A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Eleonora Aronica; Devin K. Binder; Meinrad Drexel; Chrysanthy Ikonomidou; Shilpa D. Kadam; Guenther Sperk; Christian Steinhäuser

doi:10.1002/epi4.12638

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Eleonora Aronica^*
, Devin K. Binder
, Meinrad Drexel
, Chrysanthy Ikonomidou
, Shilpa D. Kadam
, Guenther Sperk^*
, Christian Steinhäuser

^*Corresponding author for this work

Epilepsy Institutes of the Netherlands Foundation
University of California at Riverside
Innsbruck Medical University
University of Wisconsin-Madison
Hugo Moser Research Institute at Kennedy Krieger
Johns Hopkins University
University of Bonn

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs. This article addresses neuropathological changes associated with seizures and epilepsy in rodent models of epilepsy. We discuss CDEs for histopathological parameters for neurodegeneration, changes in astrocyte morphology and function, mechanisms of inflammation, and changes in the blood-brain barrier and myelin/oligodendrocytes resulting from recurrent seizures in rats and mice. We provide detailed CDE tables and case report forms (CRFs), and with this companion manuscript, we discuss the rationale and methodological aspects of individual neuropathological examinations. The CDEs, CRFs, and companion paper are available to all researchers, and their use will benefit the harmonization and comparability of translational preclinical epilepsy research. The ultimate hope is to facilitate the development of rational therapy concepts for treating epilepsies, seizures, and comorbidities and the development of biomarkers assessing the pathological state of the disease.

Original language	English
Journal	Epilepsia Open
Early online date	2022
DOIs	https://doi.org/10.1002/epi4.12638
Publication status	E-pub ahead of print - 2022

Keywords

common data elements
epilepsy
inflammation model
neuropathology
preclinical
rodent

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Aronica, E., Binder, D. K., Drexel, M., Ikonomidou, C., Kadam, S. D., Sperk, G., & Steinhäuser, C. (2022). A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force. Epilepsia Open. Advance online publication. https://doi.org/10.1002/epi4.12638

@article{6ee14e5659924a75a920f7593b49f297,

title = "A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force",

abstract = "The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs. This article addresses neuropathological changes associated with seizures and epilepsy in rodent models of epilepsy. We discuss CDEs for histopathological parameters for neurodegeneration, changes in astrocyte morphology and function, mechanisms of inflammation, and changes in the blood-brain barrier and myelin/oligodendrocytes resulting from recurrent seizures in rats and mice. We provide detailed CDE tables and case report forms (CRFs), and with this companion manuscript, we discuss the rationale and methodological aspects of individual neuropathological examinations. The CDEs, CRFs, and companion paper are available to all researchers, and their use will benefit the harmonization and comparability of translational preclinical epilepsy research. The ultimate hope is to facilitate the development of rational therapy concepts for treating epilepsies, seizures, and comorbidities and the development of biomarkers assessing the pathological state of the disease.",

keywords = "common data elements, epilepsy, inflammation model, neuropathology, preclinical, rodent",

author = "Eleonora Aronica and Binder, \{Devin K.\} and Meinrad Drexel and Chrysanthy Ikonomidou and Kadam, \{Shilpa D.\} and Guenther Sperk and Christian Steinh{\"a}user",

note = "Funding Information: The authors wish to acknowledge the AES and ILAE for their financial support of the TASK3 initiative of the TASK3 group of the ILAE/AES Joint Translational Task Force and Professor Aristea Galanopoulou for initiating this project and for continuous advice and help, as well as Dr. Seonaid Anderson for her assistance of converting the CRFs into the CDEcharts. The authors also acknowledge research support by the Austrian Science Funds (GS and MD, projects P 26680 and P 31777), the National Institutes of Health and Department of Defense, USA (DB), National Institute of Child Health and Human Development, R01HD090884 (SDK), EpiEpiNet H2020, and Widespread‐2020‐5 (EA), Ministry for Science and Research, Germany (projects 16GW0182 CONNEXIN, 01DN20001 CONNEX) and the European Union (H2020‐MSCA‐ITN, grant 722053 EU‐GliaPhD) to CS. Publisher Copyright: {\textcopyright} 2022 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.",

