Antagonistic effects of sequential administration of BL1521, a histone deacetylase inhibitor, and gemcitabine to neuroblastoma cells

Annemieke J. M. de Ruijter; René Leen; Jerry Hoebink; Huib N. Caron; André B. P. van Kuilenburg

doi:10.1016/j.canlet.2005.03.016

Antagonistic effects of sequential administration of BL1521, a histone deacetylase inhibitor, and gemcitabine to neuroblastoma cells

Annemieke J. M. de Ruijter
, René Leen
, Jerry Hoebink
, Huib N. Caron
, André B. P. van Kuilenburg

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Additive to synergistic induction of apoptosis has been reported as a result of sequential incubation of cancer cells with a histone deacetylase inhibitor (HDACi) and gemcitabine (dFdC), a deoxycytidine analogue with proven anti-tumour activity. This study shows that sequential treatment of two neuroblastoma cell lines with BL1521, an HDACi, and dFdC resulted in strong antagonism despite a minor increase of dFdCTP incorporation into the DNA of one cell line. Furthermore, no difference in the deoxycytidine kinase activity was observed in response to BL1521. In conclusion, cancer cells that respond to HDACi with a cell cycle arrest and differentiation may no longer be sensitive to dFdC

Original language	English
Pages (from-to)	240-246
Journal	Cancer letters
Volume	233
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2005.03.016
Publication status	Published - 2006

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10.1016/j.canlet.2005.03.016

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@article{82ad767362ef4c0f85014d293370e456,

title = "Antagonistic effects of sequential administration of BL1521, a histone deacetylase inhibitor, and gemcitabine to neuroblastoma cells",

abstract = "Additive to synergistic induction of apoptosis has been reported as a result of sequential incubation of cancer cells with a histone deacetylase inhibitor (HDACi) and gemcitabine (dFdC), a deoxycytidine analogue with proven anti-tumour activity. This study shows that sequential treatment of two neuroblastoma cell lines with BL1521, an HDACi, and dFdC resulted in strong antagonism despite a minor increase of dFdCTP incorporation into the DNA of one cell line. Furthermore, no difference in the deoxycytidine kinase activity was observed in response to BL1521. In conclusion, cancer cells that respond to HDACi with a cell cycle arrest and differentiation may no longer be sensitive to dFdC",

author = "\{de Ruijter\}, \{Annemieke J. M.\} and Ren{\'e} Leen and Jerry Hoebink and Caron, \{Huib N.\} and \{van Kuilenburg\}, \{Andr{\'e} B. P.\}",

year = "2006",

doi = "10.1016/j.canlet.2005.03.016",

language = "English",

volume = "233",

pages = "240--246",

journal = "Cancer letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Antagonistic effects of sequential administration of BL1521, a histone deacetylase inhibitor, and gemcitabine to neuroblastoma cells

AU - de Ruijter, Annemieke J. M.

AU - Leen, René

AU - Hoebink, Jerry

AU - Caron, Huib N.

AU - van Kuilenburg, André B. P.

PY - 2006

Y1 - 2006

N2 - Additive to synergistic induction of apoptosis has been reported as a result of sequential incubation of cancer cells with a histone deacetylase inhibitor (HDACi) and gemcitabine (dFdC), a deoxycytidine analogue with proven anti-tumour activity. This study shows that sequential treatment of two neuroblastoma cell lines with BL1521, an HDACi, and dFdC resulted in strong antagonism despite a minor increase of dFdCTP incorporation into the DNA of one cell line. Furthermore, no difference in the deoxycytidine kinase activity was observed in response to BL1521. In conclusion, cancer cells that respond to HDACi with a cell cycle arrest and differentiation may no longer be sensitive to dFdC

AB - Additive to synergistic induction of apoptosis has been reported as a result of sequential incubation of cancer cells with a histone deacetylase inhibitor (HDACi) and gemcitabine (dFdC), a deoxycytidine analogue with proven anti-tumour activity. This study shows that sequential treatment of two neuroblastoma cell lines with BL1521, an HDACi, and dFdC resulted in strong antagonism despite a minor increase of dFdCTP incorporation into the DNA of one cell line. Furthermore, no difference in the deoxycytidine kinase activity was observed in response to BL1521. In conclusion, cancer cells that respond to HDACi with a cell cycle arrest and differentiation may no longer be sensitive to dFdC

U2 - 10.1016/j.canlet.2005.03.016

DO - 10.1016/j.canlet.2005.03.016

M3 - Article

C2 - 15907366

SN - 0304-3835

VL - 233

SP - 240

EP - 246

JO - Cancer letters

JF - Cancer letters

IS - 2

ER -

Antagonistic effects of sequential administration of BL1521, a histone deacetylase inhibitor, and gemcitabine to neuroblastoma cells

Abstract

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