A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study

Catherine Kelly; Caroline Trumpff; Carlos Acosta; Stephanie Assuras; Jack Baker; Sophia Basarrate; Alexander Behnke; Ke Bo; Natalia Bobba-Alves; Frances A. Champagne; Quinn Conklin; Marissa Cross; Philip de Jager; Kris Engelstad; Elissa Epel; Soah G. Franklin; Michio Hirano; Qiuhan Huang; Alex Junker; Robert-Paul Juster; Darshana Kapri; Clemens Kirschbaum; Mangesh Kurade; Vincenzo Lauriola; Shufang Li; Cynthia C. Liu; Grace Liu; Bruce McEwen; Marlon A. McGill; Kathleen McIntyre; Anna S. Monzel; Jeremy Michelson; Aric A. Prather; Eli Puterman; Xiomara Q. Rosales; Peter A. Shapiro; David Shire; George M. Slavich; Richard P. Sloan; Janell L. M. Smith; Marisa Spann; Julie Spicer; Gabriel Sturm; Sophia Tepler; Michel Thiebaut de Schotten; Tor D. Wager; Martin Picard

doi:10.1016/j.tem.2024.08.006

A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study

Catherine Kelly
, Caroline Trumpff
, Carlos Acosta
, Stephanie Assuras
, Jack Baker
, Sophia Basarrate
, Alexander Behnke
, Ke Bo
, Natalia Bobba-Alves
, Frances A. Champagne
, Quinn Conklin
, Marissa Cross
, Philip de Jager
, Kris Engelstad
, Elissa Epel
, Soah G. Franklin
, Michio Hirano
, Qiuhan Huang
, Alex Junker
, Robert-Paul Juster

Darshana Kapri, Clemens Kirschbaum, Mangesh Kurade, Vincenzo Lauriola, Shufang Li, Cynthia C. Liu, Grace Liu, Bruce McEwen, Marlon A. McGill, Kathleen McIntyre, Anna S. Monzel, Jeremy Michelson, Aric A. Prather, Eli Puterman, Xiomara Q. Rosales, Peter A. Shapiro, David Shire, George M. Slavich, Richard P. Sloan, Janell L. M. Smith, Marisa Spann, Julie Spicer, Gabriel Sturm, Sophia Tepler, Michel Thiebaut de Schotten, Tor D. Wager, Martin Picard^*

^*Corresponding author for this work

Columbia University
Ulm University
Faculty of Arts and Sciences
University of Texas at Austin
University of California at San Francisco
University of Montreal
Technische Universität Dresden
Rockefeller University
University of British Columbia
University of California at Los Angeles
Icahn School of Medicine at Mount Sinai
Groupe d'Imagerie Neurofonctionnelle

Research output: Contribution to journal › Review article › Academic › peer-review

18 Downloads (Pure)

Abstract

Health emerges from coordinated psychobiological processes powered by mitochondrial energy transformation. But how do mitochondria regulate the multisystem responses that shape resilience and disease risk across the lifespan? The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was established to address this question and determine how mitochondria influence the interconnected neuroendocrine, immune, metabolic, cardiovascular, cognitive, and emotional systems among individuals spanning the spectrum of mitochondrial energy transformation capacity, including participants with rare mitochondrial DNA (mtDNA) lesions causing mitochondrial diseases (MitoDs). This interdisciplinary effort is expected to generate new insights into the pathophysiology of MitoDs, provide a foundation to develop novel biomarkers of human health, and integrate our fragmented knowledge of bioenergetic, brain–body, and mind–mitochondria processes relevant to medicine and public health.

