Age, Sex and Racial Differences in Cardiac Repolarization and Arrhythmogenesis

Arja Suzanne Vink; Sally-Ann B. Clur; Pieter G. Postema; Nico A. Blom; Arthur A. M. Wilde

doi:10.1007/978-3-030-22672-5_6

Age, Sex and Racial Differences in Cardiac Repolarization and Arrhythmogenesis

^*Corresponding author for this work

Leiden University Medical Center
University of Amsterdam
Leiden University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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Abstract

Age, sex and race have an influence on the cardiac repolarization and therefore the QTc-interval. Racial differences are probably the result of the presence of considerable heterogeneity among race/ethnicity for multiple genetic loci that influence the QT-interval. Age-and sex-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of the effect of sex hormones on the QTc-interval and arrhythmogenesis are not known, testosterone appears to shorten the QTc-interval in males. In females, however, there is a more complex interaction between progesterone and oestrogen. In addition, the autonomic nervous system and gonadotropins may play an important part in this complex interaction.

Original language	English
Title of host publication	Cardiac Repolarization: Basic Science and Clinical Management
Publisher	Springer International Publishing
Pages	119-129
Number of pages	11
ISBN (Electronic)	9783030226725
ISBN (Print)	9783030226718
DOIs	https://doi.org/10.1007/978-3-030-22672-5_6 https://doi.org/10.1007/978-3-030-22672-5_6
Publication status	Published - 1 Jan 2019

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Name	Cardiac Repolarization: Basic Science and Clinical Management

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Vink, A. S., Clur, S.-A. B., Postema, P. G., Blom, N. A., & Wilde, A. A. M. (2019). Age, Sex and Racial Differences in Cardiac Repolarization and Arrhythmogenesis. In Cardiac Repolarization: Basic Science and Clinical Management (pp. 119-129). (Cardiac Repolarization: Basic Science and Clinical Management). Springer International Publishing. https://doi.org/10.1007/978-3-030-22672-5_6, https://doi.org/10.1007/978-3-030-22672-5_6

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abstract = "Age, sex and race have an influence on the cardiac repolarization and therefore the QTc-interval. Racial differences are probably the result of the presence of considerable heterogeneity among race/ethnicity for multiple genetic loci that influence the QT-interval. Age-and sex-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of the effect of sex hormones on the QTc-interval and arrhythmogenesis are not known, testosterone appears to shorten the QTc-interval in males. In females, however, there is a more complex interaction between progesterone and oestrogen. In addition, the autonomic nervous system and gonadotropins may play an important part in this complex interaction.",

author = "Vink, \{Arja Suzanne\} and Clur, \{Sally-Ann B.\} and Postema, \{Pieter G.\} and Blom, \{Nico A.\} and Wilde, \{Arthur A. M.\}",

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Vink, AS , Clur, S-AB , Postema, PG , Blom, NA & Wilde, AAM 2019, Age, Sex and Racial Differences in Cardiac Repolarization and Arrhythmogenesis. in Cardiac Repolarization: Basic Science and Clinical Management. Cardiac Repolarization: Basic Science and Clinical Management, Springer International Publishing, pp. 119-129. https://doi.org/10.1007/978-3-030-22672-5_6, https://doi.org/10.1007/978-3-030-22672-5_6

Age, Sex and Racial Differences in Cardiac Repolarization and Arrhythmogenesis. / Vink, Arja Suzanne ; Clur, Sally-Ann B.; Postema, Pieter G. et al.
Cardiac Repolarization: Basic Science and Clinical Management. Springer International Publishing, 2019. p. 119-129 (Cardiac Repolarization: Basic Science and Clinical Management).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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AB - Age, sex and race have an influence on the cardiac repolarization and therefore the QTc-interval. Racial differences are probably the result of the presence of considerable heterogeneity among race/ethnicity for multiple genetic loci that influence the QT-interval. Age-and sex-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of the effect of sex hormones on the QTc-interval and arrhythmogenesis are not known, testosterone appears to shorten the QTc-interval in males. In females, however, there is a more complex interaction between progesterone and oestrogen. In addition, the autonomic nervous system and gonadotropins may play an important part in this complex interaction.

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Vink AS , Clur SAB , Postema PG , Blom NA , Wilde AAM. Age, Sex and Racial Differences in Cardiac Repolarization and Arrhythmogenesis. In Cardiac Repolarization: Basic Science and Clinical Management. Springer International Publishing. 2019. p. 119-129. (Cardiac Repolarization: Basic Science and Clinical Management). Epub 2019. doi: 10.1007/978-3-030-22672-5_6, 10.1007/978-3-030-22672-5_6

Age, Sex and Racial Differences in Cardiac Repolarization and Arrhythmogenesis

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