ANOCA patients with and without coronary vasomotor dysfunction present with limited electrocardiographic remodeling

Diantha J. M. Schipaanboord; Tijn P. J. Jansen; Caïa Crooijmans; N. Charlotte Onland-Moret; Suzette E. Elias-Smale; Aukelien C. Dimitriu-Leen; Pim van der Harst; Tim P. van de Hoef; René van Es; Peter Damman; Hester M. den Ruijter

doi:10.1016/j.ijcha.2024.101347

ANOCA patients with and without coronary vasomotor dysfunction present with limited electrocardiographic remodeling

Diantha J. M. Schipaanboord
, Tijn P. J. Jansen
, Caïa Crooijmans
, N. Charlotte Onland-Moret
, Suzette E. Elias-Smale
, Aukelien C. Dimitriu-Leen
, Pim van der Harst
, Tim P. van de Hoef
, René van Es
, Peter Damman
, Hester M. den Ruijter^*

^*Corresponding author for this work

Utrecht University
Radboud University Nijmegen

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Coronary vasomotor dysfunction (CVDys) comprises coronary vasospasm (CVS) and/or coronary microvascular dysfunction (CMD) and is highly prevalent in patients with angina and non-obstructive coronary artery disease (ANOCA). Invasive coronary function testing (CFT) to diagnose CVDys is becoming more common, enabling pathophysiologic research of CVDys. This study aims to explore the electrophysiological characteristics of ANOCA patients with CVDys. Methods: We collected pre-procedural 12-lead electrocardiograms of ANOCA patients with CVS (n = 35), CMD (n = 24), CVS/CMD (n = 26) and patients without CVDys (CFT-, n = 23) who participated in the NL-CFT registry and underwent CFT. Heart axis and conduction times were compared between patients with CVS, CMD or CVS/CMD and patients without CVDys. Results: Heart axis, heart rate, PQ interval and QRS duration were comparable between the groups. A small prolongation of the QT-interval corrected with Bazett (QTcB) and Fridericia (QTcF) was observed in patients with CVDys compared to patients without CVDys (CVS vs CFT-: QTcB = 422 ± 18 vs 414 ± 18 ms (p = 0.14), QTcF = 410 ± 14 vs 406 ± 12 ms (p = 0.21); CMD vs CFT-: QTcB = 426 ± 17 vs 414 ± 18 ms (p = 0.03), QTcF = 413 ± 11 vs 406 ± 12 ms (p = 0.04); CVS/CMD vs CFT-: QTcB = 424 ± 17 vs 414 ± 18 ms (p = 0.05), QTcF = 414 ± 14 vs 406 ± 12 ms (p = 0.04)). Conclusions: Pre-procedural 12-lead electrocardiograms were comparable between patients with and without CVDys undergoing CFT except for a slightly longer QTc interval in patients with CVDys compared to patients without CVDys, suggesting limited cardiac remodeling in patients with CVDys.

Original language	English
Article number	101347
Journal	IJC Heart and Vasculature
Volume	50
DOIs	https://doi.org/10.1016/j.ijcha.2024.101347
Publication status	Published - 1 Feb 2024
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Coronary microvascular dysfunction
Coronary spasm
Coronary vasomotor dysfunction
Electrocardiography
QTc interval

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Schipaanboord, D. J. M., Jansen, T. P. J., Crooijmans, C., Onland-Moret, N. C., Elias-Smale, S. E., Dimitriu-Leen, A. C., van der Harst, P., van de Hoef, T. P., van Es, R., Damman, P., & den Ruijter, H. M. (2024). ANOCA patients with and without coronary vasomotor dysfunction present with limited electrocardiographic remodeling. IJC Heart and Vasculature, 50, Article 101347. https://doi.org/10.1016/j.ijcha.2024.101347

