A human monoclonal antibody cocktail as a novel component of rabies postexposure prophylaxis

John de Kruif; Alexander B. H. Bakker; Wilfred E. Marissen; R. Arjen Kramer; Mark Throsby; Charles E. Rupprecht; Jaap Goudsmit

doi:10.1146/annurev.med.58.061705.145053

A human monoclonal antibody cocktail as a novel component of rabies postexposure prophylaxis

John de Kruif
, Alexander B. H. Bakker
, Wilfred E. Marissen
, R. Arjen Kramer
, Mark Throsby
, Charles E. Rupprecht
, Jaap Goudsmit

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

The currently recommended treatment for individuals exposed to rabies virus is the combined administration of rabies vaccine and rabies immune globulin (RIG). This review sets out the criteria used to guide development of a cocktail of human monoclonal antibodies as a replacement for RIG. Using this process as a model, the general requirements for development of safe and efficacious monoclonal antibody alternatives to currently used polyclonal serum products are discussed

Original language	English
Pages (from-to)	359-368
Journal	Annual review of medicine
Volume	58
DOIs	https://doi.org/10.1146/annurev.med.58.061705.145053
Publication status	Published - 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1146/annurev.med.58.061705.145053

Cite this

@article{638cad232c1849bb9200a0144471c8fe,

title = "A human monoclonal antibody cocktail as a novel component of rabies postexposure prophylaxis",

abstract = "The currently recommended treatment for individuals exposed to rabies virus is the combined administration of rabies vaccine and rabies immune globulin (RIG). This review sets out the criteria used to guide development of a cocktail of human monoclonal antibodies as a replacement for RIG. Using this process as a model, the general requirements for development of safe and efficacious monoclonal antibody alternatives to currently used polyclonal serum products are discussed",

author = "\{de Kruif\}, John and Bakker, \{Alexander B. H.\} and Marissen, \{Wilfred E.\} and Kramer, \{R. Arjen\} and Mark Throsby and Rupprecht, \{Charles E.\} and Jaap Goudsmit",

year = "2007",

doi = "10.1146/annurev.med.58.061705.145053",

language = "English",

volume = "58",

pages = "359--368",

journal = "Annual review of medicine",

issn = "0066-4219",

publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - A human monoclonal antibody cocktail as a novel component of rabies postexposure prophylaxis

AU - de Kruif, John

AU - Bakker, Alexander B. H.

AU - Marissen, Wilfred E.

AU - Kramer, R. Arjen

AU - Throsby, Mark

AU - Rupprecht, Charles E.

AU - Goudsmit, Jaap

PY - 2007

Y1 - 2007

N2 - The currently recommended treatment for individuals exposed to rabies virus is the combined administration of rabies vaccine and rabies immune globulin (RIG). This review sets out the criteria used to guide development of a cocktail of human monoclonal antibodies as a replacement for RIG. Using this process as a model, the general requirements for development of safe and efficacious monoclonal antibody alternatives to currently used polyclonal serum products are discussed

AB - The currently recommended treatment for individuals exposed to rabies virus is the combined administration of rabies vaccine and rabies immune globulin (RIG). This review sets out the criteria used to guide development of a cocktail of human monoclonal antibodies as a replacement for RIG. Using this process as a model, the general requirements for development of safe and efficacious monoclonal antibody alternatives to currently used polyclonal serum products are discussed

U2 - 10.1146/annurev.med.58.061705.145053

DO - 10.1146/annurev.med.58.061705.145053

M3 - Review article

C2 - 16886905

SN - 0066-4219

VL - 58

SP - 359

EP - 368

JO - Annual review of medicine

JF - Annual review of medicine

ER -

A human monoclonal antibody cocktail as a novel component of rabies postexposure prophylaxis

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this