboratories safely and appropriately manage infectious pathogens. These achievements, highlight how in collaboration with existing CDC programs working on HIV, tuberculosis and malaria, the Global Health Security Agenda can have significantly improve public health in Kenya and the region. Moreover, Kenya provides an example as to how laboratory science can help countries detect and control of infectious disease outbreaks and other public health threats more rapidly, thus enhancing global health security.

Original language	English
Article number	477
Journal	BMC public health
Volume	19
DOIs	https://doi.org/10.1186/s12889-019-6770-9
Publication status	Published - 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Hunsperger, E., Juma, B., Onyango, C., Ochieng, J. B., Omballa, V., Fields, B. S., Njenga, M. K., Mwangi, J., Bigogo, G., Omore, R., Otieno, N., Chaves, S. S., Munyua, P., Njau, D. M., Verani, J., Lowther, S., Breiman, R. F., Montgomery, J. M., de Cock, K. M., ... Oungo, C. (2019). Building laboratory capacity to detect and characterize pathogens of public and global health security concern in Kenya. BMC public health, 19, Article 477. https://doi.org/10.1186/s12889-019-6770-9

@article{3b1045c1afd84b7a87957c7cd335ebd3,

title = "Building laboratory capacity to detect and characterize pathogens of public and global health security concern in Kenya",

abstract = "Since 1979, multiple CDC Kenya programs have supported the development of diagnostic expertise and laboratory capacity in Kenya. In 2004, CDC's Global Disease Detection (GDD) program within the Division of Global Health Protection in Kenya (DGHP-Kenya) initiated close collaboration with Kenya Medical Research Institute (KEMRI) and developed a laboratory partnership called the Diagnostic and Laboratory Systems Program (DLSP). DLSP built onto previous efforts by malaria, human immunodeficiency virus (HIV) and tuberculosis (TB) programs and supported the expansion of the diagnostic expertise and capacity in KEMRI and the Ministry of Health. First, DLSP developed laboratory capacity for surveillance of diarrheal, respiratory, zoonotic and febrile illnesses to understand the etiology burden of these common illnesses and support evidenced-based decisions on vaccine introductions and recommendations in Kenya. Second, we have evaluated and implemented new diagnostic technologies such as TaqMan Array Cards (TAC) to detect emerging or reemerging pathogens and have recently added a next generation sequencer (NGS). Third, DLSP provided rapid laboratory diagnostic support for outbreak investigation to Kenya and regional countries. Fourth, DLSP has been assisting the Kenya National Public Health laboratory-National Influenza Center and microbiology reference laboratory to obtain World Health Organization (WHO) certification and ISO15189 accreditation respectively. Fifth, we have supported biosafety and biosecurity curriculum development to help Kenyan laboratories safely and appropriately manage infectious pathogens. These achievements, highlight how in collaboration with existing CDC programs working on HIV, tuberculosis and malaria, the Global Health Security Agenda can have significantly improve public health in Kenya and the region. Moreover, Kenya provides an example as to how laboratory science can help countries detect and control of infectious disease outbreaks and other public health threats more rapidly, thus enhancing global health security.",

author = "Elizabeth Hunsperger and Bonventure Juma and Clayton Onyango and Ochieng, \{John B.\} and Victor Omballa and Fields, \{Barry S.\} and Njenga, \{M. Kariuki\} and Jane Mwangi and Godfrey Bigogo and Richard Omore and Nancy Otieno and Chaves, \{Sandra S.\} and Peninah Munyua and Njau, \{Daniel Macharia\} and Jennifer Verani and Sara Lowther and Breiman, \{Robert F.\} and Montgomery, \{Joel M.\} and \{de Cock\}, \{Kevin M.\} and Marc-Alain Widdowson and Evans Apondi and Jeremiah Nyaundi and Lillian Mayieka and Lydia Mwasi and Newton Wamola and Stella Gikunju and Gilbert Kikwai and Caroline Ochieng and Timothy Mujete and Dennis Odhiambo and Ogolla, \{Melvin Ochieng\} and Everlyne Abisinwa and Robert Mugoh and Herrine Odiembo and Frederick Ade and Onyiengo, \{Jane Juma\} and Jim Katieno and Patrick Emojong and Shirley Lidechi and Baryl Achieng and Arthur Okloyo and Dorothy Odindo and Wilfrida Agai and Carol Oumo and Lillian Arita and Jairus Abuom and Derrick Amon and Loicer Achieng and Mike Osita and Mose Alando and Josh Mott and Henry Njenga and Linus Ndegwa and Rachael Joseph and Maurice Ope and Charles Okello and Cyrus Wachira and Kabura Wamburu and Lilian Wakhule and Carolyne Jeruto and Solomon Gikundi and Leonard Nderitu and Sylvia Omulo and Rose Wanjala and Joshua Obiya and Patricia Ngotho and Regina Ngore and George Awiti and Wilson Gumbi and Kipyegon Korir and Collins Oungo",

