Biogenesis and function of extracellular vesicles in cancer

Maarten P. Bebelman; Martine J. Smit; D. Michiel Pegtel; S. Rubina Baglio

doi:10.1016/j.pharmthera.2018.02.013

Biogenesis and function of extracellular vesicles in cancer

Maarten P. Bebelman
, Martine J. Smit
, D. Michiel Pegtel
, S. Rubina Baglio^*

^*Corresponding author for this work

Amsterdam UMC
Vrije Universiteit Amsterdam
Department of Pathology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands; Division of Medicinal Chemistry, Amsterdam Institute for Molecules Medicines and Systems, VU University, Amsterdam, The Netherlands.
Division of Medicinal Chemistry, Amsterdam Institute for Molecules Medicines and Systems, VU University, Amsterdam, The Netherlands.

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Extracellular vesicles (EVs) are heterogeneous multi-signal messengers that support cancer growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes are a subtype of EVs that originate from the limiting membrane of late endosomes, and as such contain information linked to both the intrinsic cell “state” and the extracellular signals cells received from their environment. Resolving the signals affecting exosome biogenesis, cargo sorting and release will increase our understanding of tumorigenesis. In this review we highlight key cell biological processes that couple exosome biogenesis to cargo sorting in cancer cells. Moreover, we discuss how the bidirectional communication between tumor and non-malignant cells affect cancer growth and metastatic behavior.

Original language	English
Pages (from-to)	1-11
Number of pages	11
Journal	Pharmacology & therapeutics
Volume	188
Early online date	21 Feb 2018
DOIs	https://doi.org/10.1016/j.pharmthera.2018.02.013
Publication status	Published - 1 Aug 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cargo sorting
Exosome biogenesis
Extracellular vesicles
Tumor microenvironment
Tumor-stroma communication

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10.1016/j.pharmthera.2018.02.013

Cite this

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title = "Biogenesis and function of extracellular vesicles in cancer",

abstract = "Extracellular vesicles (EVs) are heterogeneous multi-signal messengers that support cancer growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes are a subtype of EVs that originate from the limiting membrane of late endosomes, and as such contain information linked to both the intrinsic cell “state” and the extracellular signals cells received from their environment. Resolving the signals affecting exosome biogenesis, cargo sorting and release will increase our understanding of tumorigenesis. In this review we highlight key cell biological processes that couple exosome biogenesis to cargo sorting in cancer cells. Moreover, we discuss how the bidirectional communication between tumor and non-malignant cells affect cancer growth and metastatic behavior.",

keywords = "Cargo sorting, Exosome biogenesis, Extracellular vesicles, Tumor microenvironment, Tumor-stroma communication",

author = "Bebelman, \{Maarten P.\} and Smit, \{Martine J.\} and Pegtel, \{D. Michiel\} and Baglio, \{S. Rubina\}",

year = "2018",

month = aug,

day = "1",

doi = "10.1016/j.pharmthera.2018.02.013",

language = "English",

volume = "188",

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journal = "Pharmacology \& therapeutics",

issn = "0163-7258",

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TY - JOUR

T1 - Biogenesis and function of extracellular vesicles in cancer

AU - Bebelman, Maarten P.

AU - Smit, Martine J.

AU - Pegtel, D. Michiel

AU - Baglio, S. Rubina

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Extracellular vesicles (EVs) are heterogeneous multi-signal messengers that support cancer growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes are a subtype of EVs that originate from the limiting membrane of late endosomes, and as such contain information linked to both the intrinsic cell “state” and the extracellular signals cells received from their environment. Resolving the signals affecting exosome biogenesis, cargo sorting and release will increase our understanding of tumorigenesis. In this review we highlight key cell biological processes that couple exosome biogenesis to cargo sorting in cancer cells. Moreover, we discuss how the bidirectional communication between tumor and non-malignant cells affect cancer growth and metastatic behavior.

AB - Extracellular vesicles (EVs) are heterogeneous multi-signal messengers that support cancer growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes are a subtype of EVs that originate from the limiting membrane of late endosomes, and as such contain information linked to both the intrinsic cell “state” and the extracellular signals cells received from their environment. Resolving the signals affecting exosome biogenesis, cargo sorting and release will increase our understanding of tumorigenesis. In this review we highlight key cell biological processes that couple exosome biogenesis to cargo sorting in cancer cells. Moreover, we discuss how the bidirectional communication between tumor and non-malignant cells affect cancer growth and metastatic behavior.

KW - Cargo sorting

KW - Exosome biogenesis

KW - Extracellular vesicles

KW - Tumor microenvironment

KW - Tumor-stroma communication

UR - https://www.scopus.com/pages/publications/85042858674

UR - https://www.ncbi.nlm.nih.gov/pubmed/29476772

UR - http://www.mendeley.com/research/biogenesis-function-extracellular-vesicles-cancer

U2 - 10.1016/j.pharmthera.2018.02.013

DO - 10.1016/j.pharmthera.2018.02.013

M3 - Review article

C2 - 29476772

SN - 0163-7258

VL - 188

SP - 1

EP - 11

JO - Pharmacology & therapeutics

JF - Pharmacology & therapeutics

ER -

Biogenesis and function of extracellular vesicles in cancer

Abstract

UN SDGs

Keywords

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