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Yuri Milaneschi

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Yuri Milaneschi

DR., Principal Investigator

 https://orcid.org/0000-0002-3697-6617
  • 26096
    Citations
20052026

Research activity per year

Personal profile

Specialisation

Psychiatry, Epidemiology, Depression, Genomics, Metabolomics

Research interests

I studied and trained in clinical psychology and psychotherapy in Italy. Subsequently, I worked in the field of epidemiology of aging in Italy (InCHIANTI Study 2007-2010) and the USA (National Institute of Aging, 2010-2012). Due to the enriching experience in such diverse contexts my research perspective became inherently multidisciplinary. My main research theme is the study, using the tools of epidemiology, of biological pathways that may have a role in the pathophysiology of depression.

At the Department of Psychiatry of Amsterdam UMC, where I am currently assistant professor of psychiatry and epidemiology, I further developed the investigation of the immuno-metabolic biological pathways involved in depression. Furthermore, I embraced the exciting developments of the genomics era, expanding my skills and moving my research questions beyond the study of biomarkers of depression toward its genetic basis. I wrote invited expert reviews on genetic research in depression, the biological mechanisms connecting depression and obesity and, more recently, presenting the concept of “Immuno-Metabolic Depression”

I am currently member of the The Scientific Quality Committee (SQC) of Amsterdam Public Health and co-PI of the new INFLAMED trial testing anti-inflammatory add-on in the treatment of Immuno-Metabolic Depression

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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Collaborations and top research areas from the last five years

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  • Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies

    23andMe Research Team, Feb 2026, In: Molecular psychiatry. 31, 2, p. 611-621 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    9 Downloads (Pure)

  • Determinants of the plasma metabolome: cross-sectional and longitudinal associations over 6 years in the NESDA cohort

    Klose, D., Milaneschi, Y., Han, L. K. M., van der Wee, N. J. A., Arnold, M., Brydges, C. R., Mahmoudian Dehkordi, S., Kastenmueller, G., Kaddurah-Daouk, R. & Penninx, B. W. J. H., 1 Jan 2026, In: medRxiv. p. 2026.01.14.26344096

    Research output: Contribution to journal › Article › Academic

  • Functional polygenic risk score of glucocorticoid-dependent regulatory element activity and its relation to clinical and stress-related phenotypes

    Linsen, F., Habets, P. C., Milaneschi, Y., Penner-Goeke, S., Mishuris, B., Czamara, D., Penninx, B. W. J. H., Binder, E. B., Meijer, O. C. & Vinkers, C. H., 1 Feb 2026, In: Psychoneuroendocrinology. 184, 107703.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    20 Downloads (Pure)

  • Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

    Veterans Affairs Million Veteran Program, FinnGen & 23andMe Research Team, Feb 2026, In: Nature genetics. 58, 2, p. 275-288 14 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    9 Downloads (Pure)

  • Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants

    Noordam, R., Wang, W., Nagarajan, P., Wang, H., Brown, M. R., Bentley, A. R., Hui, Q., Kraja, A. T., Morrison, J. L., O'Connel, J. R., Lee, S., Schwander, K., Bartz, T. M., de las Fuentes, L., Feitosa, M. F., Guo, X., Hanfei, X., Harris, S. E., Huang, Z. & Kals, M. & 124 others, Lefevre, C., Mangino, M., Milaneschi, Y., van der Most, P. J., Pacheco, N. L., Palmer, N. D., Rao, V., Rauramaa, R., Sun, Q., Tabara, Y., Vojinovic, D., Wang, Y., Weiss, S., Yang, Q., Zhao, W., Zhu, W., Ansari, M. A. Y., Aschard, H., Anugu, P., Assimes, T. L., Attia, J., Baker, L. D., Ballantyne, C., Bazzano, L., Boerwinkle, E., Cade, B., Chen, H.-H., Chen, W., Ida Chen, Y.-D., Chen, Z., Cho, K., de Anda-Duran, I., Dimitrov, L., Do, A., Edwards, T., Faquih, T., Hingorani, A., Fisher-Hoch, S. P., Gaziano, J. M., Gharib, S. A., Giri, A., Ghanbari, M., Grabe, H. J. R., Graff, M., Charles Gu, C., He, J., Heikkinen, S., Hixson, J., Ho, Y.-L., Hood, M. M., Houghton, S. C., Karvonen-Gutierrez, C. A., Kawaguchi, T., Kilpeläinen, T. O., Komulainen, P., Lin, H. J., Linchangco, G. V., Luik, A. I., Ma, J., Meigs, J. B., McCormick, J. B., Menni, C., Nolte, I. M., Norris, J. M., Petty, L. E., Polikowsky, H. G., Raffield, L. M., Rich, S. S., Riha, R. L., Russ, T. C., Ruiz-Narvaez, E. A., Sitlani, C. M., Smith, J. A., Snieder, H., Sofer, T., Shen, B., Tang, J., Taylor, K. D., Teder-Laving, M., Triatin, R., Tsai, M. Y., Völzke, H., Westerman, K. E., Xia, R., Yao, J., Young, K. L., Zhang, R., Zonderman, A. B., Zhu, X., Below, J. E., Cox, S. R., Evans, M., Fornage, M., Fox, E. R., Franceschini, N., Harlow, S. D., Holliday, E., Ikram, M. A., Kelly, T., Lakka, T. A., Lawlor, D. A., Li, C., Liu, C.-T., Mägi, R., Manning, A. K., Matsuda, F., Morrison, A. C., Nauck, M., North, K. E., Penninx, B. W. J., Province, M. A., Psaty, B. M., Rotter, J. I., Spector, T. D., Wagenknecht, L. E., van Dijk, K. W., Wilson, P. W. F., Peyser, P. A., de Vries, P. S., Gauderman, W. J., Sun, Y. V., Chen, H., Rao, D. C. & Redline, S., 1 Jan 2026, In: Atherosclerosis. 412, 120603.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    23 Downloads (Pure)
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