Are gastrointestinal problems, nutritional care, and nutritional care needs associated with quality of life in patients with advanced cancer? Results of the observational eQuiPe study

Savvas Paschos; Nora Lize; Simone Eussen; Annemieke van der Padt-Pruijsten; Marieke van den Beuken-van Everdingen; Hanneke van Laarhoven; Marien den Boer; Alexander de Graeff; Ben van den Borne; Herma ten Have; Marjolanda Kennis; Sandra Beijer; Natasja J. H. Raijmakers; Lonneke van de Poll-Franse

doi:10.1007/s00520-023-07646-1

Are gastrointestinal problems, nutritional care, and nutritional care needs associated with quality of life in patients with advanced cancer? Results of the observational eQuiPe study

Savvas Paschos
, Nora Lize
, Simone Eussen
, Annemieke van der Padt-Pruijsten
, Marieke van den Beuken-van Everdingen
, Hanneke van Laarhoven
, Marien den Boer
, Alexander de Graeff
, Ben van den Borne
, Herma ten Have
, Marjolanda Kennis
, Sandra Beijer
, Natasja J. H. Raijmakers^*
, Lonneke van de Poll-Franse

^*Corresponding author for this work

Netherlands comprehensive cancer organisation (IKNL), Utrecht, the Netherlands.
Maastricht University
Maasstad Hospital
Maastricht UMC+
Amsterdam UMC
Department of Cardiology, Laurentius Hospital, Roermond, The Netherlands
University Medical Center Utrecht
Catharina Hospital
Careyn
Institute Verbeeten, Radiotherapy, Tilburg, The Netherlands
General Practice Klein Vlijmen
Netherlands Association for Palliative Care (PZNL), Utrecht, the Netherlands
Netherlands Cancer Institute
Tilburg University
Comprehensive Cancer Organization the Netherlands (IKNL)
Maastricht University Medical Center and Cardiovascular Research Institute Maastricht (CARIM)
Laurentius Hospital
Utrecht University
Institute Verbeeten

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Purpose: To assess the association of gastrointestinal problems, received nutritional care, and nutritional care needs with quality of life (QoL) in patients with advanced cancer. Methods: A cross-sectional analysis within the observational prospective eQuiPe cohort study on experienced quality of care and QoL in patients with advanced cancer was performed. QoL and gastrointestinal problems were measured using the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-C30. Received nutritional care (yes/no) and nutritional care needs (yes/a little bit/no) were measured by two questions. Gastrointestinal problems were categorized as clinically important based on the Giesinger thresholds. Univariable and multivariable linear regression analyses adjusted for age, gender, and treatment were used to analyze the association of gastrointestinal problems, received nutritional care, and nutritional care needs with QoL. Results: Half of the 1080 patients with advanced cancer had clinically important gastrointestinal problems, 17% experienced nutritional care needs, and 14% received nutritional care. Multivariable analyses revealed that the presence of clinically important gastrointestinal problems (β (95% CI): −13.0 (−15.6; −10.4)), received nutritional care (β (95% CI): −5.1 (−8.5; −1.7)), and nutritional care needs (β (95% CI): −8.7 (−11.9; −5.5)) were associated with a low QoL. Conclusion: Many patients with advanced cancer experience gastrointestinal problems, while only few patients receive nutritional care. These gastrointestinal problems, nutritional care needs, and nutritional care are associated with lower QoL, probably due to reversed causality or the irreversible nature of these problems in the palliative phase. More research on the relation of nutritional care, gastrointestinal problems, and QoL is needed to optimize nutritional support in end-of-life care.

Original language	English
Article number	189
Journal	Supportive care in cancer
Volume	31
Issue number	3
DOIs	https://doi.org/10.1007/s00520-023-07646-1
Publication status	Published - 1 Mar 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Advanced cancer
Gastrointestinal problems
Nutritional care
Nutritional care needs
Palliative care
Quality of life

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Are-gastrointestinal-problems-nutritional-care-and-nutritional-care-needs-associated-with-quality-of-life-in-patients-.pdfFinal published version, 645 KBLicence: Taverne

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Paschos, S., Lize, N., Eussen, S., van der Padt-Pruijsten, A., van den Beuken-van Everdingen, M., van Laarhoven, H., den Boer, M., de Graeff, A., van den Borne, B., ten Have, H., Kennis, M., Beijer, S., Raijmakers, N. J. H., & van de Poll-Franse, L. (2023). Are gastrointestinal problems, nutritional care, and nutritional care needs associated with quality of life in patients with advanced cancer? Results of the observational eQuiPe study. Supportive care in cancer, 31(3), Article 189. https://doi.org/10.1007/s00520-023-07646-1

