Addressing Diffuse Glioma as a Systemic Brain Disease With Single-Cell Analysis

Felix Sahm; David Capper; Astrid Jeibmann; Antje Habel; Werner Paulus; Dirk Troost; Andreas von Deimling

doi:10.1001/archneurol.2011.2910

Addressing Diffuse Glioma as a Systemic Brain Disease With Single-Cell Analysis

Felix Sahm
, David Capper
, Astrid Jeibmann
, Antje Habel
, Werner Paulus
, Dirk Troost
, Andreas von Deimling

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: To analyze infiltration patterns of IDH1 mutant diffuse gliomas into the brain by identification of single tumor cells applying an antibody specific to mutant IDH1 R132H protein. Design: Immunohistochemical analysis. Setting: University hospital. Patients: Whole-brain and hemisphere sections of 4 patients diagnosed with diffuse glioma. Results: Tumor cells were identified in areas that appeared inconspicuous macroscopically and at histological analysis with respect to cellularity, cellular pleomorphism, or mitotic activity in all cases. Conclusion: Detection of single tumor cells throughout the brain demonstrates diffuse glioma to represent systemic brain disease

Original language	English
Pages (from-to)	523-526
Journal	Archives of neurology
Volume	69
Issue number	4
DOIs	https://doi.org/10.1001/archneurol.2011.2910
Publication status	Published - 2012

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10.1001/archneurol.2011.2910

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title = "Addressing Diffuse Glioma as a Systemic Brain Disease With Single-Cell Analysis",

abstract = "Objective: To analyze infiltration patterns of IDH1 mutant diffuse gliomas into the brain by identification of single tumor cells applying an antibody specific to mutant IDH1 R132H protein. Design: Immunohistochemical analysis. Setting: University hospital. Patients: Whole-brain and hemisphere sections of 4 patients diagnosed with diffuse glioma. Results: Tumor cells were identified in areas that appeared inconspicuous macroscopically and at histological analysis with respect to cellularity, cellular pleomorphism, or mitotic activity in all cases. Conclusion: Detection of single tumor cells throughout the brain demonstrates diffuse glioma to represent systemic brain disease",

author = "Felix Sahm and David Capper and Astrid Jeibmann and Antje Habel and Werner Paulus and Dirk Troost and \{von Deimling\}, Andreas",

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AU - Sahm, Felix

AU - Capper, David

AU - Jeibmann, Astrid

AU - Habel, Antje

AU - Paulus, Werner

AU - Troost, Dirk

AU - von Deimling, Andreas

PY - 2012

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N2 - Objective: To analyze infiltration patterns of IDH1 mutant diffuse gliomas into the brain by identification of single tumor cells applying an antibody specific to mutant IDH1 R132H protein. Design: Immunohistochemical analysis. Setting: University hospital. Patients: Whole-brain and hemisphere sections of 4 patients diagnosed with diffuse glioma. Results: Tumor cells were identified in areas that appeared inconspicuous macroscopically and at histological analysis with respect to cellularity, cellular pleomorphism, or mitotic activity in all cases. Conclusion: Detection of single tumor cells throughout the brain demonstrates diffuse glioma to represent systemic brain disease

AB - Objective: To analyze infiltration patterns of IDH1 mutant diffuse gliomas into the brain by identification of single tumor cells applying an antibody specific to mutant IDH1 R132H protein. Design: Immunohistochemical analysis. Setting: University hospital. Patients: Whole-brain and hemisphere sections of 4 patients diagnosed with diffuse glioma. Results: Tumor cells were identified in areas that appeared inconspicuous macroscopically and at histological analysis with respect to cellularity, cellular pleomorphism, or mitotic activity in all cases. Conclusion: Detection of single tumor cells throughout the brain demonstrates diffuse glioma to represent systemic brain disease

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DO - 10.1001/archneurol.2011.2910

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ER -

Addressing Diffuse Glioma as a Systemic Brain Disease With Single-Cell Analysis

Abstract

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