[18F]NaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva: From Molecular Mechanisms to Clinical Applications in Bone Disorders

Jolien Zwama; Neeltje M. Rosenberg; Vincent A. Verheij; Pieter G. H. M. Raijmakers; Maqsood Yaqub; Esmée Botman; Ruben D. de Ruiter; Mark R. Garrelfs; Arend Bökenkamp; Dimitra Micha; Lothar A. Schwarte; Bernd P. Teunissen; Adriaan A. Lammertsma; Ronald Boellaard; Elisabeth M. W. Eekhoff

doi:10.3390/biom14101276

[18F]NaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva: From Molecular Mechanisms to Clinical Applications in Bone Disorders

^*Corresponding author for this work

Vrije Universiteit Amsterdam
Amsterdam UMC
Rare Bone Disease Center Amsterdam
Dijklander Ziekenhuis
University of Amsterdam
University of Groningen

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic bone disorder characterized by episodic flare-ups in connective tissue, which are frequently followed by the formation of heterotopic ossification. The absence of available plasma-soluble biomarkers for flare-ups or heterotopic bone formation poses severe challenges to the monitoring of disease activity to measure or predict disease progression. Recently, 18-fluor-sodium fluoride positron emission tomography/computed tomography ([18F]NaF PET/CT) was introduced as a potential marker for ossifying FOP activity. This review discusses the pharmacokinetics of [18F]NaF in relation to the pathophysiology of FOP, and its use as a marker of local bone metabolism in a variety of bone-related disorders. In addition, the review specifically addresses the applicability of [18F]NaF PET/CT imaging in FOP as a monitoring modality.

Original language	English
Article number	1276
Journal	Biomolecules
Volume	14
Issue number	10
DOIs	https://doi.org/10.3390/biom14101276
Publication status	Published - 1 Oct 2024

Keywords

F-sodium fluoride (F-NaF)
fibrodysplasia ossificans progressiva
heterotopic ossification
musculoskeletal development
osteoblasts
positron emission tomography/computed tomography (PET/CT)
rare bone diseases

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18fnaf-petct-as-a-marker-for-fibrodysplasia-ossificans-progressiva.pdfFinal published version, 961 KBLicence: CC BY

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Zwama, J., Rosenberg, N. M., Verheij, V. A., Raijmakers, P. G. H. M., Yaqub, M., Botman, E., de Ruiter, R. D., Garrelfs, M. R., Bökenkamp, A., Micha, D., Schwarte, L. A., Teunissen, B. P., Lammertsma, A. A., Boellaard, R., & Eekhoff, E. M. W. (2024). [18F]NaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva: From Molecular Mechanisms to Clinical Applications in Bone Disorders. Biomolecules, 14(10), Article 1276. https://doi.org/10.3390/biom14101276

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title = "[18F]NaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva: From Molecular Mechanisms to Clinical Applications in Bone Disorders",

abstract = "Fibrodysplasia ossificans progressiva (FOP) is a rare genetic bone disorder characterized by episodic flare-ups in connective tissue, which are frequently followed by the formation of heterotopic ossification. The absence of available plasma-soluble biomarkers for flare-ups or heterotopic bone formation poses severe challenges to the monitoring of disease activity to measure or predict disease progression. Recently, 18-fluor-sodium fluoride positron emission tomography/computed tomography ([18F]NaF PET/CT) was introduced as a potential marker for ossifying FOP activity. This review discusses the pharmacokinetics of [18F]NaF in relation to the pathophysiology of FOP, and its use as a marker of local bone metabolism in a variety of bone-related disorders. In addition, the review specifically addresses the applicability of [18F]NaF PET/CT imaging in FOP as a monitoring modality.",

keywords = "F-sodium fluoride (F-NaF), fibrodysplasia ossificans progressiva, heterotopic ossification, musculoskeletal development, osteoblasts, positron emission tomography/computed tomography (PET/CT), rare bone diseases",

