TY - JOUR
T1 - Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting
AU - Slof-Op 't Landt, M. C. T.
AU - Meulenbelt, I.
AU - Bartels, M.
AU - Suchiman, E.
AU - Middeldorp, C. M.
AU - Houwing-Duistermaat, J. J.
AU - van Trier, J.
AU - Onkenhout, E. J.
AU - Vink, J. M.
AU - van Beijsterveldt, C. E. M.
AU - Brandys, M. K.
AU - Sanders, N.
AU - Zipfel, S.
AU - Herzog, W.
AU - Herpertz-Dahlmann, B.
AU - Klampfl, K.
AU - Fleischhaker, C.
AU - Zeeck, A.
AU - de Zwaan, M.
AU - Herpertz, S.
AU - Ehrlich, S.
AU - van Elburg, A. A.
AU - Adan, R. A. H.
AU - Scherag, S.
AU - Hinney, A.
AU - Hebebrand, J.
AU - Boomsma, D. I.
AU - van Furth, E. F.
AU - Slagboom, P. E.
PY - 2011
Y1 - 2011
N2 - Twin studies suggest that genetic factors play a substantial role in anorexia nervosa (AN) and self-induced vomiting (SV), a key symptom that is shared among different types of eating disorders (EDs). We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of the common variance in candidate genes, stathmin (STMN1), serotonin receptor 1D (HTR1D), tryptophan hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF), with AN and EDs characterized by regular SV. The first allele frequencies of all the SNPs were compared between a Dutch case group (182 AN, 149 EDs characterized by SV) and 607 controls. Associations rendering P-values <0.05 from this initial study were then tested for replication in a meta-analysis with two additional independent ED case-control samples, together providing 887 AN cases, 306 cases with an ED characterized by SV and 1914 controls. A significant effect for the minor C-allele of tryptophan hydroxylase 2 rs1473473 was observed for both AN [odds ratio (OR) = 1.30, 95% CI 1.08-1.57, P <0.003] and EDs characterized by SV (OR = 1.52, 95% CI 1.28-2.04, P <0.006). In the combined case group, a dominant effect was observed for rs1473473 (OR = 1.38, 95% CI 1.16-1.64, P <0.0003). The meta-analysis revealed that the tryptophan hydroxylase 2 polymorphism rs1473473 was associated with a higher risk for AN, EDs characterized by SV and for the combined group
AB - Twin studies suggest that genetic factors play a substantial role in anorexia nervosa (AN) and self-induced vomiting (SV), a key symptom that is shared among different types of eating disorders (EDs). We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of the common variance in candidate genes, stathmin (STMN1), serotonin receptor 1D (HTR1D), tryptophan hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF), with AN and EDs characterized by regular SV. The first allele frequencies of all the SNPs were compared between a Dutch case group (182 AN, 149 EDs characterized by SV) and 607 controls. Associations rendering P-values <0.05 from this initial study were then tested for replication in a meta-analysis with two additional independent ED case-control samples, together providing 887 AN cases, 306 cases with an ED characterized by SV and 1914 controls. A significant effect for the minor C-allele of tryptophan hydroxylase 2 rs1473473 was observed for both AN [odds ratio (OR) = 1.30, 95% CI 1.08-1.57, P <0.003] and EDs characterized by SV (OR = 1.52, 95% CI 1.28-2.04, P <0.006). In the combined case group, a dominant effect was observed for rs1473473 (OR = 1.38, 95% CI 1.16-1.64, P <0.0003). The meta-analysis revealed that the tryptophan hydroxylase 2 polymorphism rs1473473 was associated with a higher risk for AN, EDs characterized by SV and for the combined group
U2 - 10.1111/j.1601-183X.2010.00660.x
DO - 10.1111/j.1601-183X.2010.00660.x
M3 - Article
C2 - 20946355
SN - 1601-1848
VL - 10
SP - 236
EP - 243
JO - Genes, brain, and behavior
JF - Genes, brain, and behavior
IS - 2
ER -