Abstract
The F4/80 monoclonal antibody has been used widely as a marker for mouse macrophages. The antigen (Ag) recognized by the antibody has been characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family, although the function of the molecule has remained elusive. A recent study provides evidence for a role of the F4/80 molecule in the induction of immunological tolerance. This study appears to provide clear evidence for a role of the F4/80 molecule in the immune system, however, what does it really tell us about the activities of the F4/80 molecule?
| Original language | English |
|---|---|
| Pages (from-to) | 506-9 |
| Number of pages | 4 |
| Journal | Trends in immunology |
| Volume | 26 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2005 |
Keywords
- Animals
- Antibodies, Monoclonal/immunology
- Antibody Specificity
- Antigens, Differentiation/physiology
- Glycoproteins/genetics
- Immune Tolerance/immunology
- Macrophages/immunology
- Mice
- Models, Immunological
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