An individual participant data meta-analysis of psychological interventions for preventing depression relapse

Josefien J.F. Breedvelt; Eirini Karyotaki; Fiona C. Warren; Marlies E. Brouwer; Françoise Jermann; Fredrik Hollandare; Nicola Klein; Margo de Jonge; Daniel N. Klein; Norman Farb; Zindel Segal; Karolien E.M. Biesheuvel Leliefeld; Robin Jarrett; Jeffrey Vittengl; Michael Thase; Helen Ma; Willem Kuyken; Amanda J. Shallcross; Cornelis van Heeringen; Kristof Hoorelbeke; Ernst Koster; Mark Williams; Marloes J. Huijbers; Anne Speckens; Pim Cuijpers; Patricia van Oppen; Simon Gilbody; Claudi L. Bockting

doi:10.1038/s44220-023-00178-x

An individual participant data meta-analysis of psychological interventions for preventing depression relapse

Josefien J.F. Breedvelt^*
, Eirini Karyotaki
, Fiona C. Warren
, Marlies E. Brouwer
, Françoise Jermann
, Fredrik Hollandare
, Nicola Klein
, Margo de Jonge
, Daniel N. Klein
, Norman Farb
, Zindel Segal
, Karolien E.M. Biesheuvel Leliefeld
, Robin Jarrett
, Jeffrey Vittengl
, Michael Thase
, Helen Ma
, Willem Kuyken
, Amanda J. Shallcross
, Cornelis van Heeringen
, Kristof Hoorelbeke

Ernst Koster, Mark Williams, Marloes J. Huijbers, Anne Speckens, Pim Cuijpers, Patricia van Oppen, Simon Gilbody, Claudi L. Bockting

^*Corresponding author for this work

Universiteit van Amsterdam, Department of Psychiatry
University of Amsterdam
Department of Child and Adolescent Psychiatry
King's College London
Vrije Universiteit Amsterdam
University of Exeter
University of Geneva
Örebro University
GGZ Drenthe Mental Health Institute
Arkin Mental Health Institute
Stony Brook University
University of Toronto
Neuro and Developmental Psychology
University of Texas Southwestern Medical Center
Truman State University
University of Pennsylvania
Hong Kong
University of Oxford
New York University
Ghent University
Radboud University Nijmegen
Department of Research and Innovation
GGZ InGeest Specialized Mental Health Care
Vrije Universiteit Amsterdam, Department of Psychiatry
University of York
Centre for Urban Mental Health

Research output: Contribution to journal › Article › Academic › peer-review

29 Downloads (Pure)

Abstract

Major depressive disorder is a leading cause of disability worldwide; identifying effective strategies to prevent depression relapse is crucial. This individual participant data meta-analysis addresses whether and for whom psychological interventions can be recommended for relapse prevention of major depressive disorder. One- and two-stage individual patient data meta-analyses were conducted on 14 randomized controlled trials (N = 1,720). The relapse risk over 12 months was substantially lower for those who received a psychological intervention versus treatment as usual, antidepressant medication, or evaluation-only control (hazard ratio, 0.60; 95% confidence interval, 0.48–0.74). The number of previous depression episodes moderated the treatment effect, with psychological interventions demonstrating greater efficacy for patients with three or more previous episodes. Our results suggest that adding psychological interventions to current treatment to prevent depression relapse is recommended. For patients at lower risk of relapse, less-intensive approaches may be indicated.

Original language	English
Article number	50
Pages (from-to)	154-163
Number of pages	10
Journal	Nature Mental Health
Volume	2
Issue number	2
DOIs	https://doi.org/10.1038/s44220-023-00178-x
Publication status	Published - Feb 2024

Access to Document

10.1038/s44220-023-00178-x

An-individual-participant-data-meta-analysis-of-psychological-interventions-for-preventing-depression-relapse.pdfFinal published version, 3.35 MBLicence: CC BY

Cite this

Breedvelt, J. J. F., Karyotaki, E., Warren, F. C., Brouwer, M. E., Jermann, F., Hollandare, F., Klein, N., de Jonge, M., Klein, D. N., Farb, N., Segal, Z., Biesheuvel Leliefeld, K. E. M., Jarrett, R., Vittengl, J., Thase, M., Ma, H., Kuyken, W., Shallcross, A. J., van Heeringen, C., ... Bockting, C. L. (2024). An individual participant data meta-analysis of psychological interventions for preventing depression relapse. Nature Mental Health, 2(2), 154-163. Article 50. https://doi.org/10.1038/s44220-023-00178-x

@article{8ac926b262f743d9938a91caf46d3eb9,

title = "An individual participant data meta-analysis of psychological interventions for preventing depression relapse",

abstract = "Major depressive disorder is a leading cause of disability worldwide; identifying effective strategies to prevent depression relapse is crucial. This individual participant data meta-analysis addresses whether and for whom psychological interventions can be recommended for relapse prevention of major depressive disorder. One- and two-stage individual patient data meta-analyses were conducted on 14 randomized controlled trials (N = 1,720). The relapse risk over 12 months was substantially lower for those who received a psychological intervention versus treatment as usual, antidepressant medication, or evaluation-only control (hazard ratio, 0.60; 95\% confidence interval, 0.48–0.74). The number of previous depression episodes moderated the treatment effect, with psychological interventions demonstrating greater efficacy for patients with three or more previous episodes. Our results suggest that adding psychological interventions to current treatment to prevent depression relapse is recommended. For patients at lower risk of relapse, less-intensive approaches may be indicated.",

