B-cell antigen receptor-induced apoptosis: looking for clues

Eric Eldering; René A. W. VanLier

doi:10.1016/j.imlet.2004.09.003

B-cell antigen receptor-induced apoptosis: looking for clues

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Triggering of the B cell antigen receptor (BCR) can initiate divergent responses ranging from activation and cell division to apoptosis, depending on the differentiation stage and additional signals the cell receives. Despite considerable progress in unraveling general apoptosis pathways, the route from the BCR to apoptosis execution is still quite obscure, and there is no consensus yet concerning the mechanism or the players involved. Here, we will summarize current developments in this field and will attempt to pinpoint key questions and perspectives for future research

Original language	English
Pages (from-to)	187-194
Journal	Immunology letters
Volume	96
Issue number	2
DOIs	https://doi.org/10.1016/j.imlet.2004.09.003
Publication status	Published - 2005

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title = "B-cell antigen receptor-induced apoptosis: looking for clues",

abstract = "Triggering of the B cell antigen receptor (BCR) can initiate divergent responses ranging from activation and cell division to apoptosis, depending on the differentiation stage and additional signals the cell receives. Despite considerable progress in unraveling general apoptosis pathways, the route from the BCR to apoptosis execution is still quite obscure, and there is no consensus yet concerning the mechanism or the players involved. Here, we will summarize current developments in this field and will attempt to pinpoint key questions and perspectives for future research",

author = "Eric Eldering and VanLier, \{Ren{\'e} A. W.\}",

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doi = "10.1016/j.imlet.2004.09.003",

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AU - Eldering, Eric

AU - VanLier, René A. W.

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N2 - Triggering of the B cell antigen receptor (BCR) can initiate divergent responses ranging from activation and cell division to apoptosis, depending on the differentiation stage and additional signals the cell receives. Despite considerable progress in unraveling general apoptosis pathways, the route from the BCR to apoptosis execution is still quite obscure, and there is no consensus yet concerning the mechanism or the players involved. Here, we will summarize current developments in this field and will attempt to pinpoint key questions and perspectives for future research

AB - Triggering of the B cell antigen receptor (BCR) can initiate divergent responses ranging from activation and cell division to apoptosis, depending on the differentiation stage and additional signals the cell receives. Despite considerable progress in unraveling general apoptosis pathways, the route from the BCR to apoptosis execution is still quite obscure, and there is no consensus yet concerning the mechanism or the players involved. Here, we will summarize current developments in this field and will attempt to pinpoint key questions and perspectives for future research

U2 - 10.1016/j.imlet.2004.09.003

DO - 10.1016/j.imlet.2004.09.003

M3 - Review article

C2 - 15585322

SN - 0165-2478

VL - 96

SP - 187

EP - 194

JO - Immunology letters

JF - Immunology letters

IS - 2

ER -

B-cell antigen receptor-induced apoptosis: looking for clues

Abstract

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