Assembly of microarrays for genome-wide measurement of DNA copy number

Antoine M. Snijders; Norma Nowak; Richard Segraves; Stephanie Blackwood; Nils Brown; Jeffrey Conroy; Greg Hamilton; Anna Katherine Hindle; Bing Huey; Karen Kimura; Sindy Law; Ken Myambo; Joel Palmer; Bauke Ylstra; Jingzhu Pearl Yue; Joe W. Gray; Ajay N. Jain; Daniel Pinkel; Donna G. Albertson

doi:10.1038/ng754

Assembly of microarrays for genome-wide measurement of DNA copy number

Antoine M. Snijders
, Norma Nowak
, Richard Segraves
, Stephanie Blackwood
, Nils Brown
, Jeffrey Conroy
, Greg Hamilton
, Anna Katherine Hindle
, Bing Huey
, Karen Kimura
, Sindy Law
, Ken Myambo
, Joel Palmer
, Bauke Ylstra
, Jingzhu Pearl Yue
, Joe W. Gray
, Ajay N. Jain
, Daniel Pinkel
, Donna G. Albertson^*

^*Corresponding author for this work

University of California at San Francisco
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log₂ ratios=0.05-0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.

Original language	English
Pages (from-to)	263-264
Number of pages	2
Journal	Nature genetics
Volume	29
Issue number	3
DOIs	https://doi.org/10.1038/ng754
Publication status	Published - 10 Dec 2001

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Snijders, A. M., Nowak, N., Segraves, R., Blackwood, S., Brown, N., Conroy, J., Hamilton, G., Hindle, A. K., Huey, B., Kimura, K., Law, S., Myambo, K., Palmer, J., Ylstra, B., Yue, J. P., Gray, J. W., Jain, A. N., Pinkel, D., & Albertson, D. G. (2001). Assembly of microarrays for genome-wide measurement of DNA copy number. Nature genetics, 29(3), 263-264. https://doi.org/10.1038/ng754

@article{c7a4ca8c2680475390a3ba2f4a47373e,

title = "Assembly of microarrays for genome-wide measurement of DNA copy number",

abstract = "We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log2 ratios=0.05-0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.",

author = "Snijders, \{Antoine M.\} and Norma Nowak and Richard Segraves and Stephanie Blackwood and Nils Brown and Jeffrey Conroy and Greg Hamilton and Hindle, \{Anna Katherine\} and Bing Huey and Karen Kimura and Sindy Law and Ken Myambo and Joel Palmer and Bauke Ylstra and Yue, \{Jingzhu Pearl\} and Gray, \{Joe W.\} and Jain, \{Ajay N.\} and Daniel Pinkel and Albertson, \{Donna G.\}",

year = "2001",

month = dec,

day = "10",

doi = "10.1038/ng754",

language = "English",

volume = "29",

pages = "263--264",

journal = "Nature genetics",

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T1 - Assembly of microarrays for genome-wide measurement of DNA copy number

AU - Snijders, Antoine M.

AU - Nowak, Norma

AU - Segraves, Richard

AU - Blackwood, Stephanie

AU - Brown, Nils

AU - Conroy, Jeffrey

AU - Hamilton, Greg

AU - Hindle, Anna Katherine

AU - Huey, Bing

AU - Kimura, Karen

AU - Law, Sindy

AU - Myambo, Ken

AU - Palmer, Joel

AU - Ylstra, Bauke

AU - Yue, Jingzhu Pearl

AU - Gray, Joe W.

AU - Jain, Ajay N.

AU - Pinkel, Daniel

AU - Albertson, Donna G.

PY - 2001/12/10

Y1 - 2001/12/10

N2 - We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log2 ratios=0.05-0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.

AB - We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log2 ratios=0.05-0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.

UR - https://www.scopus.com/pages/publications/0035179871

U2 - 10.1038/ng754

DO - 10.1038/ng754

M3 - Article

C2 - 11687795

SN - 1061-4036

VL - 29

SP - 263

EP - 264

JO - Nature genetics

JF - Nature genetics

IS - 3

ER -

Assembly of microarrays for genome-wide measurement of DNA copy number

Abstract

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