A genome wide association analysis in the GENDER study

M. L. Sampietro; D. Pons; P. de Knijff; P. E. Slagboom; A. Zwinderman; J. W. Jukema

doi:10.1007/BF03086261

A genome wide association analysis in the GENDER study

M. L. Sampietro
, D. Pons
, P. de Knijff
, P. E. Slagboom
, A. Zwinderman
, J. W. Jukema

Research output: Contribution to journal › Editorial › Academic › peer-review

Abstract

Percutaneous coronary intervention (PCI) has become an effective therapy to treat coronary artery diseases. However, one of the major drawbacks of PCI is the occurrence of restenosis in 8 to 40% of all treated patients. The GENetic Determinants of Restenosis (GENDER) project was designed to study the association between genetic polymorphisims and clinical restenosis. The discovery of genetic variants associated to the occurrence of restenosis after PCI may provide a more tailored therapy and may serve as rationale for new antirestenotic therapies. So far, several candidate gene approaches had already been performed in the GENDER samples but a Genome Wide Association Scan (GWAS) was still lacking. Here, we present preliminary results from the GWAS we are currently carrying out in the GENDER population. (Neth Heart J 2009;17:262-4.)

Original language	English
Pages (from-to)	262-264
Journal	Netherlands heart journal
Volume	17
Issue number	6
DOIs	https://doi.org/10.1007/BF03086261
Publication status	Published - 2009

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title = "A genome wide association analysis in the GENDER study",

abstract = "Percutaneous coronary intervention (PCI) has become an effective therapy to treat coronary artery diseases. However, one of the major drawbacks of PCI is the occurrence of restenosis in 8 to 40\% of all treated patients. The GENetic Determinants of Restenosis (GENDER) project was designed to study the association between genetic polymorphisims and clinical restenosis. The discovery of genetic variants associated to the occurrence of restenosis after PCI may provide a more tailored therapy and may serve as rationale for new antirestenotic therapies. So far, several candidate gene approaches had already been performed in the GENDER samples but a Genome Wide Association Scan (GWAS) was still lacking. Here, we present preliminary results from the GWAS we are currently carrying out in the GENDER population. (Neth Heart J 2009;17:262-4.)",

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T1 - A genome wide association analysis in the GENDER study

AU - Sampietro, M. L.

AU - Pons, D.

AU - de Knijff, P.

AU - Slagboom, P. E.

AU - Zwinderman, A.

AU - Jukema, J. W.

PY - 2009

Y1 - 2009

N2 - Percutaneous coronary intervention (PCI) has become an effective therapy to treat coronary artery diseases. However, one of the major drawbacks of PCI is the occurrence of restenosis in 8 to 40% of all treated patients. The GENetic Determinants of Restenosis (GENDER) project was designed to study the association between genetic polymorphisims and clinical restenosis. The discovery of genetic variants associated to the occurrence of restenosis after PCI may provide a more tailored therapy and may serve as rationale for new antirestenotic therapies. So far, several candidate gene approaches had already been performed in the GENDER samples but a Genome Wide Association Scan (GWAS) was still lacking. Here, we present preliminary results from the GWAS we are currently carrying out in the GENDER population. (Neth Heart J 2009;17:262-4.)

AB - Percutaneous coronary intervention (PCI) has become an effective therapy to treat coronary artery diseases. However, one of the major drawbacks of PCI is the occurrence of restenosis in 8 to 40% of all treated patients. The GENetic Determinants of Restenosis (GENDER) project was designed to study the association between genetic polymorphisims and clinical restenosis. The discovery of genetic variants associated to the occurrence of restenosis after PCI may provide a more tailored therapy and may serve as rationale for new antirestenotic therapies. So far, several candidate gene approaches had already been performed in the GENDER samples but a Genome Wide Association Scan (GWAS) was still lacking. Here, we present preliminary results from the GWAS we are currently carrying out in the GENDER population. (Neth Heart J 2009;17:262-4.)

U2 - 10.1007/BF03086261

DO - 10.1007/BF03086261

M3 - Editorial

C2 - 19789690

SN - 1568-5888

VL - 17

SP - 262

EP - 264

JO - Netherlands heart journal

JF - Netherlands heart journal

IS - 6

ER -

A genome wide association analysis in the GENDER study

Abstract

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