Approaches towards the synthesis of fluoro(cyclo)alkylamines

A. D. Windhorst; L. Bechger; G. W.M. Visser; W. P.M.B. Menge; R. Leurs; H. Timmerman; J. D.M. Herscheid

doi:10.1016/S0022-1139(96)03457-4

Approaches towards the synthesis of fluoro(cyclo)alkylamines

A. D. Windhorst^*
, L. Bechger
, G. W.M. Visser
, W. P.M.B. Menge
, R. Leurs
, H. Timmerman
, J. D.M. Herscheid

^*Corresponding author for this work

Vrije Universiteit Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane (1), 1-amino-7-fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a,b) and cis-4-fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.

Original language	English
Pages (from-to)	35-40
Number of pages	6
Journal	Journal of Fluorine Chemistry
Volume	80
Issue number	1
DOIs	https://doi.org/10.1016/S0022-1139(96)03457-4
Publication status	Published - 1 Sept 1996

Keywords

ω-Fluoroalkylamines
Fluorinated cyclohexylamines
Fluorination
Rapid synthesis

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10.1016/S0022-1139(96)03457-4

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title = "Approaches towards the synthesis of fluoro(cyclo)alkylamines",

abstract = "The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane (1), 1-amino-7-fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a,b) and cis-4-fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.",

keywords = "ω-Fluoroalkylamines, Fluorinated cyclohexylamines, Fluorination, Rapid synthesis",

author = "Windhorst, \{A. D.\} and L. Bechger and Visser, \{G. W.M.\} and Menge, \{W. P.M.B.\} and R. Leurs and H. Timmerman and Herscheid, \{J. D.M.\}",

year = "1996",

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doi = "10.1016/S0022-1139(96)03457-4",

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T1 - Approaches towards the synthesis of fluoro(cyclo)alkylamines

AU - Windhorst, A. D.

AU - Bechger, L.

AU - Visser, G. W.M.

AU - Menge, W. P.M.B.

AU - Leurs, R.

AU - Timmerman, H.

AU - Herscheid, J. D.M.

PY - 1996/9/1

Y1 - 1996/9/1

N2 - The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane (1), 1-amino-7-fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a,b) and cis-4-fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.

AB - The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane (1), 1-amino-7-fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a,b) and cis-4-fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.

KW - ω-Fluoroalkylamines

KW - Fluorinated cyclohexylamines

KW - Fluorination

KW - Rapid synthesis

UR - https://www.scopus.com/pages/publications/0030240035

U2 - 10.1016/S0022-1139(96)03457-4

DO - 10.1016/S0022-1139(96)03457-4

M3 - Article

SN - 0022-1139

VL - 80

SP - 35

EP - 40

JO - Journal of Fluorine Chemistry

JF - Journal of Fluorine Chemistry

IS - 1

ER -

Approaches towards the synthesis of fluoro(cyclo)alkylamines

Abstract

Keywords

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