A 6-year follow-up of a large European cohort of children with attention-deficit/hyperactivity disorder-combined subtype: outcomes in late adolescence and young adulthood: outcomes in late adolescence and young adulthood

Marloes van Lieshout; Marjolein Luman; Jos W. R. Twisk; Hanneke van Ewijk; Annabeth P. Groenman; Andrieke J. A. M. Thissen; Stephen V. Faraone; Dirk J. Heslenfeld; Catharina A. Hartman; Pieter J. Hoekstra; Barbara Franke; Jan K. Buitelaar; Nanda N. J. Rommelse; Jaap Oosterlaan

doi:10.1007/s00787-016-0820-y

A 6-year follow-up of a large European cohort of children with attention-deficit/hyperactivity disorder-combined subtype: outcomes in late adolescence and young adulthood: outcomes in late adolescence and young adulthood

Marloes van Lieshout
, Marjolein Luman
, Jos W. R. Twisk
, Hanneke van Ewijk
, Annabeth P. Groenman
, Andrieke J. A. M. Thissen
, Stephen V. Faraone
, Dirk J. Heslenfeld
, Catharina A. Hartman
, Pieter J. Hoekstra
, Barbara Franke
, Jan K. Buitelaar
, Nanda N. J. Rommelse
, Jaap Oosterlaan

Vrije Universiteit Amsterdam
Radboud University Medical Center
Karakter Child and Adolescent Psychiatry University Center
SUNY Upstate Medical University
University Medical Center Groningen

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

There are very few studies on the long-term outcome of children and adolescents with ADHD-combined type in Europe. The objective of the present study is to assess the 6-year outcome (including pharmacological treatment) of a large cohort of participants with ADHD-combined type (N = 347, mean age 11.4 years) in late adolescence and early adulthood. At study entry and follow-up (mean age 17.4 years), participants were comprehensively assessed on ADHD and comorbid disorders by structured psychiatric interviews and multi-informant questionnaires. Overall functioning was assessed by the Children's Global Assessment Scale. The retention rate was 75.6 %. The majority of participants (86.5 %) persisted in a DSM-5 ADHD diagnosis, 8.4 % had a subthreshold diagnosis, and 5.1 % remitted from the disorder at follow-up. Comorbidities decreased strongly; oppositional defiant disorder: 58 > 31 %, conduct disorder: 19 > 7 %. At follow-up, mood- and anxiety disorders were virtually non-existent following strict criteria (1-3 %). Percentage of children having had pharmacological treatment at any time increased from 79 to 91 %. On the Children's Global Assessment Scale, 48.5 % of participants were still functionally impaired at follow-up. Parental ADHD, higher ADHD symptom severity at baseline and higher parent-reported impairment at baseline positively predicted current ADHD symptom severity (R (2) = 20.9 %). Younger baseline age, higher ADHD symptom severity at baseline and higher parent-reported impairment at baseline were positively associated with poorer overall functioning (R (2) = 17.8 %). Pharmacological treatment had no (beneficial) impact on either ADHD symptom severity or overall functioning. Results confirm that ADHD is largely persistent into late adolescence with severity and family history for the disorder as important risk factors

Original language	English
Pages (from-to)	1007-1017
Number of pages	11
Journal	European child & adolescent psychiatry
Volume	25
Issue number	9
DOIs	https://doi.org/10.1007/s00787-016-0820-y
Publication status	Published - 1 Sept 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ADHD
Follow-up
Overall functioning
Persistence
Prediction
Symptom severity
Treatment

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10.1007/s00787-016-0820-y

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van Lieshout, M., Luman, M., Twisk, J. W. R., van Ewijk, H., Groenman, A. P., Thissen, A. J. A. M., Faraone, S. V., Heslenfeld, D. J., Hartman, C. A., Hoekstra, P. J., Franke, B., Buitelaar, J. K., Rommelse, N. N. J., & Oosterlaan, J. (2016). A 6-year follow-up of a large European cohort of children with attention-deficit/hyperactivity disorder-combined subtype: outcomes in late adolescence and young adulthood: outcomes in late adolescence and young adulthood. European child & adolescent psychiatry, 25(9), 1007-1017. https://doi.org/10.1007/s00787-016-0820-y

van Lieshout, Marloes ; Luman, Marjolein ; Twisk, Jos W. R. et al. / A 6-year follow-up of a large European cohort of children with attention-deficit/hyperactivity disorder-combined subtype: outcomes in late adolescence and young adulthood : outcomes in late adolescence and young adulthood. In: European child & adolescent psychiatry. 2016 ; Vol. 25, No. 9. pp. 1007-1017.

