An antisense RNA capable of modulating the expression of the tumor suppressor microRNA-34a

Jason T. Serviss; Nathanael Andrews; Jimmy van den Eynden; Felix Clemens Richter; Miranda Houtman; Mattias Vesterlund; Laura Schwarzmueller; Per Johnsson; Erik Larsson; Dan Grandér; Katja Pokrovskaja Tamm

doi:10.1038/s41419-018-0777-5

An antisense RNA capable of modulating the expression of the tumor suppressor microRNA-34a

Jason T. Serviss^*
, Nathanael Andrews
, Jimmy van den Eynden
, Felix Clemens Richter
, Miranda Houtman
, Mattias Vesterlund
, Laura Schwarzmueller
, Per Johnsson
, Erik Larsson
, Dan Grandér
, Katja Pokrovskaja Tamm

^*Corresponding author for this work

Karolinska Institutet
University of Gothenburg
University of Oxford
Amsterdam UMC - University of Amsterdam
Ludwig Institute for Cancer Research

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The microRNA-34a is a well-studied tumor suppressor microRNA (miRNA) and a direct downstream target of TP53 with roles in several pathways associated with oncogenesis, such as proliferation, cellular growth, and differentiation. Due to its broad tumor suppressive activity, it is not surprising that miR34a expression is altered in a wide variety of solid tumors and hematological malignancies. However, the mechanisms by which miR34a is regulated in these cancers is largely unknown. In this study, we find that a long noncoding RNA transcribed antisense to the miR34a host gene, is critical for miR34a expression and mediation of its cellular functions in multiple types of human cancer. We name this long noncoding RNA lncTAM34a, and characterize its ability to facilitate miR34a expression under different types of cellular stress in both TP53-deficient and wild-type settings.

Original language	English
Article number	736
Journal	Cell death & disease
Volume	9
Issue number	7
DOIs	https://doi.org/10.1038/s41419-018-0777-5
Publication status	Published - 1 Jul 2018
Externally published	Yes

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title = "An antisense RNA capable of modulating the expression of the tumor suppressor microRNA-34a",

abstract = "The microRNA-34a is a well-studied tumor suppressor microRNA (miRNA) and a direct downstream target of TP53 with roles in several pathways associated with oncogenesis, such as proliferation, cellular growth, and differentiation. Due to its broad tumor suppressive activity, it is not surprising that miR34a expression is altered in a wide variety of solid tumors and hematological malignancies. However, the mechanisms by which miR34a is regulated in these cancers is largely unknown. In this study, we find that a long noncoding RNA transcribed antisense to the miR34a host gene, is critical for miR34a expression and mediation of its cellular functions in multiple types of human cancer. We name this long noncoding RNA lncTAM34a, and characterize its ability to facilitate miR34a expression under different types of cellular stress in both TP53-deficient and wild-type settings.",

author = "Serviss, \{Jason T.\} and Nathanael Andrews and \{van den Eynden\}, Jimmy and Richter, \{Felix Clemens\} and Miranda Houtman and Mattias Vesterlund and Laura Schwarzmueller and Per Johnsson and Erik Larsson and Dan Grand{\'e}r and \{Pokrovskaja Tamm\}, Katja",

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doi = "10.1038/s41419-018-0777-5",

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T1 - An antisense RNA capable of modulating the expression of the tumor suppressor microRNA-34a

AU - Serviss, Jason T.

AU - Andrews, Nathanael

AU - van den Eynden, Jimmy

AU - Richter, Felix Clemens

AU - Houtman, Miranda

AU - Vesterlund, Mattias

AU - Schwarzmueller, Laura

AU - Johnsson, Per

AU - Larsson, Erik

AU - Grandér, Dan

AU - Pokrovskaja Tamm, Katja

PY - 2018/7/1

Y1 - 2018/7/1

N2 - The microRNA-34a is a well-studied tumor suppressor microRNA (miRNA) and a direct downstream target of TP53 with roles in several pathways associated with oncogenesis, such as proliferation, cellular growth, and differentiation. Due to its broad tumor suppressive activity, it is not surprising that miR34a expression is altered in a wide variety of solid tumors and hematological malignancies. However, the mechanisms by which miR34a is regulated in these cancers is largely unknown. In this study, we find that a long noncoding RNA transcribed antisense to the miR34a host gene, is critical for miR34a expression and mediation of its cellular functions in multiple types of human cancer. We name this long noncoding RNA lncTAM34a, and characterize its ability to facilitate miR34a expression under different types of cellular stress in both TP53-deficient and wild-type settings.

AB - The microRNA-34a is a well-studied tumor suppressor microRNA (miRNA) and a direct downstream target of TP53 with roles in several pathways associated with oncogenesis, such as proliferation, cellular growth, and differentiation. Due to its broad tumor suppressive activity, it is not surprising that miR34a expression is altered in a wide variety of solid tumors and hematological malignancies. However, the mechanisms by which miR34a is regulated in these cancers is largely unknown. In this study, we find that a long noncoding RNA transcribed antisense to the miR34a host gene, is critical for miR34a expression and mediation of its cellular functions in multiple types of human cancer. We name this long noncoding RNA lncTAM34a, and characterize its ability to facilitate miR34a expression under different types of cellular stress in both TP53-deficient and wild-type settings.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/29970884

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JO - Cell death & disease

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An antisense RNA capable of modulating the expression of the tumor suppressor microRNA-34a

Abstract

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