BMI predicts exercise induced bronchoconstriction in asthmatic boys

BackgroundExercise induced bronchoconstriction (EIB) is a frustrating morbidity of asthma in children. Obesity has been associated with asthma and with more severe EIB in asthmatic children. ObjectivesTo quantify the effect of BMI on the risk of the occurrence of EIB in children with asthma. MethodsData were collected from six studies in which exercise challenge tests were performed according to international guidelines. We included 212 Children aged 7-18 years, with a pediatrician-diagnosed mild-to-moderate asthma. ResultsA total of 103 of 212 children (49%) had a positive exercise challenge (fall of FEV(1)13%). The severity of EIB, as measured by the maximum fall in FEV1, was significantly greater in overweight and obese children compared to normal weight children (respectively 23.9% vs 17.9%; P=0.045). Asthmatic children with a BMI z-score around +1 had a 2.9-fold higher risk of the prevalence of EIB compared to children with a BMI z-score around the mean (OR 2.9; 95%CI: 1.3-6.1; P <0.01). An increase in BMI z-score of 0.1 in boys led to a 1.4-fold increased risk of EIB (OR 1.4; 95%CI: 1.0-1.9; P=0.03). A reduction in pre-exercise FEV1 was associated with a higher risk of EIB (last quartile six times higher risk compared to highest quartile (OR 6.1 [95%CI 2.5-14.5]). ConclusionsThe severity of EIB is significantly greater in children with overweight and obesity compared to non-overweight asthmatic children. Furthermore, this study shows that the BMI-z-score, even with a normal weight, is strongly associated with the incidence of EIB in asthmatic boys