@article{38e0537e487c4989880aa210c3f969c9,

title = "ANOCA patients with and without coronary vasomotor dysfunction present with limited electrocardiographic remodeling",

abstract = "Background: Coronary vasomotor dysfunction (CVDys) comprises coronary vasospasm (CVS) and/or coronary microvascular dysfunction (CMD) and is highly prevalent in patients with angina and non-obstructive coronary artery disease (ANOCA). Invasive coronary function testing (CFT) to diagnose CVDys is becoming more common, enabling pathophysiologic research of CVDys. This study aims to explore the electrophysiological characteristics of ANOCA patients with CVDys. Methods: We collected pre-procedural 12-lead electrocardiograms of ANOCA patients with CVS (n = 35), CMD (n = 24), CVS/CMD (n = 26) and patients without CVDys (CFT-, n = 23) who participated in the NL-CFT registry and underwent CFT. Heart axis and conduction times were compared between patients with CVS, CMD or CVS/CMD and patients without CVDys. Results: Heart axis, heart rate, PQ interval and QRS duration were comparable between the groups. A small prolongation of the QT-interval corrected with Bazett (QTcB) and Fridericia (QTcF) was observed in patients with CVDys compared to patients without CVDys (CVS vs CFT-: QTcB = 422 ± 18 vs 414 ± 18 ms (p = 0.14), QTcF = 410 ± 14 vs 406 ± 12 ms (p = 0.21); CMD vs CFT-: QTcB = 426 ± 17 vs 414 ± 18 ms (p = 0.03), QTcF = 413 ± 11 vs 406 ± 12 ms (p = 0.04); CVS/CMD vs CFT-: QTcB = 424 ± 17 vs 414 ± 18 ms (p = 0.05), QTcF = 414 ± 14 vs 406 ± 12 ms (p = 0.04)). Conclusions: Pre-procedural 12-lead electrocardiograms were comparable between patients with and without CVDys undergoing CFT except for a slightly longer QTc interval in patients with CVDys compared to patients without CVDys, suggesting limited cardiac remodeling in patients with CVDys.",

keywords = "Coronary microvascular dysfunction, Coronary spasm, Coronary vasomotor dysfunction, Electrocardiography, QTc interval",

author = "Schipaanboord, \{Diantha J. M.\} and Jansen, \{Tijn P. J.\} and Ca{\"i}a Crooijmans and Onland-Moret, \{N. Charlotte\} and Elias-Smale, \{Suzette E.\} and Dimitriu-Leen, \{Aukelien C.\} and \{van der Harst\}, Pim and \{van de Hoef\}, \{Tim P.\} and \{van Es\}, Ren{\'e} and Peter Damman and \{den Ruijter\}, \{Hester M.\}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = feb,

day = "1",

doi = "10.1016/j.ijcha.2024.101347",

language = "English",

volume = "50",

journal = "IJC Heart and Vasculature",

issn = "2352-9067",

publisher = "Elsevier BV",

}

Schipaanboord, DJM, Jansen, TPJ, Crooijmans, C, Onland-Moret, NC, Elias-Smale, SE, Dimitriu-Leen, AC, van der Harst, P, van de Hoef, TP, van Es, R, Damman, P & den Ruijter, HM 2024, 'ANOCA patients with and without coronary vasomotor dysfunction present with limited electrocardiographic remodeling', IJC Heart and Vasculature, vol. 50, 101347. https://doi.org/10.1016/j.ijcha.2024.101347

TY - JOUR

T1 - ANOCA patients with and without coronary vasomotor dysfunction present with limited electrocardiographic remodeling

AU - Schipaanboord, Diantha J. M.

AU - Jansen, Tijn P. J.

AU - Crooijmans, Caïa

AU - Onland-Moret, N. Charlotte

AU - Elias-Smale, Suzette E.

AU - Dimitriu-Leen, Aukelien C.

AU - van der Harst, Pim

AU - van de Hoef, Tim P.

AU - van Es, René

AU - Damman, Peter

AU - den Ruijter, Hester M.

