TY - JOUR
T1 - Multicenter Retrospective Study of Spiroplasma ixodetis Infantile Cataract in 8 Countries in Europe
AU - van Os, Luc
AU - Cassoux, Nathalie
AU - Cholidis, Symira
AU - Dureau, Pascal
AU - Farassat, Navid
AU - Fierz, Fabienne Catherine
AU - Ghyczy, Ebba
AU - Nitulescu, Elena-Cristina
AU - Stifter, Eva
AU - Tassignon, Marie-José
AU - le Flèche-Matéos, Anne
AU - Spiroplasma Infantile Cataract Group
AU - Lorenz, Birgit
AU - Andrassi-Darida, Monika
AU - Ciubotaru, Andreea
AU - Denier, Margot
AU - Domann, Eugen
AU - Gerth-Kahlert, Christina
AU - Hermansen, Nils Olav
AU - Imirzalioglu, Can
AU - Imkamp, Frank
AU - Jäger, Melanie
AU - Lagrèze, Wolf Alexander
AU - Lomprez, Fabienne
AU - Madkaud, Anne-Claude
AU - Magdowski, Gerd
AU - Martin, Gilles
AU - Matet, Alexandre
AU - Matheeussen, Veerle
AU - Saurenmann, Rotraud
AU - Schultz, Christian
AU - Serr, Annerose
AU - Skogen, Anne Regine
AU - Tan, H. Stevie
AU - van Houdt, Robin
AU - van Hatte, Jarne M.
AU - Zucol, Franziska
N1 - Publisher Copyright:
© 2025, Centers for Disease Control and Prevention (CDC). All rigths reserved.
PY - 2025/6/1
Y1 - 2025/6/1
N2 - Spiroplasma ixodetis has been reported to cause the rare combination of cataract and uveitis in infants. Through a retrospective analysis of available literature and additional unpublished cases, we identified 28 eyes from 18 infants from 8 countries in Europe with cataracts and intraocular inflammation. The cataracts were bilateral in 55.6%, unilateral in 44.4%, and progressive in 46.4% of patients. Granulomatous anterior uveitis was found in all infants. Presence of S. ixodetis was supported by PCR (positive in 89.3% of eyes tested), transmission electron microscopy (positive in 90% of eyes tested), or culture of aspirated lens material (positive in 87.5% of eyes tested). Treatment with macrolide antimicrobial drugs, corticosteroids, and lensectomy appeared to be effective. Two patients had a recurrence of the uveitis after lens extraction and needed prolonged treatment. To increase awareness of S. ixodetis, we suggest its inclusion with the organisms of the TORCH acronym.
AB - Spiroplasma ixodetis has been reported to cause the rare combination of cataract and uveitis in infants. Through a retrospective analysis of available literature and additional unpublished cases, we identified 28 eyes from 18 infants from 8 countries in Europe with cataracts and intraocular inflammation. The cataracts were bilateral in 55.6%, unilateral in 44.4%, and progressive in 46.4% of patients. Granulomatous anterior uveitis was found in all infants. Presence of S. ixodetis was supported by PCR (positive in 89.3% of eyes tested), transmission electron microscopy (positive in 90% of eyes tested), or culture of aspirated lens material (positive in 87.5% of eyes tested). Treatment with macrolide antimicrobial drugs, corticosteroids, and lensectomy appeared to be effective. Two patients had a recurrence of the uveitis after lens extraction and needed prolonged treatment. To increase awareness of S. ixodetis, we suggest its inclusion with the organisms of the TORCH acronym.
UR - https://www.scopus.com/pages/publications/105007125973
U2 - 10.3201/eid3106.240954
DO - 10.3201/eid3106.240954
M3 - Article
C2 - 40439349
SN - 1080-6040
VL - 31
SP - 1081
EP - 1089
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 6
ER -