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A structured framework for standardized 3D leg alignment analysis: an international Delphi consensus study

  • Quinten W. T. Veerman*
  • , Gabriëlle J. M. Tuijthof
  • , Nico Verdonschot
  • , Reinoud W. Brouwer
  • , Peter Verdonk
  • , Annemieke van Haver
  • , Hugo C. van der Veen
  • , Peter A. J. Pijpker
  • , Judith olde Heuvel
  • , Roy A. G. Hoogeslag
  • , Ahmet Erdemir
  • , Antoine Perrier
  • , Bastian Sigrist
  • , Bernardo Innocenti
  • , Carl W. Imhauser
  • , Claudio Belvedere
  • , Gwendolyn Vuurberg
  • , Harrie Weinans
  • , Julian Fürmetz
  • , Laura Carman
  • Leendert Blankevoort, Mark Taylor, Mathias Donnez, Matthias J. Feucht, Matthieu Ollivier, Michael T. Hirschmann, Min Jung, Oguzhan Tanoğlu, Philipp Niemeyer, Raghbir Khakha, Roel J. H. Custers, Ronald van Heerwaarden, Ruurd J. A. Kuiper, Sandro F. Fucentese, Steven Claes, Thor F. Besier, Vicente J. León-Muñoz, Wolf Petersen, Wouter van Genechten, the 3D Leg Alignment Consensus Expert Group
*Corresponding author for this work
  • Centre for Orthopaedic Surgery and Sports Medicine OCON
  • University of Twente
  • Radboud University Nijmegen
  • Martini Ziekenhuis
  • University of Antwerp
  • AZ Monica
  • Radboudumc, afd. Medische Oncologie, Nijmegen
  • University of Groningen
  • Cleveland Clinic Foundation
  • Université Grenoble Alpes
  • TwInsight
  • Balgrist University Hospital
  • Université libre de Bruxelles
  • Hospital for Special Surgery - New York
  • IRCCS Istituto Ortopedico Rizzoli - Bologna
  • Utrecht University
  • Trauma Center Murnau
  • Ludwig Maximilian University of Munich
  • The University of Auckland
  • University of Amsterdam
  • Amsterdam UMC
  • Flinders University
  • Haute-Goulaine
  • University of Freiburg
  • Aix-Marseille Université
  • Kantonsspital Baselland
  • University of Basel
  • Yonsei University
  • Izmir Democracy University
  • OCM
  • Guy's and St Thomas' NHS Foundation Trust
  • Centre for Deformity Correction and Joint Preserving Surgery
  • AZ Herentals Hospital
  • Instituto de Cirugía Avanzada de la Rodilla (ICAR)
  • University of Murcia
  • Reina Sofia Hospital
  • Martin Luther Hospital
  • Fudan University

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Purpose: To reach consensus among international experts on a structured framework for standardized 3D leg alignment analysis based on 3D bone models, ensuring consistency and improving clinical applicability. Methods: A Delphi study was performed in four rounds. Rounds 1 and 2 involved a steering and rating group that developed statements based on principles preserving the 3D complexity of anatomical structures, identified through a systematic review. These statements encompassed approaches for deriving joint centres and joint orientations, and defining coordinate systems using 3D bone models. In Rounds 3 and 4, a panel of 35 international experts, including clinicians (54%) and engineers (46%), with participants from Europe (80%), Oceania (9%), Asia (6%), and the Americas (6%), evaluated these statements. Consensus was defined as ≥80% agreement. Results: Rounds 1 and 2 resulted in 31 statements to be included in the survey. Of these, 26 achieved consensus in Round 3, with the five remaining statements refined and reaching consensus in Round 4. Experts agreed on utilising all available relevant surface data to define joint centres, joint orientations, and individual femoral and tibial coordinate systems alongside a combined leg coordinate system, and adopting central 3D axes for femoral version and tibial torsion. Conclusions: This international Delphi consensus study provides a structured framework for a standardized 3D leg alignment analysis based on 3D bone models. This framework aims to enhance clinical applicability for preoperative planning and execution of uni- and multiplanar correction osteotomies around the knee, reduce the methodological variability in 3D leg alignment analysis literature, and improve cross-study comparability. Level of Evidence: Level V.
Original languageEnglish
Pages (from-to)2276-2292
Number of pages17
JournalKnee surgery, sports traumatology, arthroscopy
Volume33
Issue number6
Early online date2025
DOIs
Publication statusPublished - Jun 2025

Keywords

  • alignment parameters
  • consensus
  • coordinate systems
  • joint orientation
  • knee

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