@article{dfac11400b4f4ce6a6d7ae080ae159c8,

title = "Are gastrointestinal problems, nutritional care, and nutritional care needs associated with quality of life in patients with advanced cancer? Results of the observational eQuiPe study",

abstract = "Purpose: To assess the association of gastrointestinal problems, received nutritional care, and nutritional care needs with quality of life (QoL) in patients with advanced cancer. Methods: A cross-sectional analysis within the observational prospective eQuiPe cohort study on experienced quality of care and QoL in patients with advanced cancer was performed. QoL and gastrointestinal problems were measured using the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-C30. Received nutritional care (yes/no) and nutritional care needs (yes/a little bit/no) were measured by two questions. Gastrointestinal problems were categorized as clinically important based on the Giesinger thresholds. Univariable and multivariable linear regression analyses adjusted for age, gender, and treatment were used to analyze the association of gastrointestinal problems, received nutritional care, and nutritional care needs with QoL. Results: Half of the 1080 patients with advanced cancer had clinically important gastrointestinal problems, 17\% experienced nutritional care needs, and 14\% received nutritional care. Multivariable analyses revealed that the presence of clinically important gastrointestinal problems (β (95\% CI): −13.0 (−15.6; −10.4)), received nutritional care (β (95\% CI): −5.1 (−8.5; −1.7)), and nutritional care needs (β (95\% CI): −8.7 (−11.9; −5.5)) were associated with a low QoL. Conclusion: Many patients with advanced cancer experience gastrointestinal problems, while only few patients receive nutritional care. These gastrointestinal problems, nutritional care needs, and nutritional care are associated with lower QoL, probably due to reversed causality or the irreversible nature of these problems in the palliative phase. More research on the relation of nutritional care, gastrointestinal problems, and QoL is needed to optimize nutritional support in end-of-life care.",

keywords = "Advanced cancer, Gastrointestinal problems, Nutritional care, Nutritional care needs, Palliative care, Quality of life",

author = "Savvas Paschos and Nora Lize and Simone Eussen and \{van der Padt-Pruijsten\}, Annemieke and \{van den Beuken-van Everdingen\}, Marieke and \{van Laarhoven\}, Hanneke and \{den Boer\}, Marien and \{de Graeff\}, Alexander and \{van den Borne\}, Ben and \{ten Have\}, Herma and Marjolanda Kennis and Sandra Beijer and Raijmakers, \{Natasja J. H.\} and \{van de Poll-Franse\}, Lonneke",

note = "Funding Information: The eQuiPe study is funded by the Roparun Foundation. Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2023",

month = mar,

day = "1",

doi = "10.1007/s00520-023-07646-1",

language = "English",

volume = "31",

journal = "Supportive care in cancer",

issn = "0941-4355",

publisher = "Springer Verlag",

number = "3",

}

Paschos, S, Lize, N, Eussen, S, van der Padt-Pruijsten, A, van den Beuken-van Everdingen, M, van Laarhoven, H, den Boer, M, de Graeff, A, van den Borne, B, ten Have, H, Kennis, M, Beijer, S, Raijmakers, NJH & van de Poll-Franse, L 2023, 'Are gastrointestinal problems, nutritional care, and nutritional care needs associated with quality of life in patients with advanced cancer? Results of the observational eQuiPe study', Supportive care in cancer, vol. 31, no. 3, 189. https://doi.org/10.1007/s00520-023-07646-1

Are gastrointestinal problems, nutritional care, and nutritional care needs associated with quality of life in patients with advanced cancer? Results of the observational eQuiPe study. / Paschos, Savvas; Lize, Nora; Eussen, Simone et al.
In: Supportive care in cancer, Vol. 31, No. 3, 189, 01.03.2023.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Are gastrointestinal problems, nutritional care, and nutritional care needs associated with quality of life in patients with advanced cancer? Results of the observational eQuiPe study

AU - Paschos, Savvas

AU - Lize, Nora

AU - Eussen, Simone

AU - van der Padt-Pruijsten, Annemieke

AU - van den Beuken-van Everdingen, Marieke

AU - van Laarhoven, Hanneke

AU - den Boer, Marien

AU - de Graeff, Alexander

AU - van den Borne, Ben

AU - ten Have, Herma

AU - Kennis, Marjolanda

AU - Beijer, Sandra

AU - Raijmakers, Natasja J. H.