year = "2019",

doi = "10.1186/s12889-019-6770-9",

language = "English",

volume = "19",

journal = "BMC public health",

issn = "1471-2458",

publisher = "BioMed Central",

}

Hunsperger, E, Juma, B, Onyango, C, Ochieng, JB, Omballa, V, Fields, BS, Njenga, MK, Mwangi, J, Bigogo, G, Omore, R, Otieno, N, Chaves, SS, Munyua, P, Njau, DM, Verani, J, Lowther, S, Breiman, RF, Montgomery, JM, de Cock, KM, Widdowson, M-A, Apondi, E, Nyaundi, J, Mayieka, L, Mwasi, L, Wamola, N, Gikunju, S, Kikwai, G, Ochieng, C, Mujete, T, Odhiambo, D, Ogolla, MO, Abisinwa, E, Mugoh, R, Odiembo, H, Ade, F, Onyiengo, JJ, Katieno, J, Emojong, P, Lidechi, S, Achieng, B, Okloyo, A, Odindo, D, Agai, W, Oumo, C, Arita, L, Abuom, J, Amon, D, Achieng, L, Osita, M, Alando, M, Mott, J, Njenga, H, Ndegwa, L, Joseph, R, Ope, M, Okello, C, Wachira, C, Wamburu, K, Wakhule, L, Jeruto, C, Gikundi, S, Nderitu, L, Omulo, S, Wanjala, R, Obiya, J, Ngotho, P, Ngore, R, Awiti, G, Gumbi, W, Korir, K & Oungo, C 2019, 'Building laboratory capacity to detect and characterize pathogens of public and global health security concern in Kenya', BMC public health, vol. 19, 477. https://doi.org/10.1186/s12889-019-6770-9

TY - JOUR

T1 - Building laboratory capacity to detect and characterize pathogens of public and global health security concern in Kenya

AU - Hunsperger, Elizabeth

AU - Juma, Bonventure

AU - Onyango, Clayton

AU - Ochieng, John B.

AU - Omballa, Victor

AU - Fields, Barry S.

AU - Njenga, M. Kariuki

AU - Mwangi, Jane

AU - Bigogo, Godfrey

AU - Omore, Richard

AU - Otieno, Nancy

AU - Chaves, Sandra S.

AU - Munyua, Peninah

AU - Njau, Daniel Macharia

AU - Verani, Jennifer

AU - Lowther, Sara

AU - Breiman, Robert F.

AU - Montgomery, Joel M.

AU - de Cock, Kevin M.