author = "Breedvelt, \{Josefien J.F.\} and Eirini Karyotaki and Warren, \{Fiona C.\} and Brouwer, \{Marlies E.\} and Fran{\c c}oise Jermann and Fredrik Hollandare and Nicola Klein and \{de Jonge\}, Margo and Klein, \{Daniel N.\} and Norman Farb and Zindel Segal and \{Biesheuvel Leliefeld\}, \{Karolien E.M.\} and Robin Jarrett and Jeffrey Vittengl and Michael Thase and Helen Ma and Willem Kuyken and Shallcross, \{Amanda J.\} and \{van Heeringen\}, Cornelis and Kristof Hoorelbeke and Ernst Koster and Mark Williams and Huijbers, \{Marloes J.\} and Anne Speckens and Pim Cuijpers and \{van Oppen\}, Patricia and Simon Gilbody and Bockting, \{Claudi L.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = feb,

doi = "10.1038/s44220-023-00178-x",

language = "English",

volume = "2",

pages = "154--163",

journal = "Nature Mental Health",

issn = "2731-6076",

number = "2",

}

Breedvelt, JJF, Karyotaki, E, Warren, FC, Brouwer, ME, Jermann, F, Hollandare, F, Klein, N, de Jonge, M, Klein, DN, Farb, N, Segal, Z, Biesheuvel Leliefeld, KEM, Jarrett, R, Vittengl, J, Thase, M, Ma, H, Kuyken, W, Shallcross, AJ, van Heeringen, C, Hoorelbeke, K, Koster, E, Williams, M, Huijbers, MJ, Speckens, A, Cuijpers, P, van Oppen, P, Gilbody, S & Bockting, CL 2024, 'An individual participant data meta-analysis of psychological interventions for preventing depression relapse', Nature Mental Health, vol. 2, no. 2, 50, pp. 154-163. https://doi.org/10.1038/s44220-023-00178-x

TY - JOUR

T1 - An individual participant data meta-analysis of psychological interventions for preventing depression relapse

AU - Breedvelt, Josefien J.F.

AU - Karyotaki, Eirini

AU - Warren, Fiona C.

AU - Brouwer, Marlies E.

AU - Jermann, Françoise

AU - Hollandare, Fredrik

AU - Klein, Nicola

AU - de Jonge, Margo

AU - Klein, Daniel N.

AU - Farb, Norman

AU - Segal, Zindel

AU - Biesheuvel Leliefeld, Karolien E.M.

AU - Jarrett, Robin

AU - Vittengl, Jeffrey

AU - Thase, Michael

AU - Ma, Helen

AU - Kuyken, Willem

AU - Shallcross, Amanda J.

AU - van Heeringen, Cornelis

AU - Hoorelbeke, Kristof

AU - Koster, Ernst

AU - Williams, Mark

AU - Huijbers, Marloes J.

AU - Speckens, Anne

AU - Cuijpers, Pim

AU - van Oppen, Patricia

AU - Gilbody, Simon

AU - Bockting, Claudi L.

PY - 2024/2

Y1 - 2024/2

N2 - Major depressive disorder is a leading cause of disability worldwide; identifying effective strategies to prevent depression relapse is crucial. This individual participant data meta-analysis addresses whether and for whom psychological interventions can be recommended for relapse prevention of major depressive disorder. One- and two-stage individual patient data meta-analyses were conducted on 14 randomized controlled trials (N = 1,720). The relapse risk over 12 months was substantially lower for those who received a psychological intervention versus treatment as usual, antidepressant medication, or evaluation-only control (hazard ratio, 0.60; 95% confidence interval, 0.48–0.74). The number of previous depression episodes moderated the treatment effect, with psychological interventions demonstrating greater efficacy for patients with three or more previous episodes. Our results suggest that adding psychological interventions to current treatment to prevent depression relapse is recommended. For patients at lower risk of relapse, less-intensive approaches may be indicated.

AB - Major depressive disorder is a leading cause of disability worldwide; identifying effective strategies to prevent depression relapse is crucial. This individual participant data meta-analysis addresses whether and for whom psychological interventions can be recommended for relapse prevention of major depressive disorder. One- and two-stage individual patient data meta-analyses were conducted on 14 randomized controlled trials (N = 1,720). The relapse risk over 12 months was substantially lower for those who received a psychological intervention versus treatment as usual, antidepressant medication, or evaluation-only control (hazard ratio, 0.60; 95% confidence interval, 0.48–0.74). The number of previous depression episodes moderated the treatment effect, with psychological interventions demonstrating greater efficacy for patients with three or more previous episodes. Our results suggest that adding psychological interventions to current treatment to prevent depression relapse is recommended. For patients at lower risk of relapse, less-intensive approaches may be indicated.

UR - https://www.scopus.com/pages/publications/85201071179

U2 - 10.1038/s44220-023-00178-x

DO - 10.1038/s44220-023-00178-x

M3 - Article

AN - SCOPUS:85201071179

SN - 2731-6076

VL - 2

SP - 154

EP - 163

JO - Nature Mental Health

JF - Nature Mental Health

IS - 2

M1 - 50

ER -

An individual participant data meta-analysis of psychological interventions for preventing depression relapse

Abstract

Access to Document

Other files and links

Fingerprint

Cite this