Achieving High-Precision Attenuation Coefficient Measurement in Optical Coherence Tomography

Linda B. Neubrand; Xavier Attendu; Ton G. van Leeuwen

doi:10.1002/jbio.202400395

Achieving High-Precision Attenuation Coefficient Measurement in Optical Coherence Tomography

Linda B. Neubrand^*
, Xavier Attendu
, Ton G. van Leeuwen

^*Corresponding author for this work

University of Amsterdam
Amsterdam UMC
Polytechnique Montreal

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

In this study, we aim to validate the analytical Cramer-Rao lower bound (CRLB) equation for determining attenuation coefficients using a 1310 nm Optical Coherence Tomography (OCT) system. Our experimental results successfully confirm the validity of the equation, achieving unprecedented precision with a standard deviation below 0.01 mm−1 for intralipid samples. Furthermore, we introduce a systematic framework for attaining high precision in OCT attenuation measurements.

Original language	English
Article number	e202400395
Journal	Journal of biophotonics
Volume	18
Issue number	3
Early online date	2025
DOIs	https://doi.org/10.1002/jbio.202400395
Publication status	Published - 1 Mar 2025

Keywords

Cramér–Rao lower bound
Fisher matrix
attenuation coefficient
curve-fitting
depth-resolved estimation
optical coherence tomography
precision

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title = "Achieving High-Precision Attenuation Coefficient Measurement in Optical Coherence Tomography",

abstract = "In this study, we aim to validate the analytical Cramer-Rao lower bound (CRLB) equation for determining attenuation coefficients using a 1310 nm Optical Coherence Tomography (OCT) system. Our experimental results successfully confirm the validity of the equation, achieving unprecedented precision with a standard deviation below 0.01 mm−1 for intralipid samples. Furthermore, we introduce a systematic framework for attaining high precision in OCT attenuation measurements.",

keywords = "Cram{\'e}r–Rao lower bound, Fisher matrix, attenuation coefficient, curve-fitting, depth-resolved estimation, optical coherence tomography, precision",

author = "Neubrand, \{Linda B.\} and Xavier Attendu and \{van Leeuwen\}, \{Ton G.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Journal of Biophotonics published by Wiley-VCH GmbH.",

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AU - Neubrand, Linda B.

AU - Attendu, Xavier

AU - van Leeuwen, Ton G.

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Y1 - 2025/3/1

N2 - In this study, we aim to validate the analytical Cramer-Rao lower bound (CRLB) equation for determining attenuation coefficients using a 1310 nm Optical Coherence Tomography (OCT) system. Our experimental results successfully confirm the validity of the equation, achieving unprecedented precision with a standard deviation below 0.01 mm−1 for intralipid samples. Furthermore, we introduce a systematic framework for attaining high precision in OCT attenuation measurements.

AB - In this study, we aim to validate the analytical Cramer-Rao lower bound (CRLB) equation for determining attenuation coefficients using a 1310 nm Optical Coherence Tomography (OCT) system. Our experimental results successfully confirm the validity of the equation, achieving unprecedented precision with a standard deviation below 0.01 mm−1 for intralipid samples. Furthermore, we introduce a systematic framework for attaining high precision in OCT attenuation measurements.

KW - Cramér–Rao lower bound

KW - Fisher matrix

KW - attenuation coefficient

KW - curve-fitting

KW - depth-resolved estimation

KW - optical coherence tomography

KW - precision

UR - https://www.scopus.com/pages/publications/86000373211

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DO - 10.1002/jbio.202400395

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JF - Journal of biophotonics

IS - 3

M1 - e202400395

ER -

Achieving High-Precision Attenuation Coefficient Measurement in Optical Coherence Tomography

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Keywords

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