Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids

Lisette I. Z. Kunz; Nick H. T. ten Hacken; Thérèse S. Lapperre; Wim Timens; Huib A. M. Kerstjens; Annemarie van Schadewijk; Judith M. Vonk; Jacob K. Sont; Jiska B. Snoeck-Stroband; Dirkje S. Postma; Peter J. Sterk; Pieter S. Hiemstra

doi:10.1183/13993003.00839-2016

Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids

Lisette I. Z. Kunz
, Nick H. T. ten Hacken
, Thérèse S. Lapperre
, Wim Timens
, Huib A. M. Kerstjens
, Annemarie van Schadewijk
, Judith M. Vonk
, Jacob K. Sont
, Jiska B. Snoeck-Stroband
, Dirkje S. Postma
, Peter J. Sterk
, Pieter S. Hiemstra

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

+cells (1.71, 95% CI 1.15-2.53), and mast cells (1.91, 95% CI 1.36-2.68). The sputum total cell counts increased significantly in GL2 (1.90, 95% CI 1.42-2.54), as did counts of macrophages (2.10, 95% CI 1.55-2.86), neutrophils (1.92, 95% CI 1.39-2.65) and lymphocytes (2.01, 95% CI 1.46-2.78).ICS discontinuation increases airway inflammation in patients with moderate-severe COPD, suggesting that the anti-inflammatory effects of ICS in COPD are not maintained after ICS discontinuation

Original language	English
Pages (from-to)	1600839
Journal	European respiratory journal
Volume	49
Issue number	1
Early online date	2017
DOIs	https://doi.org/10.1183/13993003.00839-2016
Publication status	Published - 2017

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Kunz, L. I. Z., ten Hacken, N. H. T., Lapperre, T. S., Timens, W., Kerstjens, H. A. M., van Schadewijk, A., Vonk, J. M., Sont, J. K., Snoeck-Stroband, J. B., Postma, D. S., Sterk, P. J., & Hiemstra, P. S. (2017). Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids. European respiratory journal, 49(1), 1600839. https://doi.org/10.1183/13993003.00839-2016

@article{efbe727f475b4269899cc88e328b8b42,

title = "Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids",

abstract = "+cells (1.71, 95\% CI 1.15-2.53), and mast cells (1.91, 95\% CI 1.36-2.68). The sputum total cell counts increased significantly in GL2 (1.90, 95\% CI 1.42-2.54), as did counts of macrophages (2.10, 95\% CI 1.55-2.86), neutrophils (1.92, 95\% CI 1.39-2.65) and lymphocytes (2.01, 95\% CI 1.46-2.78).ICS discontinuation increases airway inflammation in patients with moderate-severe COPD, suggesting that the anti-inflammatory effects of ICS in COPD are not maintained after ICS discontinuation",

author = "Kunz, \{Lisette I. Z.\} and \{ten Hacken\}, \{Nick H. T.\} and Lapperre, \{Th{\'e}r{\`e}se S.\} and Wim Timens and Kerstjens, \{Huib A. M.\} and \{van Schadewijk\}, Annemarie and Vonk, \{Judith M.\} and Sont, \{Jacob K.\} and Snoeck-Stroband, \{Jiska B.\} and Postma, \{Dirkje S.\} and Sterk, \{Peter J.\} and Hiemstra, \{Pieter S.\}",

note = "Onterecht samengevoegd met PMID 28619964",

year = "2017",

doi = "10.1183/13993003.00839-2016",

language = "English",

volume = "49",

pages = "1600839",

journal = "European respiratory journal",

issn = "0903-1936",

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T1 - Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids

AU - Kunz, Lisette I. Z.

AU - ten Hacken, Nick H. T.

AU - Lapperre, Thérèse S.

AU - Timens, Wim

AU - Kerstjens, Huib A. M.

AU - van Schadewijk, Annemarie

AU - Vonk, Judith M.

AU - Sont, Jacob K.

AU - Snoeck-Stroband, Jiska B.

AU - Postma, Dirkje S.

AU - Sterk, Peter J.

AU - Hiemstra, Pieter S.

N1 - Onterecht samengevoegd met PMID 28619964

PY - 2017

Y1 - 2017

N2 - +cells (1.71, 95% CI 1.15-2.53), and mast cells (1.91, 95% CI 1.36-2.68). The sputum total cell counts increased significantly in GL2 (1.90, 95% CI 1.42-2.54), as did counts of macrophages (2.10, 95% CI 1.55-2.86), neutrophils (1.92, 95% CI 1.39-2.65) and lymphocytes (2.01, 95% CI 1.46-2.78).ICS discontinuation increases airway inflammation in patients with moderate-severe COPD, suggesting that the anti-inflammatory effects of ICS in COPD are not maintained after ICS discontinuation

AB - +cells (1.71, 95% CI 1.15-2.53), and mast cells (1.91, 95% CI 1.36-2.68). The sputum total cell counts increased significantly in GL2 (1.90, 95% CI 1.42-2.54), as did counts of macrophages (2.10, 95% CI 1.55-2.86), neutrophils (1.92, 95% CI 1.39-2.65) and lymphocytes (2.01, 95% CI 1.46-2.78).ICS discontinuation increases airway inflammation in patients with moderate-severe COPD, suggesting that the anti-inflammatory effects of ICS in COPD are not maintained after ICS discontinuation

U2 - 10.1183/13993003.00839-2016

DO - 10.1183/13993003.00839-2016

M3 - Article

C2 - 28049170

SN - 0903-1936

VL - 49

SP - 1600839

JO - European respiratory journal

JF - European respiratory journal

IS - 1

ER -

Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids

Abstract

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