Original language	English
Pages (from-to)	884-901
Number of pages	18
Journal	TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume	35
Issue number	10
DOIs	https://doi.org/10.1016/j.tem.2024.08.006
Publication status	Published - 1 Oct 2024
Externally published	Yes

Keywords

allostasis
metabolism
mitochondrial disorders
mtDNA
psychobiology
stress

Access to Document

10.1016/j.tem.2024.08.006

A-platform-to-map-the-mindmitochondria-connection-and-the-hallmarks-of-psychobiology.pdfFinal published version, 3.71 MBLicence: CC BY

Cite this

Kelly, C., Trumpff, C., Acosta, C., Assuras, S., Baker, J., Basarrate, S., Behnke, A., Bo, K., Bobba-Alves, N., Champagne, F. A., Conklin, Q., Cross, M., de Jager, P., Engelstad, K., Epel, E., Franklin, S. G., Hirano, M., Huang, Q., Junker, A., ... Picard, M. (2024). A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 35(10), 884-901. https://doi.org/10.1016/j.tem.2024.08.006

@article{b0b2081f688d42a8b152d1d26411ab98,

title = "A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study",

abstract = "Health emerges from coordinated psychobiological processes powered by mitochondrial energy transformation. But how do mitochondria regulate the multisystem responses that shape resilience and disease risk across the lifespan? The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was established to address this question and determine how mitochondria influence the interconnected neuroendocrine, immune, metabolic, cardiovascular, cognitive, and emotional systems among individuals spanning the spectrum of mitochondrial energy transformation capacity, including participants with rare mitochondrial DNA (mtDNA) lesions causing mitochondrial diseases (MitoDs). This interdisciplinary effort is expected to generate new insights into the pathophysiology of MitoDs, provide a foundation to develop novel biomarkers of human health, and integrate our fragmented knowledge of bioenergetic, brain–body, and mind–mitochondria processes relevant to medicine and public health.",

keywords = "allostasis, metabolism, mitochondrial disorders, mtDNA, psychobiology, stress",

author = "Catherine Kelly and Caroline Trumpff and Carlos Acosta and Stephanie Assuras and Jack Baker and Sophia Basarrate and Alexander Behnke and Ke Bo and Natalia Bobba-Alves and Champagne, \{Frances A.\} and Quinn Conklin and Marissa Cross and \{de Jager\}, Philip and Kris Engelstad and Elissa Epel and Franklin, \{Soah G.\} and Michio Hirano and Qiuhan Huang and Alex Junker and Robert-Paul Juster and Darshana Kapri and Clemens Kirschbaum and Mangesh Kurade and Vincenzo Lauriola and Shufang Li and Liu, \{Cynthia C.\} and Grace Liu and Bruce McEwen and McGill, \{Marlon A.\} and Kathleen McIntyre and Monzel, \{Anna S.\} and Jeremy Michelson and Prather, \{Aric A.\} and Eli Puterman and Rosales, \{Xiomara Q.\} and Shapiro, \{Peter A.\} and David Shire and Slavich, \{George M.\} and Sloan, \{Richard P.\} and Smith, \{Janell L. M.\} and Marisa Spann and Julie Spicer and Gabriel Sturm and Sophia Tepler and \{de Schotten\}, \{Michel Thiebaut\} and Wager, \{Tor D.\} and Martin Picard",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = oct,

day = "1",

doi = "10.1016/j.tem.2024.08.006",

language = "English",

volume = "35",

pages = "884--901",

journal = "TRENDS IN ENDOCRINOLOGY AND METABOLISM",

issn = "1043-2760",

publisher = "Elsevier Inc.",

number = "10",

}

Kelly, C, Trumpff, C, Acosta, C, Assuras, S, Baker, J, Basarrate, S, Behnke, A, Bo, K, Bobba-Alves, N, Champagne, FA, Conklin, Q, Cross, M, de Jager, P, Engelstad, K, Epel, E, Franklin, SG, Hirano, M, Huang, Q, Junker, A, Juster, R-P, Kapri, D, Kirschbaum, C, Kurade, M, Lauriola, V, Li, S, Liu, CC, Liu, G, McEwen, B, McGill, MA, McIntyre, K, Monzel, AS, Michelson, J, Prather, AA, Puterman, E, Rosales, XQ, Shapiro, PA, Shire, D, Slavich, GM, Sloan, RP, Smith, JLM, Spann, M, Spicer, J, Sturm, G, Tepler, S, de Schotten, MT, Wager, TD & Picard, M 2024, 'A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study', TRENDS IN ENDOCRINOLOGY AND METABOLISM, vol. 35, no. 10, pp. 884-901. https://doi.org/10.1016/j.tem.2024.08.006

