Projects per year
Personal profile
Research interests
My research aims at understanding why an overloaded heart ultimately fails. Our leading thought is that the transition towards failure is governed by regulatory mechanisms that cause an accumulation of maladaptive changes. Our current focus is on genetic mechanisms and mechanisms involving RNA regulatory molecuales like microRNAs, lncRNAs and RNA splicing as key regulators of the adapative and maladaptive changes in the overloaded heart.
Specialisation
Cardiology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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New small molecules for LMNA disease: New small molecules for LMNA disease
Pinto, Y. (Principal investigator)
28/01/2025 → 01/02/2026
Project: Research
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Phlox Therapeutics: Geld via spinoff phlox
Pinto, Y. (Principal investigator)
01/12/2024 → 31/12/2025
Project: Research
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NHS Dekker Tijsen (Stiggelbout)): Dekker Senior Scientist 2022 - Prime-editing to cure genetic cardiomyopathies - dr. W. Stiggelbout-programma
Pinto, Y. (Principal investigator) & Tijsen, A. (Project Leader)
01/01/2023 → 31/12/2027
Project: Research
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NHS Dekker Tijsen: Dekker Senior Scientist 2022 - Prime-editing to cure genetic cardiomyopathies
Pinto, Y. (Principal investigator) & Tijsen, A. (Project Leader)
01/01/2023 → 31/12/2026
Project: Research
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TKI call 2022 - TRACER: RNA therapies to treat cardiomyopathies caused by mutations in RBM20
Pinto, Y. (Principal investigator) & Tijsen, A. (Project Member)
01/11/2022 → 01/11/2025
Project: Research
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Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases
Pinto, Y. M., Elliott, P. M., Arbustini, E., Adler, Y., Anastasakis, A., Böhm, M., Duboc, D., Gimeno, J., de Groote, P., Imazio, M., Heymans, S., Klingel, K., Komajda, M., Limongelli, G., Linhart, A., Mogensen, J., Moon, J., Pieper, P. G., Seferovic, P. M. & Schueler, S. & 3 others, , 2016, In: European heart journal. 37, 23, p. 1850-1858Research output: Contribution to journal › Article › Academic › peer-review
861 Citations (Scopus) -
Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3'-End Formation in the Failing Human Heart
Creemers, E. E., Bawazeer, A., Ugalde, A. P., van Deutekom, H. W. M., van der Made, I., de Groot, N. E., Adriaens, M. E., Cook, S. A., Bezzina, C. R., Hubner, N., van der Velden, J., Elkon, R., Agami, R. & Pinto, Y. M., 5 Feb 2016, In: Circulation research. 118, 3, p. 433-438Research output: Contribution to journal › Article › Academic › peer-review
36 Citations (Scopus) -
RBM20 Regulates Circular RNA Production From the Titin Gene
Khan, M. A. F., Reckman, Y. J., Aufiero, S., van den Hoogenhof, M. M. G., van der Made, I., Beqqali, A., Koolbergen, D. R., Rasmussen, T. B., van der Velden, J., Creemers, E. E. & Pinto, Y. M., 14 Oct 2016, In: Circulation research. 119, 9, p. 996-1003Research output: Contribution to journal › Article › Academic › peer-review
236 Citations (Scopus) -
Variants in the 3 untranslated region of the KCNQ1-encoded K(v)7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner
Amin, A. S., Giudicessi, J. R., Tijsen, A. J., Spanjaart, A. M., Reckman, Y. J., Klemens, C. A., Tanck, M. W., Kapplinger, J. D., Hofman, N., Sinner, M. F., Müller, M., Wijnen, W. J., Tan, H. L., Bezzina, C. R., Creemers, E. E., Wilde, A. A. M., Ackerman, M. J. & Pinto, Y. M., 2012, In: European heart journal. 33, 6, p. 714-723Research output: Contribution to journal › Article › Academic › peer-review
123 Citations (Scopus) -
Risk Factors for Malignant Ventricular Arrhythmias in Lamin A/C Mutation Carriers A European Cohort Study
van Rijsingen, I. A. W., Arbustini, E., Elliott, P. M., Mogensen, J., Hermans-van Ast, J. F., van der Kooi, A. J., van Tintelen, J. P., van den Berg, M. P., Pilotto, A., Pasotti, M., Jenkins, S., Rowland, C., Aslam, U., Wilde, A. A. M., Perrot, A., Pankuweit, S., Zwinderman, A. H., Charron, P. & Pinto, Y. M., 2012, In: Journal of the American College of Cardiology. 59, 5, p. 493-500Research output: Contribution to journal › Article › Academic › peer-review
450 Citations (Scopus)
Datasets
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Additional file 6 of circRNAprofiler: an R-based computational framework for the downstream analysis of circular RNAs
Aufiero, S. (Creator), Reckman, Y. J. (Contributor), Tijsen, A. J. (Creator), Pinto, Y. M. (Creator) & Creemers, E. E. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12218798.v1, https://springernature.figshare.com/articles/Additional_file_6_of_circRNAprofiler_an_R-based_computational_framework_for_the_downstream_analysis_of_circular_RNAs/12218798/1
Dataset
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Additional file 3 of circRNAprofiler: an R-based computational framework for the downstream analysis of circular RNAs
Aufiero, S. (Creator), Reckman, Y. J. (Contributor), Tijsen, A. J. (Creator), Pinto, Y. M. (Creator) & Creemers, E. E. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12218783, https://springernature.figshare.com/articles/Additional_file_3_of_circRNAprofiler_an_R-based_computational_framework_for_the_downstream_analysis_of_circular_RNAs/12218783
Dataset
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Additional file 3 of circRNAprofiler: an R-based computational framework for the downstream analysis of circular RNAs
Aufiero, S. (Creator), Reckman, Y. J. (Contributor), Tijsen, A. J. (Creator), Pinto, Y. M. (Creator) & Creemers, E. E. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12218783.v1, https://springernature.figshare.com/articles/Additional_file_3_of_circRNAprofiler_an_R-based_computational_framework_for_the_downstream_analysis_of_circular_RNAs/12218783/1
Dataset
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Additional file 2 of circRNAprofiler: an R-based computational framework for the downstream analysis of circular RNAs
Aufiero, S. (Creator), Reckman, Y. J. (Contributor), Tijsen, A. J. (Creator), Pinto, Y. M. (Creator) & Creemers, E. E. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12218780.v1, https://springernature.figshare.com/articles/Additional_file_2_of_circRNAprofiler_an_R-based_computational_framework_for_the_downstream_analysis_of_circular_RNAs/12218780/1
Dataset
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Additional file 5 of circRNAprofiler: an R-based computational framework for the downstream analysis of circular RNAs
Aufiero, S. (Creator), Reckman, Y. J. (Contributor), Tijsen, A. J. (Creator), Pinto, Y. M. (Creator) & Creemers, E. E. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12218795.v1, https://springernature.figshare.com/articles/Additional_file_5_of_circRNAprofiler_an_R-based_computational_framework_for_the_downstream_analysis_of_circular_RNAs/12218795/1
Dataset