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title = "A 6-year follow-up of a large European cohort of children with attention-deficit/hyperactivity disorder-combined subtype: outcomes in late adolescence and young adulthood: outcomes in late adolescence and young adulthood",

abstract = "There are very few studies on the long-term outcome of children and adolescents with ADHD-combined type in Europe. The objective of the present study is to assess the 6-year outcome (including pharmacological treatment) of a large cohort of participants with ADHD-combined type (N = 347, mean age 11.4 years) in late adolescence and early adulthood. At study entry and follow-up (mean age 17.4 years), participants were comprehensively assessed on ADHD and comorbid disorders by structured psychiatric interviews and multi-informant questionnaires. Overall functioning was assessed by the Children's Global Assessment Scale. The retention rate was 75.6 \%. The majority of participants (86.5 \%) persisted in a DSM-5 ADHD diagnosis, 8.4 \% had a subthreshold diagnosis, and 5.1 \% remitted from the disorder at follow-up. Comorbidities decreased strongly; oppositional defiant disorder: 58 > 31 \%, conduct disorder: 19 > 7 \%. At follow-up, mood- and anxiety disorders were virtually non-existent following strict criteria (1-3 \%). Percentage of children having had pharmacological treatment at any time increased from 79 to 91 \%. On the Children's Global Assessment Scale, 48.5 \% of participants were still functionally impaired at follow-up. Parental ADHD, higher ADHD symptom severity at baseline and higher parent-reported impairment at baseline positively predicted current ADHD symptom severity (R (2) = 20.9 \%). Younger baseline age, higher ADHD symptom severity at baseline and higher parent-reported impairment at baseline were positively associated with poorer overall functioning (R (2) = 17.8 \%). Pharmacological treatment had no (beneficial) impact on either ADHD symptom severity or overall functioning. Results confirm that ADHD is largely persistent into late adolescence with severity and family history for the disorder as important risk factors",

keywords = "ADHD, Follow-up, Overall functioning, Persistence, Prediction, Symptom severity, Treatment",

author = "\{van Lieshout\}, Marloes and Marjolein Luman and Twisk, \{Jos W. R.\} and \{van Ewijk\}, Hanneke and Groenman, \{Annabeth P.\} and Thissen, \{Andrieke J. A. M.\} and Faraone, \{Stephen V.\} and Heslenfeld, \{Dirk J.\} and Hartman, \{Catharina A.\} and Hoekstra, \{Pieter J.\} and Barbara Franke and Buitelaar, \{Jan K.\} and Rommelse, \{Nanda N. J.\} and Jaap Oosterlaan",

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van Lieshout, M, Luman, M, Twisk, JWR, van Ewijk, H, Groenman, AP, Thissen, AJAM, Faraone, SV, Heslenfeld, DJ, Hartman, CA, Hoekstra, PJ, Franke, B, Buitelaar, JK, Rommelse, NNJ & Oosterlaan, J 2016, 'A 6-year follow-up of a large European cohort of children with attention-deficit/hyperactivity disorder-combined subtype: outcomes in late adolescence and young adulthood: outcomes in late adolescence and young adulthood', European child & adolescent psychiatry, vol. 25, no. 9, pp. 1007-1017. https://doi.org/10.1007/s00787-016-0820-y

A 6-year follow-up of a large European cohort of children with attention-deficit/hyperactivity disorder-combined subtype: outcomes in late adolescence and young adulthood: outcomes in late adolescence and young adulthood. / van Lieshout, Marloes; Luman, Marjolein; Twisk, Jos W. R. et al.
In: European child & adolescent psychiatry, Vol. 25, No. 9, 01.09.2016, p. 1007-1017.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - van Lieshout, Marloes

AU - Luman, Marjolein

AU - Twisk, Jos W. R.

AU - van Ewijk, Hanneke

AU - Groenman, Annabeth P.

AU - Thissen, Andrieke J. A. M.

AU - Faraone, Stephen V.

AU - Heslenfeld, Dirk J.

AU - Hartman, Catharina A.

AU - Hoekstra, Pieter J.

