B cells and their signaling pathways: The guiding lights to decipher and target autoimmunity

Autoimmunity arises when the immune system misrecognizes self as non-self, leading to chronic inflammation and tissue damage. B cells are central to this process by producing autoantibodies, presenting self-antigens, and secreting pro-inflammatory mediators. This thesis focuses on B cell biology in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), idiopathic