A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era

Stefan M. Pfister; Miguel Reyes-Múgica; John K. C. Chan; Henrik Hasle; Alexander J. Lazar; Sabrina Rossi; Andrea Ferrari; Jason A. Jarzembowski; Kathy Pritchard-Jones; D. Ashley Hill; Thomas S. Jacques; Pieter Wesseling; Dolores H. López Terrada; Andreas von Deimling; Christian P. Kratz; Ian A. Cree; Rita Alaggio

doi:10.1158/2159-8290.CD-21-1094

A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era

Stefan M. Pfister^*
, Miguel Reyes-Múgica
, John K. C. Chan
, Henrik Hasle
, Alexander J. Lazar
, Sabrina Rossi
, Andrea Ferrari
, Jason A. Jarzembowski
, Kathy Pritchard-Jones
, D. Ashley Hill
, Thomas S. Jacques
, Pieter Wesseling
, Dolores H. López Terrada
, Andreas von Deimling
, Christian P. Kratz
, Ian A. Cree
, Rita Alaggio^*

^*Corresponding author for this work

Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
German Cancer Research Center
Heidelberg University
University of Pittsburgh
Queen Elizabeth Hospital Hong Kong
Aarhus University
University of Texas MD Anderson Cancer Center
IRCCS Ospedale pediatrico Bambino Gesù - Roma
IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano
Medical College of Wisconsin
University College London
George Washington University
NIHR Great Ormond Street Biomedical Research Centre, London, UK
Princess Máxima Center for Pediatric Oncology
Amsterdam UMC - University of Amsterdam
Baylor College of Medicine
Hannover Medical School
International Agency for Research on Cancer
Hopp Children’s Cancer Center Heidelberg (KiTZ)
National Center for Tumor Diseases Heidelberg
Heidelberg University Hospital
Aarhus University Hospital
University of Amsterdam
Texas Children's Hospital Houston

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often originating from a single genetic driver event. The specific diagnostic challenges of childhood tumors led to the development of the first World Health Organization (WHO) Classification of Pediatric Tumors. The classification is rooted in a multilayered approach, incorporating morphology, IHC, and molecular characteristics. The volume is organized according to organ sites and provides a single, state-of-the-art compendium of pediatric tumor types. A special emphasis was placed on “blastomas,” which variably recapitulate the morphologic maturation of organs from which they originate.

Original language	English
Pages (from-to)	331-355
Number of pages	25
Journal	Cancer discovery
Volume	12
Issue number	2
DOIs	https://doi.org/10.1158/2159-8290.CD-21-1094
Publication status	Published - 1 Feb 2022

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Pfister, S. M., Reyes-Múgica, M., Chan, J. K. C., Hasle, H., Lazar, A. J., Rossi, S., Ferrari, A., Jarzembowski, J. A., Pritchard-Jones, K., Hill, D. A., Jacques, T. S., Wesseling, P., López Terrada, D. H., von Deimling, A., Kratz, C. P., Cree, I. A., & Alaggio, R. (2022). A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era. Cancer discovery, 12(2), 331-355. https://doi.org/10.1158/2159-8290.CD-21-1094

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abstract = "Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often originating from a single genetic driver event. The specific diagnostic challenges of childhood tumors led to the development of the first World Health Organization (WHO) Classification of Pediatric Tumors. The classification is rooted in a multilayered approach, incorporating morphology, IHC, and molecular characteristics. The volume is organized according to organ sites and provides a single, state-of-the-art compendium of pediatric tumor types. A special emphasis was placed on {\textquotedblleft}blastomas,{\textquotedblright} which variably recapitulate the morphologic maturation of organs from which they originate.",

author = "Pfister, \{Stefan M.\} and Miguel Reyes-M{\'u}gica and Chan, \{John K. C.\} and Henrik Hasle and Lazar, \{Alexander J.\} and Sabrina Rossi and Andrea Ferrari and Jarzembowski, \{Jason A.\} and Kathy Pritchard-Jones and Hill, \{D. Ashley\} and Jacques, \{Thomas S.\} and Pieter Wesseling and \{L{\'o}pez Terrada\}, \{Dolores H.\} and \{von Deimling\}, Andreas and Kratz, \{Christian P.\} and Cree, \{Ian A.\} and Rita Alaggio",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors; Published by the American Association for Cancer Research.",

year = "2022",

month = feb,

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doi = "10.1158/2159-8290.CD-21-1094",

language = "English",

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Pfister, SM, Reyes-Múgica, M, Chan, JKC, Hasle, H, Lazar, AJ, Rossi, S, Ferrari, A, Jarzembowski, JA, Pritchard-Jones, K, Hill, DA, Jacques, TS, Wesseling, P, López Terrada, DH, von Deimling, A, Kratz, CP, Cree, IA & Alaggio, R 2022, 'A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era', Cancer discovery, vol. 12, no. 2, pp. 331-355. https://doi.org/10.1158/2159-8290.CD-21-1094

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AU - Reyes-Múgica, Miguel

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AU - Hasle, Henrik

AU - Lazar, Alexander J.

AU - Rossi, Sabrina

AU - Ferrari, Andrea

AU - Jarzembowski, Jason A.

AU - Pritchard-Jones, Kathy

AU - Hill, D. Ashley

AU - Jacques, Thomas S.

AU - Wesseling, Pieter

AU - López Terrada, Dolores H.

AU - von Deimling, Andreas

AU - Kratz, Christian P.

AU - Cree, Ian A.

AU - Alaggio, Rita

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A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era

Abstract

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