AU - Franke, Barbara

AU - Buitelaar, Jan K.

AU - Rommelse, Nanda N. J.

AU - Oosterlaan, Jaap

PY - 2016/9/1

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N2 - There are very few studies on the long-term outcome of children and adolescents with ADHD-combined type in Europe. The objective of the present study is to assess the 6-year outcome (including pharmacological treatment) of a large cohort of participants with ADHD-combined type (N = 347, mean age 11.4 years) in late adolescence and early adulthood. At study entry and follow-up (mean age 17.4 years), participants were comprehensively assessed on ADHD and comorbid disorders by structured psychiatric interviews and multi-informant questionnaires. Overall functioning was assessed by the Children's Global Assessment Scale. The retention rate was 75.6 %. The majority of participants (86.5 %) persisted in a DSM-5 ADHD diagnosis, 8.4 % had a subthreshold diagnosis, and 5.1 % remitted from the disorder at follow-up. Comorbidities decreased strongly; oppositional defiant disorder: 58 > 31 %, conduct disorder: 19 > 7 %. At follow-up, mood- and anxiety disorders were virtually non-existent following strict criteria (1-3 %). Percentage of children having had pharmacological treatment at any time increased from 79 to 91 %. On the Children's Global Assessment Scale, 48.5 % of participants were still functionally impaired at follow-up. Parental ADHD, higher ADHD symptom severity at baseline and higher parent-reported impairment at baseline positively predicted current ADHD symptom severity (R (2) = 20.9 %). Younger baseline age, higher ADHD symptom severity at baseline and higher parent-reported impairment at baseline were positively associated with poorer overall functioning (R (2) = 17.8 %). Pharmacological treatment had no (beneficial) impact on either ADHD symptom severity or overall functioning. Results confirm that ADHD is largely persistent into late adolescence with severity and family history for the disorder as important risk factors

AB - There are very few studies on the long-term outcome of children and adolescents with ADHD-combined type in Europe. The objective of the present study is to assess the 6-year outcome (including pharmacological treatment) of a large cohort of participants with ADHD-combined type (N = 347, mean age 11.4 years) in late adolescence and early adulthood. At study entry and follow-up (mean age 17.4 years), participants were comprehensively assessed on ADHD and comorbid disorders by structured psychiatric interviews and multi-informant questionnaires. Overall functioning was assessed by the Children's Global Assessment Scale. The retention rate was 75.6 %. The majority of participants (86.5 %) persisted in a DSM-5 ADHD diagnosis, 8.4 % had a subthreshold diagnosis, and 5.1 % remitted from the disorder at follow-up. Comorbidities decreased strongly; oppositional defiant disorder: 58 > 31 %, conduct disorder: 19 > 7 %. At follow-up, mood- and anxiety disorders were virtually non-existent following strict criteria (1-3 %). Percentage of children having had pharmacological treatment at any time increased from 79 to 91 %. On the Children's Global Assessment Scale, 48.5 % of participants were still functionally impaired at follow-up. Parental ADHD, higher ADHD symptom severity at baseline and higher parent-reported impairment at baseline positively predicted current ADHD symptom severity (R (2) = 20.9 %). Younger baseline age, higher ADHD symptom severity at baseline and higher parent-reported impairment at baseline were positively associated with poorer overall functioning (R (2) = 17.8 %). Pharmacological treatment had no (beneficial) impact on either ADHD symptom severity or overall functioning. Results confirm that ADHD is largely persistent into late adolescence with severity and family history for the disorder as important risk factors

KW - ADHD

KW - Follow-up

KW - Overall functioning

KW - Persistence

KW - Prediction

KW - Symptom severity

KW - Treatment

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ER -

van Lieshout M, Luman M, Twisk JWR, van Ewijk H, Groenman AP, Thissen AJAM et al. A 6-year follow-up of a large European cohort of children with attention-deficit/hyperactivity disorder-combined subtype: outcomes in late adolescence and young adulthood: outcomes in late adolescence and young adulthood. European child & adolescent psychiatry. 2016 Sept 1;25(9):1007-1017. doi: 10.1007/s00787-016-0820-y

A 6-year follow-up of a large European cohort of children with attention-deficit/hyperactivity disorder-combined subtype: outcomes in late adolescence and young adulthood: outcomes in late adolescence and young adulthood

Abstract

UN SDGs

Keywords

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