AU - Widdowson, Marc-Alain

AU - Apondi, Evans

AU - Nyaundi, Jeremiah

AU - Mayieka, Lillian

AU - Mwasi, Lydia

AU - Wamola, Newton

AU - Gikunju, Stella

AU - Kikwai, Gilbert

AU - Ochieng, Caroline

AU - Mujete, Timothy

AU - Odhiambo, Dennis

AU - Ogolla, Melvin Ochieng

AU - Abisinwa, Everlyne

AU - Mugoh, Robert

AU - Odiembo, Herrine

AU - Ade, Frederick

AU - Onyiengo, Jane Juma

AU - Katieno, Jim

AU - Emojong, Patrick

AU - Lidechi, Shirley

AU - Achieng, Baryl

AU - Okloyo, Arthur

AU - Odindo, Dorothy

AU - Agai, Wilfrida

AU - Oumo, Carol

AU - Arita, Lillian

AU - Abuom, Jairus

AU - Amon, Derrick

AU - Achieng, Loicer

AU - Osita, Mike

AU - Alando, Mose

AU - Mott, Josh

AU - Njenga, Henry

AU - Ndegwa, Linus

AU - Joseph, Rachael

AU - Ope, Maurice

AU - Okello, Charles

AU - Wachira, Cyrus

AU - Wamburu, Kabura

AU - Wakhule, Lilian

AU - Jeruto, Carolyne

AU - Gikundi, Solomon

AU - Nderitu, Leonard

AU - Omulo, Sylvia

AU - Wanjala, Rose

AU - Obiya, Joshua

AU - Ngotho, Patricia

AU - Ngore, Regina

AU - Awiti, George

AU - Gumbi, Wilson

AU - Korir, Kipyegon

AU - Oungo, Collins

PY - 2019

Y1 - 2019

N2 - Since 1979, multiple CDC Kenya programs have supported the development of diagnostic expertise and laboratory capacity in Kenya. In 2004, CDC's Global Disease Detection (GDD) program within the Division of Global Health Protection in Kenya (DGHP-Kenya) initiated close collaboration with Kenya Medical Research Institute (KEMRI) and developed a laboratory partnership called the Diagnostic and Laboratory Systems Program (DLSP). DLSP built onto previous efforts by malaria, human immunodeficiency virus (HIV) and tuberculosis (TB) programs and supported the expansion of the diagnostic expertise and capacity in KEMRI and the Ministry of Health. First, DLSP developed laboratory capacity for surveillance of diarrheal, respiratory, zoonotic and febrile illnesses to understand the etiology burden of these common illnesses and support evidenced-based decisions on vaccine introductions and recommendations in Kenya. Second, we have evaluated and implemented new diagnostic technologies such as TaqMan Array Cards (TAC) to detect emerging or reemerging pathogens and have recently added a next generation sequencer (NGS). Third, DLSP provided rapid laboratory diagnostic support for outbreak investigation to Kenya and regional countries. Fourth, DLSP has been assisting the Kenya National Public Health laboratory-National Influenza Center and microbiology reference laboratory to obtain World Health Organization (WHO) certification and ISO15189 accreditation respectively. Fifth, we have supported biosafety and biosecurity curriculum development to help Kenyan laboratories safely and appropriately manage infectious pathogens. These achievements, highlight how in collaboration with existing CDC programs working on HIV, tuberculosis and malaria, the Global Health Security Agenda can have significantly improve public health in Kenya and the region. Moreover, Kenya provides an example as to how laboratory science can help countries detect and control of infectious disease outbreaks and other public health threats more rapidly, thus enhancing global health security.

AB - Since 1979, multiple CDC Kenya programs have supported the development of diagnostic expertise and laboratory capacity in Kenya. In 2004, CDC's Global Disease Detection (GDD) program within the Division of Global Health Protection in Kenya (DGHP-Kenya) initiated close collaboration with Kenya Medical Research Institute (KEMRI) and developed a laboratory partnership called the Diagnostic and Laboratory Systems Program (DLSP). DLSP built onto previous efforts by malaria, human immunodeficiency virus (HIV) and tuberculosis (TB) programs and supported the expansion of the diagnostic expertise and capacity in KEMRI and the Ministry of Health. First, DLSP developed laboratory capacity for surveillance of diarrheal, respiratory, zoonotic and febrile illnesses to understand the etiology burden of these common illnesses and support evidenced-based decisions on vaccine introductions and recommendations in Kenya. Second, we have evaluated and implemented new diagnostic technologies such as TaqMan Array Cards (TAC) to detect emerging or reemerging pathogens and have recently added a next generation sequencer (NGS). Third, DLSP provided rapid laboratory diagnostic support for outbreak investigation to Kenya and regional countries. Fourth, DLSP has been assisting the Kenya National Public Health laboratory-National Influenza Center and microbiology reference laboratory to obtain World Health Organization (WHO) certification and ISO15189 accreditation respectively. Fifth, we have supported biosafety and biosecurity curriculum development to help Kenyan laboratories safely and appropriately manage infectious pathogens. These achievements, highlight how in collaboration with existing CDC programs working on HIV, tuberculosis and malaria, the Global Health Security Agenda can have significantly improve public health in Kenya and the region. Moreover, Kenya provides an example as to how laboratory science can help countries detect and control of infectious disease outbreaks and other public health threats more rapidly, thus enhancing global health security.

UR - https://www.scopus.com/pages/publications/85065622419

U2 - 10.1186/s12889-019-6770-9

DO - 10.1186/s12889-019-6770-9

M3 - Article

C2 - 32326916

SN - 1471-2458

VL - 19

JO - BMC public health

JF - BMC public health

M1 - 477

ER -

Building laboratory capacity to detect and characterize pathogens of public and global health security concern in Kenya

Abstract

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