year = "2022",

doi = "10.1002/epi4.12638",

language = "English",

journal = "Epilepsia Open",

issn = "2470-9239",

publisher = "Wiley-Blackwell Publishing Ltd",

}

Aronica, E, Binder, DK, Drexel, M, Ikonomidou, C, Kadam, SD, Sperk, G & Steinhäuser, C 2022, 'A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force', Epilepsia Open. https://doi.org/10.1002/epi4.12638

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force. / Aronica, Eleonora; Binder, Devin K.; Drexel, Meinrad et al.
In: Epilepsia Open, 2022.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

AU - Aronica, Eleonora

AU - Binder, Devin K.

AU - Drexel, Meinrad

AU - Ikonomidou, Chrysanthy

AU - Kadam, Shilpa D.

AU - Sperk, Guenther

AU - Steinhäuser, Christian

N1 - Funding Information: The authors wish to acknowledge the AES and ILAE for their financial support of the TASK3 initiative of the TASK3 group of the ILAE/AES Joint Translational Task Force and Professor Aristea Galanopoulou for initiating this project and for continuous advice and help, as well as Dr. Seonaid Anderson for her assistance of converting the CRFs into the CDEcharts. The authors also acknowledge research support by the Austrian Science Funds (GS and MD, projects P 26680 and P 31777), the National Institutes of Health and Department of Defense, USA (DB), National Institute of Child Health and Human Development, R01HD090884 (SDK), EpiEpiNet H2020, and Widespread‐2020‐5 (EA), Ministry for Science and Research, Germany (projects 16GW0182 CONNEXIN, 01DN20001 CONNEX) and the European Union (H2020‐MSCA‐ITN, grant 722053 EU‐GliaPhD) to CS. Publisher Copyright: © 2022 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.

PY - 2022

Y1 - 2022

N2 - The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs. This article addresses neuropathological changes associated with seizures and epilepsy in rodent models of epilepsy. We discuss CDEs for histopathological parameters for neurodegeneration, changes in astrocyte morphology and function, mechanisms of inflammation, and changes in the blood-brain barrier and myelin/oligodendrocytes resulting from recurrent seizures in rats and mice. We provide detailed CDE tables and case report forms (CRFs), and with this companion manuscript, we discuss the rationale and methodological aspects of individual neuropathological examinations. The CDEs, CRFs, and companion paper are available to all researchers, and their use will benefit the harmonization and comparability of translational preclinical epilepsy research. The ultimate hope is to facilitate the development of rational therapy concepts for treating epilepsies, seizures, and comorbidities and the development of biomarkers assessing the pathological state of the disease.

AB - The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs. This article addresses neuropathological changes associated with seizures and epilepsy in rodent models of epilepsy. We discuss CDEs for histopathological parameters for neurodegeneration, changes in astrocyte morphology and function, mechanisms of inflammation, and changes in the blood-brain barrier and myelin/oligodendrocytes resulting from recurrent seizures in rats and mice. We provide detailed CDE tables and case report forms (CRFs), and with this companion manuscript, we discuss the rationale and methodological aspects of individual neuropathological examinations. The CDEs, CRFs, and companion paper are available to all researchers, and their use will benefit the harmonization and comparability of translational preclinical epilepsy research. The ultimate hope is to facilitate the development of rational therapy concepts for treating epilepsies, seizures, and comorbidities and the development of biomarkers assessing the pathological state of the disease.

KW - common data elements

KW - epilepsy

KW - inflammation model

KW - neuropathology

KW - preclinical

KW - rodent

UR - https://www.scopus.com/pages/publications/85138523558

U2 - 10.1002/epi4.12638

DO - 10.1002/epi4.12638

M3 - Article

C2 - 35938285

SN - 2470-9239

JO - Epilepsia Open

JF - Epilepsia Open

ER -

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

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