Projects per year
Project Details
Description
We hypothesize that liraglutide treatment (a GLP-1 analogue), initiated before
cardiac surgery, is effective in lowering the number of patients needing perioperative insulin adjustments and reducing the total amount of insulin needed in the perioperative period when aiming for a moderate glucose target of < 8 mmol l-1.
cardiac surgery, is effective in lowering the number of patients needing perioperative insulin adjustments and reducing the total amount of insulin needed in the perioperative period when aiming for a moderate glucose target of < 8 mmol l-1.
Layman's description
The GLP-1 receptor agonist Liraglutide was studied as an alternative to insulin for perioperative glucose control during cardiac surgery. As this requires less interventions and improves glucose control with fewer measurements and aditional interventions, this could be an improvement to perioperative glycaemic management.
Key findings
Preoperative liraglutide, compared with placebo, reduces insulin
requirements while improving perioperative glycaemic control during cardiac surgery.
requirements while improving perioperative glycaemic control during cardiac surgery.
| Acronym | GLOBE |
|---|---|
| Status | Finished |
| Effective start/end date | 01/01/2017 → 01/01/2020 |
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
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Multicenter Research Consortium for clinical anaesthesiology trials in cardiac surgery
Hulst, B. (Project Leader), Hermanides, J. (Project Leader), Scohy, T. V. (CoPI), Gerritse, B. M. (CoPI), Godfried, M. B. (CoPI), Monteiro de Olivera, N. (CoPI), Niesten, E. D. (CoPI), Rettig, T. (CoPI), Voogd, M. F. (CoPI), Wink, J. (CoPI) & Bouwman, A. R. (CoPI)
01/01/2017 → …
Project: Research
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NEPHRITIC: Nephroprotection through Incretin Therapy during Intensive Care
Hulst, B. (Project Leader), Hermanides, J. (Project Member), Lankadeva, Y. R. (Project Member), Deane, A. M. (Project Member), Plummer, M. P. (Project Member) & Bellomo, R. (Project Member)
Netherlands Organisation for Health Research and Development ZonMw
01/01/2021 → 31/12/2021
Project: Research
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Glucose Control Therapies in the Perioperative Period
Hulst, B. (Internal PhD candidate), Hermanides, J. (PostDoc), de Vries, J. H. (Project Leader), Preckel, B. (Project Leader) & Hollmann, M. (Project Leader)
01/01/2017 → 20/05/2022
Project: Research
Research output
- 5 Article
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Preoperative liraglutide modulates control of fat and glucose metabolism during cardiopulmonary bypass surgery
van Wilpe, R., Hulst, A. H., Thiessen, S. E., Devries, J. H., Preckel, B. & Hermanides, J., 1 Apr 2025, In: Endocr. Connect.. 14, 4, e240427.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile45 Downloads (Pure) -
Continuous Glucose Monitoring and the Effect of Liraglutide in Cardiac Surgery Patients: A Substudy of the Randomized Controlled GLOBE Trial
Oosterom-Eijmael, M. J. P., Hermanides, J., van Raalte, D. H., Kouw, I. W. K., DeVries, J. H. & Hulst, A. H., Sept 2024, In: Journal of cardiothoracic and vascular anesthesia. 38, 9, p. 1965-1971 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile21 Downloads (Pure) -
Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial
Hulst, A. H., Visscher, M. J., Cherpanath, T. G. V., van de Wouw, L., Godfried, M. B., Thiel, B., Gerritse, B. M., Scohy, T. V., Bouwman, R. A., Willemsen, M. G. A., Hollmann, M. W., Devries, J. H., Preckel, B. & Hermanides, J., 2 Mar 2020, In: Journal of clinical medicine. 9, 3, 673.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile37 Downloads (Pure)
Activities
- 1 Invited talk
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Liraglutide for Perioperative Management of Hyperglycemia In Cardiac Surgery
Hulst, B. (Speaker)
5 Sept 2019Activity: Talk or presentation › Invited talk › Academic