At What Age Could Screening for Familial Retinoblastoma Be Discontinued?: A Systematic Review

Milo van Hoefen Wijsard; Saskia H Serné; René H Otten; Machteld I Bosscha; Charlotte J Dommering; Armida W Fabius; Annette C Moll

doi:10.3390/cancers13081942

At What Age Could Screening for Familial Retinoblastoma Be Discontinued? A Systematic Review

From the Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands (A.H.R., L.G.P.H.V., B.G., R.S.P., S.N., J.J.J.d.V., H.J.S., M.R.M.); Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, the Netherlands (E.v.V., M.G.B.); Department of Surgery, Cancer Center Amsterdam...
Medical library, VU University Medical Center, Amsterdam, The Netherlands.

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Abstract

The aim of this systematic review is to assess the latest age at diagnosis for detection of familial retinoblastoma in order to evaluate at what age screening of at-risk children could be discontinued. Extended screening beyond this age would result in unnecessary patient burden and costs. However, discontinuing screening prematurely would have the adverse effect of missing tumors. We performed a literature search (PubMed, Embase, CINAHL and the Cochrane Library) up until February of 2021 and systematically included studies where patients had a family history of retinoblastoma, a known age at diagnosis, and who were ophthalmologically screened for retinoblastoma from birth. A total of 176 familial retinoblastoma patients from 17 studies were included in this review. Based on 48 months of age being the latest age of diagnosis, ophthalmological screening for familial retinoblastoma could safely be discontinued at age four years.

Original language	English
Article number	1942
Journal	Cancers
Volume	13
Issue number	8
DOIs	https://doi.org/10.3390/cancers13081942
Publication status	Published - 2 Apr 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Age at diagnosis
Familial retinoblastoma
Screening

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Cite this

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title = "At What Age Could Screening for Familial Retinoblastoma Be Discontinued?: A Systematic Review",

abstract = "The aim of this systematic review is to assess the latest age at diagnosis for detection of familial retinoblastoma in order to evaluate at what age screening of at-risk children could be discontinued. Extended screening beyond this age would result in unnecessary patient burden and costs. However, discontinuing screening prematurely would have the adverse effect of missing tumors. We performed a literature search (PubMed, Embase, CINAHL and the Cochrane Library) up until February of 2021 and systematically included studies where patients had a family history of retinoblastoma, a known age at diagnosis, and who were ophthalmologically screened for retinoblastoma from birth. A total of 176 familial retinoblastoma patients from 17 studies were included in this review. Based on 48 months of age being the latest age of diagnosis, ophthalmological screening for familial retinoblastoma could safely be discontinued at age four years.",

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T1 - At What Age Could Screening for Familial Retinoblastoma Be Discontinued?

T2 - A Systematic Review

AU - van Hoefen Wijsard, Milo

AU - Serné, Saskia H

AU - Otten, René H

AU - Bosscha, Machteld I

AU - Dommering, Charlotte J

AU - Fabius, Armida W

AU - Moll, Annette C

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AB - The aim of this systematic review is to assess the latest age at diagnosis for detection of familial retinoblastoma in order to evaluate at what age screening of at-risk children could be discontinued. Extended screening beyond this age would result in unnecessary patient burden and costs. However, discontinuing screening prematurely would have the adverse effect of missing tumors. We performed a literature search (PubMed, Embase, CINAHL and the Cochrane Library) up until February of 2021 and systematically included studies where patients had a family history of retinoblastoma, a known age at diagnosis, and who were ophthalmologically screened for retinoblastoma from birth. A total of 176 familial retinoblastoma patients from 17 studies were included in this review. Based on 48 months of age being the latest age of diagnosis, ophthalmological screening for familial retinoblastoma could safely be discontinued at age four years.

KW - Age at diagnosis

KW - Familial retinoblastoma

KW - Screening

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