A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

Marte Molenaars; Georges E. Janssens; Evan G. Williams; Aldo Jongejan; Jiayi Lan; Sylvie Rabot; Fatima Joly; Perry D. Moerland; Bauke V. Schomakers; Marco Lezzerini; Yasmine J. Liu; Mark A. McCormick; Brian K. Kennedy; Michel van Weeghel; Antoine H. C. van Kampen; Ruedi Aebersold; Alyson W. MacInnes; Riekelt H. Houtkooper

doi:10.1016/j.cmet.2020.01.011

A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

Marte Molenaars
, Georges E. Janssens
, Evan G. Williams
, Aldo Jongejan
, Jiayi Lan
, Sylvie Rabot
, Fatima Joly
, Perry D. Moerland
, Bauke V. Schomakers
, Marco Lezzerini
, Yasmine J. Liu
, Mark A. McCormick
, Brian K. Kennedy
, Michel van Weeghel
, Antoine H. C. van Kampen
, Ruedi Aebersold
, Alyson W. MacInnes
, Riekelt H. Houtkooper

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Molenaars, Janssens, and colleagues report on a natural balance between cytosolic and mitochondrial ribosomal proteins, driven by an active link between two longevity pathways. They demonstrate that the inhibition of mitochondrial translation regulates cytosolic translation via the transcription factor Atf4/atf-5, a phenomenon conserved in worms, human cells, and in vivo in mice.

Original language	English
Pages (from-to)	549-563.e7
Journal	Cell metabolism
Volume	31
Issue number	3
DOIs	https://doi.org/10.1016/j.cmet.2020.01.011
Publication status	Published - 3 Mar 2020

Keywords

ATF4
aging
cytosolic translation
doxycycline
longevity
mitochondrial translation
polysome
ribosomes
translational balance
translational efficiency

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10.1016/j.cmet.2020.01.011

A Conserved Mito-Cytosolic Translational Balance Links Two Longevity PathwaysAccepted author manuscript, 6.19 MBLicence: CC BY-NC-ND

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Molenaars, M., Janssens, G. E., Williams, E. G., Jongejan, A., Lan, J., Rabot, S., Joly, F., Moerland, P. D., Schomakers, B. V., Lezzerini, M., Liu, Y. J., McCormick, M. A., Kennedy, B. K., van Weeghel, M., van Kampen, A. H. C., Aebersold, R., MacInnes, A. W., & Houtkooper, R. H. (2020). A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways. Cell metabolism, 31(3), 549-563.e7. https://doi.org/10.1016/j.cmet.2020.01.011

@article{73e8621d82ac40b19980d66ca2daa6f2,

title = "A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways",

abstract = "Molenaars, Janssens, and colleagues report on a natural balance between cytosolic and mitochondrial ribosomal proteins, driven by an active link between two longevity pathways. They demonstrate that the inhibition of mitochondrial translation regulates cytosolic translation via the transcription factor Atf4/atf-5, a phenomenon conserved in worms, human cells, and in vivo in mice.",

keywords = "ATF4, aging, cytosolic translation, doxycycline, longevity, mitochondrial translation, polysome, ribosomes, translational balance, translational efficiency",

author = "Marte Molenaars and Janssens, \{Georges E.\} and Williams, \{Evan G.\} and Aldo Jongejan and Jiayi Lan and Sylvie Rabot and Fatima Joly and Moerland, \{Perry D.\} and Schomakers, \{Bauke V.\} and Marco Lezzerini and Liu, \{Yasmine J.\} and McCormick, \{Mark A.\} and Kennedy, \{Brian K.\} and \{van Weeghel\}, Michel and \{van Kampen\}, \{Antoine H. C.\} and Ruedi Aebersold and MacInnes, \{Alyson W.\} and Houtkooper, \{Riekelt H.\}",

year = "2020",

month = mar,

day = "3",

doi = "10.1016/j.cmet.2020.01.011",

language = "English",

volume = "31",

pages = "549--563.e7",

journal = "Cell metabolism",

issn = "1550-4131",

publisher = "Cell Press",

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Molenaars, M , Janssens, GE, Williams, EG, Jongejan, A, Lan, J, Rabot, S, Joly, F, Moerland, PD, Schomakers, BV, Lezzerini, M, Liu, YJ, McCormick, MA, Kennedy, BK, van Weeghel, M , van Kampen, AHC, Aebersold, R, MacInnes, AW & Houtkooper, RH 2020, 'A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways', Cell metabolism, vol. 31, no. 3, pp. 549-563.e7. https://doi.org/10.1016/j.cmet.2020.01.011

TY - JOUR

T1 - A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

AU - Molenaars, Marte

AU - Janssens, Georges E.

AU - Williams, Evan G.

AU - Jongejan, Aldo

AU - Lan, Jiayi

AU - Rabot, Sylvie

AU - Joly, Fatima

AU - Moerland, Perry D.

AU - Schomakers, Bauke V.

AU - Lezzerini, Marco

AU - Liu, Yasmine J.

AU - McCormick, Mark A.

AU - Kennedy, Brian K.

AU - van Weeghel, Michel

AU - van Kampen, Antoine H. C.

AU - Aebersold, Ruedi

AU - MacInnes, Alyson W.

AU - Houtkooper, Riekelt H.

PY - 2020/3/3

Y1 - 2020/3/3

N2 - Molenaars, Janssens, and colleagues report on a natural balance between cytosolic and mitochondrial ribosomal proteins, driven by an active link between two longevity pathways. They demonstrate that the inhibition of mitochondrial translation regulates cytosolic translation via the transcription factor Atf4/atf-5, a phenomenon conserved in worms, human cells, and in vivo in mice.

AB - Molenaars, Janssens, and colleagues report on a natural balance between cytosolic and mitochondrial ribosomal proteins, driven by an active link between two longevity pathways. They demonstrate that the inhibition of mitochondrial translation regulates cytosolic translation via the transcription factor Atf4/atf-5, a phenomenon conserved in worms, human cells, and in vivo in mice.

KW - ATF4

KW - aging

KW - cytosolic translation

KW - doxycycline

KW - longevity

KW - mitochondrial translation

KW - polysome

KW - ribosomes

KW - translational balance

KW - translational efficiency

UR - https://www.scopus.com/pages/publications/85080073181

U2 - 10.1016/j.cmet.2020.01.011

DO - 10.1016/j.cmet.2020.01.011

M3 - Article

C2 - 32084377

SN - 1550-4131

VL - 31

SP - 549-563.e7

JO - Cell metabolism

JF - Cell metabolism

IS - 3

ER -

A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

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Keywords

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