TY - JOUR
T1 - Associations between blood biomarkers, cardiac function and adverse outcome in a young tetralogy of Fallot cohort
AU - van den Bosch, Eva
AU - van Genuchten, Wouter J.
AU - Luijnenburg, Saskia E.
AU - Duppen, Nienke
AU - Kamphuis, Vivian P.
AU - Roos-Hesselink, Jolien W.
AU - Bartelds, Beatrijs
AU - Roest, Arno A. W.
AU - Breur, Johannes M. P. J.
AU - Blom, Nico A.
AU - Boersma, Eric
AU - Koopman, Laurens P.
AU - Helbing, Willem A.
N1 - Funding Information:
E. van den Bosch, W.J. van Genuchten, V.P. Kamphuis, J.W. Roos-Hesselink, N. Duppen and S. E. Luijnenburg were supported by research grants from the Dutch Heart Foundation (grant 2013T091 , grant 2013T093 , grant 2008B026 and grant 2006B095 ).
Publisher Copyright:
© 2022 The Authors
PY - 2022/8/15
Y1 - 2022/8/15
N2 - Background: To determine the potential prognostic value and clinical correlations of blood biomarkers in a cohort of patients with Tetralogy of Fallot (TOF). Methods: In the setting of multicenter prospective research studies TOF patients underwent blood sampling, cardiopulmonary exercise testing and low-dose dobutamine stress cardiac magnetic resonance (CMR) imaging. In the blood sample NT-proBNP, GDF-15, Galectin-3, ST-2, DLK-1, FABP4, IGFBP-1, IGFBP-7, MMP-2, and vWF were assessed. During subsequent follow-up, patients were evaluated for reaching the study endpoint (cardiac death, arrhythmia-related hospitalization or cardioversion/ablation, VO2 max ≤65% of predicted). Regression analysis was used to explore the correlation between blood biomarkers (corrected for age and gender) and other clinical parameters. The potential predictive value of blood biomarkers and events were assessed with Kaplan-Meier analysis and Cox proportional hazard analysis. Results: We included 137 Fallot patients, median age 19.2 (interquartile range: 14.6–25.7) years, median age at TOF-repair 0.9 (0.5–1.9) years. After a median follow-up of 8.7 (6.3–10.7) years, 20 (14.6%) patients reached the composite endpoint. In a multivariable cox-regression analysis corrected for age at study baseline, elevated IGFBP-7 and MMP-2 levels were associated with the composite endpoint. We also noted a correlation between DLK-1 and relative change in right ventricular end systolic volume during dobutamine stress CMR (β = −0.27, p = 0.010), a correlation between FABP4 and Max VO2 (β = −0.41, p ≤0.001 and between MMP-2 and tricuspid valve E/A ratio (β = −0.15, p = 0.037). Conclusions: IGFBP-7, MMP-2 and DLK-1 levels are related to cardiac function and long-term outcome in TOF patients.
AB - Background: To determine the potential prognostic value and clinical correlations of blood biomarkers in a cohort of patients with Tetralogy of Fallot (TOF). Methods: In the setting of multicenter prospective research studies TOF patients underwent blood sampling, cardiopulmonary exercise testing and low-dose dobutamine stress cardiac magnetic resonance (CMR) imaging. In the blood sample NT-proBNP, GDF-15, Galectin-3, ST-2, DLK-1, FABP4, IGFBP-1, IGFBP-7, MMP-2, and vWF were assessed. During subsequent follow-up, patients were evaluated for reaching the study endpoint (cardiac death, arrhythmia-related hospitalization or cardioversion/ablation, VO2 max ≤65% of predicted). Regression analysis was used to explore the correlation between blood biomarkers (corrected for age and gender) and other clinical parameters. The potential predictive value of blood biomarkers and events were assessed with Kaplan-Meier analysis and Cox proportional hazard analysis. Results: We included 137 Fallot patients, median age 19.2 (interquartile range: 14.6–25.7) years, median age at TOF-repair 0.9 (0.5–1.9) years. After a median follow-up of 8.7 (6.3–10.7) years, 20 (14.6%) patients reached the composite endpoint. In a multivariable cox-regression analysis corrected for age at study baseline, elevated IGFBP-7 and MMP-2 levels were associated with the composite endpoint. We also noted a correlation between DLK-1 and relative change in right ventricular end systolic volume during dobutamine stress CMR (β = −0.27, p = 0.010), a correlation between FABP4 and Max VO2 (β = −0.41, p ≤0.001 and between MMP-2 and tricuspid valve E/A ratio (β = −0.15, p = 0.037). Conclusions: IGFBP-7, MMP-2 and DLK-1 levels are related to cardiac function and long-term outcome in TOF patients.
KW - DLK-1
KW - IGFPB-7
KW - MMP-2
KW - NT-proBNP
KW - Outcome
KW - Tetralogy of Fallot
UR - https://www.scopus.com/pages/publications/85129477429
U2 - 10.1016/j.ijcard.2022.04.065
DO - 10.1016/j.ijcard.2022.04.065
M3 - Article
C2 - 35487320
SN - 0167-5273
VL - 361
SP - 31
EP - 37
JO - International journal of cardiology
JF - International journal of cardiology
ER -