Brain and body energy metabolism and potential for treatment of psychiatric disorders

Ana C. Andreazza; L. Felipe Barros; Alexander Behnke; Dorit Ben-Shachar; Sabina Berretta; Virginie-Anne Chouinard; Kim Do; Sharmili Edwin Thanarajah; Hannelore Ehrenreich; Peter Falkai; Judith Ford; Zachary Freyberg; Javier Gilbert-Jaramillo; Jill R. Glausier; Manu S. Goyal; Margaret Hahn; Suzana Herculano-Houzel; David Hofmann; Iris-Tatjana Kolassa; Matthias Mack; R. Nehir Mavioglu; Robert McCullumsmith; Yuri Milaneschi; Anthony J. A. Molina; Lilianne Mujica-Parodi; Dost Öngür; Martin Paulus; Daria Peleg-Raibstein; Ben Perry; Martin Picard; Toby Pillinger; Caroline Rae; Douglas Rothman; Zoltan Sarnyai; Johann Steiner; Rachel Upthegrove; Anthony C. Vernon; Melanie Wall; Corey Weistuch

doi:10.1038/s44220-025-00422-6

Brain and body energy metabolism and potential for treatment of psychiatric disorders

Ana C. Andreazza
, L. Felipe Barros
, Alexander Behnke
, Dorit Ben-Shachar
, Sabina Berretta
, Virginie-Anne Chouinard
, Kim Do
, Sharmili Edwin Thanarajah
, Hannelore Ehrenreich
, Peter Falkai
, Judith Ford
, Zachary Freyberg
, Javier Gilbert-Jaramillo
, Jill R. Glausier
, Manu S. Goyal
, Margaret Hahn
, Suzana Herculano-Houzel
, David Hofmann
, Iris-Tatjana Kolassa
, Matthias Mack

R. Nehir Mavioglu, Robert McCullumsmith, Yuri Milaneschi, Anthony J. A. Molina, Lilianne Mujica-Parodi, Dost Öngür^*, Martin Paulus, Daria Peleg-Raibstein, Ben Perry, Martin Picard, Toby Pillinger, Caroline Rae, Douglas Rothman, Zoltan Sarnyai, Johann Steiner, Rachel Upthegrove, Anthony C. Vernon, Melanie Wall, Corey Weistuch

^*Corresponding author for this work

University of Toronto
Centro de Estudios Científicos
Ulm University
Technion-Israel Institute of Technology
Harvard University
University of Lausanne
Goethe University Frankfurt
Max Planck Institute of Experimental Medicine
Ludwig Maximilian University of Munich
University of California at San Francisco
University of Pittsburgh
University of Oxford
Washington University St. Louis
Institute for Mental Health Policy Research
Vanderbilt University
Massachusetts Institute of Technology
University of Toledo
Vrije Universiteit Amsterdam
University of California at San Diego
Stony Brook University
Laureate Institute for Brain Research
Swiss Federal Institute of Technology Zurich
University of Cambridge
Columbia University
King's College London
Neuroscience Research Australia
Yale University
James Cook University Queensland
Otto von Guericke University Magdeburg
Memorial Sloan-Kettering Cancer Center

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

Brain function is critically dependent on energy metabolism. Research over the past half century has provided many insights into energy production and utilization in the brain, and identified ways that it can be improved in brain disorders. A parallel literature indicates that major aberrations exist in brain bioenergetics in neuropsychiatric disorders. Targeting bioenergetic abnormalities may be an efficacious approach to treatment for these conditions. In this Perspective, we provide a survey of the relevant literature on these topics and sketch the outlines of a research agenda to maximize the impact of future research and treatment interventions.

Original language	English
Pages (from-to)	763-771
Number of pages	9
Journal	Nat. mental health
Volume	3
Issue number	7
DOIs	https://doi.org/10.1038/s44220-025-00422-6
Publication status	Published - 1 Jul 2025

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Andreazza, A. C., Barros, L. F., Behnke, A., Ben-Shachar, D., Berretta, S., Chouinard, V.-A., Do, K., Edwin Thanarajah, S., Ehrenreich, H., Falkai, P., Ford, J., Freyberg, Z., Gilbert-Jaramillo, J., Glausier, J. R., Goyal, M. S., Hahn, M., Herculano-Houzel, S., Hofmann, D., Kolassa, I.-T., ... Weistuch, C. (2025). Brain and body energy metabolism and potential for treatment of psychiatric disorders. Nat. mental health, 3(7), 763-771. https://doi.org/10.1038/s44220-025-00422-6