TY - JOUR

T1 - A platform to map the mind–mitochondria connection and the hallmarks of psychobiology

T2 - the MiSBIE study

AU - Kelly, Catherine

AU - Trumpff, Caroline

AU - Acosta, Carlos

AU - Assuras, Stephanie

AU - Baker, Jack

AU - Basarrate, Sophia

AU - Behnke, Alexander

AU - Bo, Ke

AU - Bobba-Alves, Natalia

AU - Champagne, Frances A.

AU - Conklin, Quinn

AU - Cross, Marissa

AU - de Jager, Philip

AU - Engelstad, Kris

AU - Epel, Elissa

AU - Franklin, Soah G.

AU - Hirano, Michio

AU - Huang, Qiuhan

AU - Junker, Alex

AU - Juster, Robert-Paul

AU - Kapri, Darshana

AU - Kirschbaum, Clemens

AU - Kurade, Mangesh

AU - Lauriola, Vincenzo

AU - Li, Shufang

AU - Liu, Cynthia C.

AU - Liu, Grace

AU - McEwen, Bruce

AU - McGill, Marlon A.

AU - McIntyre, Kathleen

AU - Monzel, Anna S.

AU - Michelson, Jeremy

AU - Prather, Aric A.

AU - Puterman, Eli

AU - Rosales, Xiomara Q.

AU - Shapiro, Peter A.

AU - Shire, David

AU - Slavich, George M.

AU - Sloan, Richard P.

AU - Smith, Janell L. M.

AU - Spann, Marisa

AU - Spicer, Julie

AU - Sturm, Gabriel

AU - Tepler, Sophia

AU - de Schotten, Michel Thiebaut

AU - Wager, Tor D.

AU - Picard, Martin

PY - 2024/10/1

Y1 - 2024/10/1

N2 - Health emerges from coordinated psychobiological processes powered by mitochondrial energy transformation. But how do mitochondria regulate the multisystem responses that shape resilience and disease risk across the lifespan? The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was established to address this question and determine how mitochondria influence the interconnected neuroendocrine, immune, metabolic, cardiovascular, cognitive, and emotional systems among individuals spanning the spectrum of mitochondrial energy transformation capacity, including participants with rare mitochondrial DNA (mtDNA) lesions causing mitochondrial diseases (MitoDs). This interdisciplinary effort is expected to generate new insights into the pathophysiology of MitoDs, provide a foundation to develop novel biomarkers of human health, and integrate our fragmented knowledge of bioenergetic, brain–body, and mind–mitochondria processes relevant to medicine and public health.

AB - Health emerges from coordinated psychobiological processes powered by mitochondrial energy transformation. But how do mitochondria regulate the multisystem responses that shape resilience and disease risk across the lifespan? The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was established to address this question and determine how mitochondria influence the interconnected neuroendocrine, immune, metabolic, cardiovascular, cognitive, and emotional systems among individuals spanning the spectrum of mitochondrial energy transformation capacity, including participants with rare mitochondrial DNA (mtDNA) lesions causing mitochondrial diseases (MitoDs). This interdisciplinary effort is expected to generate new insights into the pathophysiology of MitoDs, provide a foundation to develop novel biomarkers of human health, and integrate our fragmented knowledge of bioenergetic, brain–body, and mind–mitochondria processes relevant to medicine and public health.

KW - allostasis

KW - metabolism

KW - mitochondrial disorders

KW - mtDNA

KW - psychobiology

KW - stress

UR - https://www.scopus.com/pages/publications/85206113223

U2 - 10.1016/j.tem.2024.08.006

DO - 10.1016/j.tem.2024.08.006

M3 - Review article

C2 - 39389809

SN - 1043-2760

VL - 35

SP - 884

EP - 901

JO - TRENDS IN ENDOCRINOLOGY AND METABOLISM

JF - TRENDS IN ENDOCRINOLOGY AND METABOLISM

IS - 10

ER -

A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this