PY - 2024/2/1

Y1 - 2024/2/1

N2 - Background: Coronary vasomotor dysfunction (CVDys) comprises coronary vasospasm (CVS) and/or coronary microvascular dysfunction (CMD) and is highly prevalent in patients with angina and non-obstructive coronary artery disease (ANOCA). Invasive coronary function testing (CFT) to diagnose CVDys is becoming more common, enabling pathophysiologic research of CVDys. This study aims to explore the electrophysiological characteristics of ANOCA patients with CVDys. Methods: We collected pre-procedural 12-lead electrocardiograms of ANOCA patients with CVS (n = 35), CMD (n = 24), CVS/CMD (n = 26) and patients without CVDys (CFT-, n = 23) who participated in the NL-CFT registry and underwent CFT. Heart axis and conduction times were compared between patients with CVS, CMD or CVS/CMD and patients without CVDys. Results: Heart axis, heart rate, PQ interval and QRS duration were comparable between the groups. A small prolongation of the QT-interval corrected with Bazett (QTcB) and Fridericia (QTcF) was observed in patients with CVDys compared to patients without CVDys (CVS vs CFT-: QTcB = 422 ± 18 vs 414 ± 18 ms (p = 0.14), QTcF = 410 ± 14 vs 406 ± 12 ms (p = 0.21); CMD vs CFT-: QTcB = 426 ± 17 vs 414 ± 18 ms (p = 0.03), QTcF = 413 ± 11 vs 406 ± 12 ms (p = 0.04); CVS/CMD vs CFT-: QTcB = 424 ± 17 vs 414 ± 18 ms (p = 0.05), QTcF = 414 ± 14 vs 406 ± 12 ms (p = 0.04)). Conclusions: Pre-procedural 12-lead electrocardiograms were comparable between patients with and without CVDys undergoing CFT except for a slightly longer QTc interval in patients with CVDys compared to patients without CVDys, suggesting limited cardiac remodeling in patients with CVDys.

AB - Background: Coronary vasomotor dysfunction (CVDys) comprises coronary vasospasm (CVS) and/or coronary microvascular dysfunction (CMD) and is highly prevalent in patients with angina and non-obstructive coronary artery disease (ANOCA). Invasive coronary function testing (CFT) to diagnose CVDys is becoming more common, enabling pathophysiologic research of CVDys. This study aims to explore the electrophysiological characteristics of ANOCA patients with CVDys. Methods: We collected pre-procedural 12-lead electrocardiograms of ANOCA patients with CVS (n = 35), CMD (n = 24), CVS/CMD (n = 26) and patients without CVDys (CFT-, n = 23) who participated in the NL-CFT registry and underwent CFT. Heart axis and conduction times were compared between patients with CVS, CMD or CVS/CMD and patients without CVDys. Results: Heart axis, heart rate, PQ interval and QRS duration were comparable between the groups. A small prolongation of the QT-interval corrected with Bazett (QTcB) and Fridericia (QTcF) was observed in patients with CVDys compared to patients without CVDys (CVS vs CFT-: QTcB = 422 ± 18 vs 414 ± 18 ms (p = 0.14), QTcF = 410 ± 14 vs 406 ± 12 ms (p = 0.21); CMD vs CFT-: QTcB = 426 ± 17 vs 414 ± 18 ms (p = 0.03), QTcF = 413 ± 11 vs 406 ± 12 ms (p = 0.04); CVS/CMD vs CFT-: QTcB = 424 ± 17 vs 414 ± 18 ms (p = 0.05), QTcF = 414 ± 14 vs 406 ± 12 ms (p = 0.04)). Conclusions: Pre-procedural 12-lead electrocardiograms were comparable between patients with and without CVDys undergoing CFT except for a slightly longer QTc interval in patients with CVDys compared to patients without CVDys, suggesting limited cardiac remodeling in patients with CVDys.

KW - Coronary microvascular dysfunction

KW - Coronary spasm

KW - Coronary vasomotor dysfunction

KW - Electrocardiography

KW - QTc interval

UR - https://www.scopus.com/pages/publications/85184059465

U2 - 10.1016/j.ijcha.2024.101347

DO - 10.1016/j.ijcha.2024.101347

M3 - Article

C2 - 38322017

SN - 2352-9067

VL - 50

JO - IJC Heart and Vasculature

JF - IJC Heart and Vasculature

M1 - 101347

ER -

ANOCA patients with and without coronary vasomotor dysfunction present with limited electrocardiographic remodeling

Abstract

UN SDGs

Keywords

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