author = "Jolien Zwama and Rosenberg, \{Neeltje M.\} and Verheij, \{Vincent A.\} and Raijmakers, \{Pieter G. H. M.\} and Maqsood Yaqub and Esm{\'e}e Botman and \{de Ruiter\}, \{Ruben D.\} and Garrelfs, \{Mark R.\} and Arend B{\"o}kenkamp and Dimitra Micha and Schwarte, \{Lothar A.\} and Teunissen, \{Bernd P.\} and Lammertsma, \{Adriaan A.\} and Ronald Boellaard and Eekhoff, \{Elisabeth M. W.\}",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = oct,

day = "1",

doi = "10.3390/biom14101276",

language = "English",

volume = "14",

journal = "Biomolecules",

issn = "2218-273X",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "10",

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Zwama, J , Rosenberg, NM , Verheij, VA , Raijmakers, PGHM , Yaqub, M , Botman, E , de Ruiter, RD , Garrelfs, MR , Bökenkamp, A , Micha, D , Schwarte, LA , Teunissen, BP, Lammertsma, AA, Boellaard, R & Eekhoff, EMW 2024, '[18F]NaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva: From Molecular Mechanisms to Clinical Applications in Bone Disorders', Biomolecules, vol. 14, no. 10, 1276. https://doi.org/10.3390/biom14101276

TY - JOUR

T1 - [18F]NaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva

T2 - From Molecular Mechanisms to Clinical Applications in Bone Disorders

AU - Zwama, Jolien

AU - Rosenberg, Neeltje M.

AU - Verheij, Vincent A.

AU - Raijmakers, Pieter G. H. M.

AU - Yaqub, Maqsood

AU - Botman, Esmée

AU - de Ruiter, Ruben D.

AU - Garrelfs, Mark R.

AU - Bökenkamp, Arend

AU - Micha, Dimitra

AU - Schwarte, Lothar A.

AU - Teunissen, Bernd P.

AU - Lammertsma, Adriaan A.

AU - Boellaard, Ronald

AU - Eekhoff, Elisabeth M. W.

PY - 2024/10/1

Y1 - 2024/10/1

N2 - Fibrodysplasia ossificans progressiva (FOP) is a rare genetic bone disorder characterized by episodic flare-ups in connective tissue, which are frequently followed by the formation of heterotopic ossification. The absence of available plasma-soluble biomarkers for flare-ups or heterotopic bone formation poses severe challenges to the monitoring of disease activity to measure or predict disease progression. Recently, 18-fluor-sodium fluoride positron emission tomography/computed tomography ([18F]NaF PET/CT) was introduced as a potential marker for ossifying FOP activity. This review discusses the pharmacokinetics of [18F]NaF in relation to the pathophysiology of FOP, and its use as a marker of local bone metabolism in a variety of bone-related disorders. In addition, the review specifically addresses the applicability of [18F]NaF PET/CT imaging in FOP as a monitoring modality.

AB - Fibrodysplasia ossificans progressiva (FOP) is a rare genetic bone disorder characterized by episodic flare-ups in connective tissue, which are frequently followed by the formation of heterotopic ossification. The absence of available plasma-soluble biomarkers for flare-ups or heterotopic bone formation poses severe challenges to the monitoring of disease activity to measure or predict disease progression. Recently, 18-fluor-sodium fluoride positron emission tomography/computed tomography ([18F]NaF PET/CT) was introduced as a potential marker for ossifying FOP activity. This review discusses the pharmacokinetics of [18F]NaF in relation to the pathophysiology of FOP, and its use as a marker of local bone metabolism in a variety of bone-related disorders. In addition, the review specifically addresses the applicability of [18F]NaF PET/CT imaging in FOP as a monitoring modality.

KW - F-sodium fluoride (F-NaF)

KW - fibrodysplasia ossificans progressiva

KW - heterotopic ossification

KW - musculoskeletal development

KW - osteoblasts

KW - positron emission tomography/computed tomography (PET/CT)

KW - rare bone diseases

UR - https://www.scopus.com/pages/publications/85207679333

U2 - 10.3390/biom14101276

DO - 10.3390/biom14101276

M3 - Review article

C2 - 39456213

SN - 2218-273X

VL - 14

JO - Biomolecules

JF - Biomolecules

IS - 10

M1 - 1276

ER -

[18F]NaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva: From Molecular Mechanisms to Clinical Applications in Bone Disorders

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Keywords

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