@article{71b7f2ec1fa14d328275b19db3d6b435,

title = "Brain and body energy metabolism and potential for treatment of psychiatric disorders",

abstract = "Brain function is critically dependent on energy metabolism. Research over the past half century has provided many insights into energy production and utilization in the brain, and identified ways that it can be improved in brain disorders. A parallel literature indicates that major aberrations exist in brain bioenergetics in neuropsychiatric disorders. Targeting bioenergetic abnormalities may be an efficacious approach to treatment for these conditions. In this Perspective, we provide a survey of the relevant literature on these topics and sketch the outlines of a research agenda to maximize the impact of future research and treatment interventions.",

author = "Andreazza, \{Ana C.\} and Barros, \{L. Felipe\} and Alexander Behnke and Dorit Ben-Shachar and Sabina Berretta and Virginie-Anne Chouinard and Kim Do and \{Edwin Thanarajah\}, Sharmili and Hannelore Ehrenreich and Peter Falkai and Judith Ford and Zachary Freyberg and Javier Gilbert-Jaramillo and Glausier, \{Jill R.\} and Goyal, \{Manu S.\} and Margaret Hahn and Suzana Herculano-Houzel and David Hofmann and Iris-Tatjana Kolassa and Matthias Mack and Mavioglu, \{R. Nehir\} and Robert McCullumsmith and Yuri Milaneschi and Molina, \{Anthony J. A.\} and Lilianne Mujica-Parodi and Dost {\"O}ng{\"u}r and Martin Paulus and Daria Peleg-Raibstein and Ben Perry and Martin Picard and Toby Pillinger and Caroline Rae and Douglas Rothman and Zoltan Sarnyai and Johann Steiner and Rachel Upthegrove and Vernon, \{Anthony C.\} and Melanie Wall and Corey Weistuch",

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year = "2025",

month = jul,

day = "1",

doi = "10.1038/s44220-025-00422-6",

language = "English",

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Andreazza, AC, Barros, LF, Behnke, A, Ben-Shachar, D, Berretta, S, Chouinard, V-A, Do, K, Edwin Thanarajah, S, Ehrenreich, H, Falkai, P, Ford, J, Freyberg, Z, Gilbert-Jaramillo, J, Glausier, JR, Goyal, MS, Hahn, M, Herculano-Houzel, S, Hofmann, D, Kolassa, I-T, Mack, M, Mavioglu, RN, McCullumsmith, R, Milaneschi, Y, Molina, AJA, Mujica-Parodi, L, Öngür, D, Paulus, M, Peleg-Raibstein, D, Perry, B, Picard, M, Pillinger, T, Rae, C, Rothman, D, Sarnyai, Z, Steiner, J, Upthegrove, R, Vernon, AC, Wall, M & Weistuch, C 2025, 'Brain and body energy metabolism and potential for treatment of psychiatric disorders', Nat. mental health, vol. 3, no. 7, pp. 763-771. https://doi.org/10.1038/s44220-025-00422-6

TY - JOUR

T1 - Brain and body energy metabolism and potential for treatment of psychiatric disorders

AU - Andreazza, Ana C.

AU - Barros, L. Felipe

AU - Behnke, Alexander

AU - Ben-Shachar, Dorit

AU - Berretta, Sabina

AU - Chouinard, Virginie-Anne

AU - Do, Kim

AU - Edwin Thanarajah, Sharmili

AU - Ehrenreich, Hannelore

AU - Falkai, Peter

AU - Ford, Judith

AU - Freyberg, Zachary

AU - Gilbert-Jaramillo, Javier

AU - Glausier, Jill R.

AU - Goyal, Manu S.

AU - Hahn, Margaret

AU - Herculano-Houzel, Suzana

AU - Hofmann, David

AU - Kolassa, Iris-Tatjana

AU - Mack, Matthias

AU - Mavioglu, R. Nehir

AU - McCullumsmith, Robert

AU - Milaneschi, Yuri

AU - Molina, Anthony J. A.

AU - Mujica-Parodi, Lilianne

AU - Öngür, Dost

AU - Paulus, Martin

AU - Peleg-Raibstein, Daria

AU - Perry, Ben

AU - Picard, Martin

AU - Pillinger, Toby

AU - Rae, Caroline

AU - Rothman, Douglas

AU - Sarnyai, Zoltan

AU - Steiner, Johann

AU - Upthegrove, Rachel

AU - Vernon, Anthony C.

AU - Wall, Melanie

AU - Weistuch, Corey

PY - 2025/7/1

Y1 - 2025/7/1

N2 - Brain function is critically dependent on energy metabolism. Research over the past half century has provided many insights into energy production and utilization in the brain, and identified ways that it can be improved in brain disorders. A parallel literature indicates that major aberrations exist in brain bioenergetics in neuropsychiatric disorders. Targeting bioenergetic abnormalities may be an efficacious approach to treatment for these conditions. In this Perspective, we provide a survey of the relevant literature on these topics and sketch the outlines of a research agenda to maximize the impact of future research and treatment interventions.

AB - Brain function is critically dependent on energy metabolism. Research over the past half century has provided many insights into energy production and utilization in the brain, and identified ways that it can be improved in brain disorders. A parallel literature indicates that major aberrations exist in brain bioenergetics in neuropsychiatric disorders. Targeting bioenergetic abnormalities may be an efficacious approach to treatment for these conditions. In this Perspective, we provide a survey of the relevant literature on these topics and sketch the outlines of a research agenda to maximize the impact of future research and treatment interventions.

UR - https://www.scopus.com/pages/publications/105011820843

U2 - 10.1038/s44220-025-00422-6

DO - 10.1038/s44220-025-00422-6

M3 - Review article

SN - 2731-6076

VL - 3

SP - 763

EP - 771

JO - Nat. mental health

JF - Nat. mental health

IS - 7

ER -

Brain and body energy metabolism and potential for treatment of psychiatric disorders

Abstract

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