AU - van de Poll-Franse, Lonneke

N1 - Funding Information: The eQuiPe study is funded by the Roparun Foundation. Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2023/3/1

Y1 - 2023/3/1

N2 - Purpose: To assess the association of gastrointestinal problems, received nutritional care, and nutritional care needs with quality of life (QoL) in patients with advanced cancer. Methods: A cross-sectional analysis within the observational prospective eQuiPe cohort study on experienced quality of care and QoL in patients with advanced cancer was performed. QoL and gastrointestinal problems were measured using the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-C30. Received nutritional care (yes/no) and nutritional care needs (yes/a little bit/no) were measured by two questions. Gastrointestinal problems were categorized as clinically important based on the Giesinger thresholds. Univariable and multivariable linear regression analyses adjusted for age, gender, and treatment were used to analyze the association of gastrointestinal problems, received nutritional care, and nutritional care needs with QoL. Results: Half of the 1080 patients with advanced cancer had clinically important gastrointestinal problems, 17% experienced nutritional care needs, and 14% received nutritional care. Multivariable analyses revealed that the presence of clinically important gastrointestinal problems (β (95% CI): −13.0 (−15.6; −10.4)), received nutritional care (β (95% CI): −5.1 (−8.5; −1.7)), and nutritional care needs (β (95% CI): −8.7 (−11.9; −5.5)) were associated with a low QoL. Conclusion: Many patients with advanced cancer experience gastrointestinal problems, while only few patients receive nutritional care. These gastrointestinal problems, nutritional care needs, and nutritional care are associated with lower QoL, probably due to reversed causality or the irreversible nature of these problems in the palliative phase. More research on the relation of nutritional care, gastrointestinal problems, and QoL is needed to optimize nutritional support in end-of-life care.

AB - Purpose: To assess the association of gastrointestinal problems, received nutritional care, and nutritional care needs with quality of life (QoL) in patients with advanced cancer. Methods: A cross-sectional analysis within the observational prospective eQuiPe cohort study on experienced quality of care and QoL in patients with advanced cancer was performed. QoL and gastrointestinal problems were measured using the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-C30. Received nutritional care (yes/no) and nutritional care needs (yes/a little bit/no) were measured by two questions. Gastrointestinal problems were categorized as clinically important based on the Giesinger thresholds. Univariable and multivariable linear regression analyses adjusted for age, gender, and treatment were used to analyze the association of gastrointestinal problems, received nutritional care, and nutritional care needs with QoL. Results: Half of the 1080 patients with advanced cancer had clinically important gastrointestinal problems, 17% experienced nutritional care needs, and 14% received nutritional care. Multivariable analyses revealed that the presence of clinically important gastrointestinal problems (β (95% CI): −13.0 (−15.6; −10.4)), received nutritional care (β (95% CI): −5.1 (−8.5; −1.7)), and nutritional care needs (β (95% CI): −8.7 (−11.9; −5.5)) were associated with a low QoL. Conclusion: Many patients with advanced cancer experience gastrointestinal problems, while only few patients receive nutritional care. These gastrointestinal problems, nutritional care needs, and nutritional care are associated with lower QoL, probably due to reversed causality or the irreversible nature of these problems in the palliative phase. More research on the relation of nutritional care, gastrointestinal problems, and QoL is needed to optimize nutritional support in end-of-life care.

KW - Advanced cancer

KW - Gastrointestinal problems

KW - Nutritional care

KW - Nutritional care needs

KW - Palliative care

KW - Quality of life

UR - https://www.scopus.com/pages/publications/85148970721

U2 - 10.1007/s00520-023-07646-1

DO - 10.1007/s00520-023-07646-1

M3 - Article

C2 - 36847908

SN - 0941-4355

VL - 31

JO - Supportive care in cancer

JF - Supportive care in cancer

IS - 3

M1 - 189

ER -

Paschos S, Lize N, Eussen S, van der Padt-Pruijsten A, van den Beuken-van Everdingen M, van Laarhoven H et al. Are gastrointestinal problems, nutritional care, and nutritional care needs associated with quality of life in patients with advanced cancer? Results of the observational eQuiPe study. Supportive care in cancer. 2023 Mar 1;31(3):189. doi: 10.1007/s00520-023-07646-1

Are gastrointestinal problems, nutritional care, and nutritional care needs associated with quality of life in patients with advanced cancer? Results of the observational eQuiPe study

Abstract

UN SDGs

Keywords

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