A new murine model to study the pathogenesis of tuberculous meningitis

Gijs Th. J. van Well; Catharina W. Wieland; Sandrine Florquin; John J. Roord; Tom van der Poll; A. Marceline van Furth

doi:10.1086/511273

A new murine model to study the pathogenesis of tuberculous meningitis

Gijs Th. J. van Well
, Catharina W. Wieland
, Sandrine Florquin
, John J. Roord
, Tom van der Poll
, A. Marceline van Furth

VU Medisch Centrum
Academic Medical Centre, University of Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Tuberculous meningitis (TM) is a severe complication of tuberculosis that mainly occurs during childhood. No murine models are available to study this disease. The purpose of the present study was to develop a murine model to investigate the pathogenesis of TM. Mice were intracerebrally injected with Mycobacterium tuberculosis. Bacilli could be cultured from brain homogenates, and, on histopathological examination, all mice were found to have meningeal cellular infiltration. We found elevated levels of chemoattractants for mononuclear phagocytes and neutrophilic granulocytes. This is the first murine model for TM that can be used for research on the host response to TM, in particular the innate immune response

Original language	English
Pages (from-to)	694-697
Number of pages	4
Journal	Journal of infectious diseases
Volume	195
Issue number	5
DOIs	https://doi.org/10.1086/511273
Publication status	Published - 1 Mar 2007

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title = "A new murine model to study the pathogenesis of tuberculous meningitis",

abstract = "Tuberculous meningitis (TM) is a severe complication of tuberculosis that mainly occurs during childhood. No murine models are available to study this disease. The purpose of the present study was to develop a murine model to investigate the pathogenesis of TM. Mice were intracerebrally injected with Mycobacterium tuberculosis. Bacilli could be cultured from brain homogenates, and, on histopathological examination, all mice were found to have meningeal cellular infiltration. We found elevated levels of chemoattractants for mononuclear phagocytes and neutrophilic granulocytes. This is the first murine model for TM that can be used for research on the host response to TM, in particular the innate immune response",

author = "\{van Well\}, \{Gijs Th. J.\} and Wieland, \{Catharina W.\} and Sandrine Florquin and Roord, \{John J.\} and \{van der Poll\}, Tom and \{van Furth\}, \{A. Marceline\}",

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doi = "10.1086/511273",

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T1 - A new murine model to study the pathogenesis of tuberculous meningitis

AU - van Well, Gijs Th. J.

AU - Wieland, Catharina W.

AU - Florquin, Sandrine

AU - Roord, John J.

AU - van der Poll, Tom

AU - van Furth, A. Marceline

PY - 2007/3/1

Y1 - 2007/3/1

N2 - Tuberculous meningitis (TM) is a severe complication of tuberculosis that mainly occurs during childhood. No murine models are available to study this disease. The purpose of the present study was to develop a murine model to investigate the pathogenesis of TM. Mice were intracerebrally injected with Mycobacterium tuberculosis. Bacilli could be cultured from brain homogenates, and, on histopathological examination, all mice were found to have meningeal cellular infiltration. We found elevated levels of chemoattractants for mononuclear phagocytes and neutrophilic granulocytes. This is the first murine model for TM that can be used for research on the host response to TM, in particular the innate immune response

AB - Tuberculous meningitis (TM) is a severe complication of tuberculosis that mainly occurs during childhood. No murine models are available to study this disease. The purpose of the present study was to develop a murine model to investigate the pathogenesis of TM. Mice were intracerebrally injected with Mycobacterium tuberculosis. Bacilli could be cultured from brain homogenates, and, on histopathological examination, all mice were found to have meningeal cellular infiltration. We found elevated levels of chemoattractants for mononuclear phagocytes and neutrophilic granulocytes. This is the first murine model for TM that can be used for research on the host response to TM, in particular the innate immune response

UR - https://www.scopus.com/pages/publications/33847067894

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DO - 10.1086/511273

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SP - 694

EP - 697

JO - Journal of infectious diseases

JF - Journal of infectious diseases

IS - 5

ER -

A new murine model to study the pathogenesis of tuberculous meningitis

Abstract

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